self-assembling behaviour
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Short polypeptides with four pentad repeats, (VPGVG)(4) and (VPAVG)(4), were synthesised by manual fluorenylmethoxycarbonyl/tert-butyl (Fmoc/t-Bu) solid phase peptide synthesis using a convergent approach. In the next step, the peptides were coupled via their N-terminus with activated semi-telechelic poly(ethylene glycol) O-(N-Fmoc-2-aminoethyl)-O'-(2-carboxyethyl)undeca(ethylene glycol) (Fmoc-PEG-COOH) to yield monodisperse Fmoc-PEG-peptide diblock copolymer. Both the presence of the terminal hydrophobic Fmoc group and the hydrophilic PEG chain in the copolymers were shown to play a crucial role in their self-associative behaviour, leading to reversible formation of supramolecular thermoresponsive assemblies. The peptides and their PEG derivatives were characterised by HPLC, NMR and MALDI-TOF MS. The associative behaviour of the peptides and their PEG derivatives was studied by dynamic light scattering, MAS NMR and phase contrast microscopy. [image: see text].
- MeSH
- elastin chemie MeSH
- financování organizované MeSH
- konformace proteinů MeSH
- magnetická rezonanční spektroskopie MeSH
- mikroskopie fázově kontrastní MeSH
- molekulární modely MeSH
- oligopeptidy chemická syntéza chemie MeSH
- peptidy chemie MeSH
- polyethylenglykoly chemie MeSH
- radiační rozptyl MeSH
- sekvence aminokyselin MeSH
- spektrometrie hmotnostní - ionizace laserem za účasti matrice MeSH
- termodynamika MeSH
- vysokoúčinná kapalinová chromatografie MeSH
... control 2 -- Vector control at community level 2 -- Selecting the appropriate control measures 2 -- Self-protection ... ... action and design 185 -- Models of traps and screens 186 -- Placement 189 -- Maintenance 195 -- Assembly ... ... 208 -- References 208 -- CONTENTS -- Chapter 3 Triatomine bugs -- Biology 210 -- Life cycle 210 -- Behaviour ... ... mosquito nets 240 -- Smoke generators 240 -- Residual insecticides 241 -- Fleas 243 -- Biology 243 -- Behaviour ... ... 270 -- Tick-borne viral encephalitides 271 -- Other viral diseases 272 -- Control measures 272 -- Self-protection ...
XIII, 412 s. : il. ; 24 cm
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- infekční lékařství
- parazitologie
- cestovní a tropická medicína
- NLK Publikační typ
- publikace WHO
... different dielectrics 84 -- 5.4 Capacitors filled with dielectric material 86 -- 5.5 The electrostatic self-energy ... ... of an isolated conductor 88 -- 5.6 The extra electrostatic energy of an assembly of charges 91 -- 5.7 ... ... The behaviour of ions in narrow pores 197 -- 13.1 Ion channels in biology 197 -- 13.2 The electrostatic ... ... self-energy of an ion in a narrow water-filled pore 198 -- 13.3 Enhanced electrostatic interaction within ...
xii, 286 s.
