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Autor: Racek, J

179 záznamů v BMČ Filtry

Článek

Magnetická rezonance mozku aneb zaměstnavatel nám koupil MR a začínáme vyšetřovat

Praktická radiologie. 2017 ; 22 (4) : 26-32.

Prakt. radiol.
ISSN 1211-5053
Medvik
Zdroj

MeSH
hypofýza diagnostické zobrazování MeSH
kontrastní látky MeSH
lidé MeSH
magnetická rezonanční tomografie * metody přístrojové vybavení MeSH
metodiky postupů * MeSH
mozek * diagnostické zobrazování MeSH
nádory orbity diagnostické zobrazování MeSH
roztroušená skleróza diagnostické zobrazování MeSH
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lidé MeSH
Publikační typ
tabulky MeSH

Článek

Two cases of spuriously elevated cerebrospinal glucose concentration

Annals of clinical biochemistry. 2015 ; 52 (Pt 1) : 161-4. [pub] 20140729

Ann Clin Biochem
ISSN 1758-1001
Medvik
Zdroj

We present two cases of spuriously high cerebrospinal fluid glucose concentration with approximately normal blood glucose concentrations. The cause of these abnormal findings was the use of inappropriate collection tubes during the pre-analytical phase. Whilst no patient harm was identified following this error, significant time and effort were expended by both laboratory and clinical staff to explain the cause of these findings.

MeSH
artefakty * MeSH
B-buněčný lymfom krev diagnóza patologie MeSH
glukosa MeSH
krevní glukóza metabolismus MeSH
lidé středního věku MeSH
lidé MeSH
odběr biologického vzorku normy MeSH
senioři MeSH
vybavení k jednorázovému použití MeSH
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lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
Publikační typ
časopisecké články MeSH
kazuistiky MeSH
práce podpořená grantem MeSH

Článek

Tumor-Stroma-Interaktionen im Harnblasenkarzinom [Tumour-stroma interactions in urothelial cancer]

Der Urologe (Ausg. A). 2015 ; 54 (4) : 516-25.

Urologe (Ausg. A)
ISSN 1433-0563
Medvik
Zdroj

BACKGROUND: The histopathological structure of malignant tumours involves two essential compartments - the tumour parenchyma with the actual transformed cells, and the supportive tumour stroma. The latter consists of specialized mesenchymal cells, such as fibroblasts, macrophages, lymphocytes and vascular cells, as well as of their secreted products, including components of the extracellular matrix, matrix modifying enzymes and numerous regulatory growth factors and cytokines. In consequence, the tumour stroma has the ability to influence virtually all aspects of tumour development and progression, including therapeutic response. AIM: In this article we review the current knowledge of tumor stroma interactions in urothelial carcinoma and present various experimental systems that are currently in use to unravel the biological basis of these heterotypic cell interactions. RESULTS: For urothelial carcinoma, an extensive tumour stroma is quite typical and markers of activated fibroblasts correlate significantly with clinical parameters of advanced disease. Another clinically important variable is provided by the stromal expression of syndecan-1. CONCLUSION: Integration of markers of activated stroma into clinical risk evaluation could aid to better stratification of urothelial bladder carcinoma patients. Elucidation of biological mechanisms underlying tumour-stroma interactions could provide new therapeutical targets.

MeSH
biologické modely MeSH
lidé MeSH
mezibuněčná komunikace MeSH
nádorové mikroprostředí * MeSH
nádorové proteiny metabolismus MeSH
nádory močového měchýře metabolismus patologie MeSH
urotel metabolismus patologie MeSH
zvířata MeSH
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lidé MeSH
zvířata MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
přehledy MeSH

Článek

Signaling molecules for early detection of adverse interactions during mechanical ventilation in animal models

In Vivo. 2011 ; 25 (2) : 209-17.

ISSN 1791-7549
Medvik
Zdroj

AIM: The early identification of adverse interactions during mechanical ventilation, investigated by multiplexed immunoanalysis. MATERIALS AND METHODS: Twenty piglets (average age 7 weeks, weight 23 kg) were intubated and divided into groups: A, spontaneously breathing; B, protectively ventilated; C, ventilated with injurious strategy; D, ventilated with lung disability. At the 1st hour (time-1) and 12th hour (time-2) of the study, brain natriuretic peptide (BNP), intercellular cell adhesion molecules (ICAM-1), vascular cell adhesion molecules (VCAM-1), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (Il-6) were analyzed in the blood. RESULTS: The injurious ventilated group C exhibited an increase in both cell adhesion molecules (p<0.01), TNF-alpha and BNP (p<0.05) at time-1, and at time-2 further increases (p<0.05). In group D, an increase in ICAM-1 and BNP (p<0.05) at time-1, and increases in Il-6 and ICAM-1 (p<0.05) at time-2, with notable decreases in urine output were observed. Overall, the lung damage correlated with TNF-alpha (r=0.904), Il-6 (r=0.740), and ICAM-1 (r=0.756) levels. CONCLUSION: All five monitored molecules quickly and reliably signaled adverse interactions.