AIM: A diabetes-related foot ulcer (DFU) is a major risk factor for lower-extremity amputation (LEA). To help clinicians predict the risk of LEA in people with DFU, the Diabetic Foot Risk Assessment (DIAFORA) system was developed but has never been externally validated. METHODS: In this study, 317 people presenting with a new DFU were included. At baseline, participants were grouped into three groups based on their DIAFORA score: low-risk (<15), medium-risk (15-25), and high-risk (>25). Participants were followed until healing, LEA, death, or at least 3 months. Discriminative accuracy was evaluated using sensitivity, specificity, likelihood ratios (LRs) and the area under the curve (AUC). RESULTS: All 317 participants completed at least 3 months of follow-up for a median duration of 146 days, during which 12.6% underwent minor amputation and 2.5% major amputation. People in the low- and medium-risk categories had major amputation rates of 0.9% and 2.1%, respectively, and negative LR of major LEA of 0.10 and 0.38, respectively, while the people in the high-risk category had an amputation rate of 25.0% and a positive LR of 12.9. The DIAFORA risk groups had a sensitivity of 75.0% and a specificity of 65.7%, with a corresponding AUC of 0.78 (95% CI 0.68-0.87) for the prediction of major LEA. CONCLUSION: The DIAFORA score is a useful tool for risk stratification of people presenting with a newly occurred DFU, with the external validation presenting results similar to those presented in the original study. The DIAFORA score may guide clinicians towards more individualized DFU treatment regimens.
- MeSH
- amputace * statistika a číselné údaje MeSH
- diabetická noha * chirurgie epidemiologie MeSH
- dolní končetina chirurgie MeSH
- hodnocení rizik metody MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- prediktivní hodnota testů MeSH
- prospektivní studie MeSH
- rizikové faktory MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- validační studie MeSH
- Geografické názvy
- Dánsko MeSH
- MeSH
- amputace MeSH
- dospělí MeSH
- infekce * chirurgie terapie MeSH
- lidé MeSH
- nekróza chirurgie terapie MeSH
- pokus o sebevraždu MeSH
- popálení elektrickým proudem * chirurgie komplikace MeSH
- poranění ruky chirurgie komplikace MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- dopisy MeSH
- kazuistiky MeSH
A patient who requests an amputation deemed medically unnecessary by professionals is disqualified per se from being regarded as having medical decision-making capacity. This decision is based on the assumption that there is an option to pursue something other than amputation; such an assumption in many cases overflows into therapeutic obstinacy. This is the case for individuals who have ill or damaged body parts and who wish to avoid recurrent and painful medical treatment designed to save the limb, as well as for individuals affected by body integrity dysphoria (BID). BID is a condition that is recognised by the WHO and is included in the International Classification of Diseases, 11th edition. Individuals who are affected develop an intense feeling of overcompleteness of their body configuration, which leads to the development of a strong sense of dysphoria and consequently the desire to amputate in order to remove the source of such discomfort. In the few cases in which amputation has been carried out, the results have proved successful; the individual's quality of life has improved and they have had no new amputation desires. No medical therapy, including medical amputation, is available currently for individuals affected by the condition. This situation leads many with BID to mutilate themselves. Such events create a challenging ethical dilemma for the medical world.The present paper is focused on the capacity of the individual with BID to do other than request amputation and the implications that this carries regarding moral responsibility. It is proposed that the autonomy of the patient cannot be disqualified by default based on the amputation request, despite its oddity, and that any scepticism demonstrated by the physicians is based on a false preconception of ill will or ignorance, which results in a blaming attitude towards the requesting person.
- MeSH
- amputace * psychologie MeSH
- kvalita života * MeSH
- lidé MeSH
- morální závazky MeSH
- představa o vlastním těle psychologie MeSH
- rozhodování * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- amputace MeSH
- antibakteriální látky terapeutické užití MeSH
- bakteriální infekce farmakoterapie MeSH
- dolní končetina chirurgie patologie MeSH
- hojení ran MeSH
- komorbidita MeSH
- komplexní zdravotní péče MeSH
- lidé středního věku MeSH
- lidé MeSH
- myxoidní liposarkom * chirurgie komplikace MeSH
- pahýl po amputaci patologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- amputace MeSH
- hojení ran * MeSH
- komorbidita MeSH
- lidé MeSH
- péče o kůži metody MeSH
- senioři nad 80 let MeSH
- úrazy pádem MeSH
- vředy dolních končetin * komplikace terapie MeSH
- Check Tag
- lidé MeSH
- senioři nad 80 let MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
This study was aimed to compare the variability of inter-joint coordination in the lower-extremities during gait between active individuals with transtibial amputation (TTAs) and healthy individuals (HIs). Fifteen active male TTAs (age: 40.6 ± 16.24 years, height: 1.74 ± 0.09 m, and mass: 71.2 ± 8.87 kg) and HIs (age: 37.25 ± 13.11 years, height: 1.75 ± 0.06 m, and mass: 74 ± 8.75 kg) without gait disabilities voluntarily participated in the study. Participants walked along a level walkway covered with Vicon motion capture system, and their lower-extremity kinematics data were recorded during gait. The spatiotemporal gait parameters, lower-extremity joint range of motion (ROM), and their coordination and variability were calculated and averaged to report a single value for each parameter based on biomechanical symmetry assumption in the lower limbs of HIs. Additionally, these parameters were separately calculated and reported for the intact limb (IL) and the prosthesis limb (PL) in TTAs individuals. Finally, a comparison was made between the averaged values in HIs and those in the IL and PL of TTAs subjects. The results showed that the IL had a significantly lower stride length than that of the PL and averaged value in HIs, and the IL had a significantly lower knee ROM and greater stance-phase duration than that of HIs. Moreover, TTAs showed different coordination patterns in pelvis-to-hip, hip-to-knee, and hip-to-ankle couplings in some parts of the gait cycle. It concludes that the active TTAs with PLs walked with more flexion of the knee and hip, which may indicate a progressive walking strategy and the differences in coordination patterns suggest active TTA individuals used different neuromuscular control strategies to adapt to their amputation. Researchers can extend this work by investigating variations in these parameters across diverse patient populations, including different amputation etiologies and prosthetic designs. Moreover, Clinicians can use the findings to tailor rehabilitation programs for TTAs, emphasizing joint flexibility and coordination.
- MeSH
- amputace * MeSH
- amputovaní MeSH
- biomechanika MeSH
- chůze (způsob) * fyziologie MeSH
- chůze fyziologie MeSH
- dolní končetina MeSH
- dospělí MeSH
- hlezenní kloub patofyziologie MeSH
- kolenní kloub patofyziologie chirurgie MeSH
- kyčelní kloub chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- rozsah kloubních pohybů * MeSH
- tibie chirurgie patofyziologie MeSH
- umělé končetiny * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Jedenkrát za čtyři roky jsou aktualizována mezinárodní doporučení pro léčbu syndromu diabetické nohy. Článek shrnuje nejnovější doporučení v léčbě infekce a lokální léčbě diabetických uicerací.
Every four years the international guidelines for diabetic foot treatment are updated. This article covers actualization in guidelines in treatment of diabetic foot related infections and local wound therapy.
- Klíčová slova
- Sukrózo-oktasulfát, amniová membrána, náplasti z leukocytů,destiček a fibrinu,
- MeSH
- amputace MeSH
- bakteriální infekce farmakoterapie klasifikace MeSH
- časná diagnóza MeSH
- debridement metody MeSH
- diabetická noha * farmakoterapie komplikace mortalita prevence a kontrola MeSH
- hyperbarická oxygenace MeSH
- lidé MeSH
- obvazy klasifikace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Cíl: Ischemická choroba srdeční se v průběhu času mění. Není známo, jak se změnila ischemická choroba dolních končetin. Metodika, soubor: Z dokumentace naší ordinace jsme vybrali nemocné s ischemickou chorobou dolních končetin. Nemocní byli vyšetřeni klinicky, duplexní sonografií a byl změřen krevní tlak nad kotníky a vyjádřen jako index kotník-paže (ABI). Při dalších kontrolách jsme sledovali vývoj klinického stavu. Za zhoršení jsme považovali zhoršení intermitentních klaudikací anebo vznik kritické končetinové ischemie. Naše nálezy jsme porovnali s výsledky prací dřívějších i nynějších. Výsledky: Do souboru jsme zařadili 406 nemocných, ženy tvořily 38,7 %. U všech nemocných byla příčinou ateroskleróza. Průměrný věk činil 69,5 roku (rozmezí 40–90), 75 % mělo hypertenzní nemoc, 33 % diabetes mellitus, 53,5 % kouřilo. Revaskularizace v anamnéze udávalo 14 % nemocných. Intermitentní klaudikace udávalo 63 %. Déle než jeden rok, v průměru 5,6 roku, jsme sledovali 189 nemocných. Měli podobný věk a rizikové faktory jako celý soubor. Ke klinickému zhoršení došlo u 15,9 % pacientů. Klaudikace se zhoršily u 13,2 %, kritická ischemie vznikla u 5,3 % a amputace u 1,06 %. Revaskularizace byly provedeny u 28 % nemocných. Z celého souboru zemřelo 144 pacientů, z toho 43,7 z kardiovaskulárních příčin a 27,1 na nádorová onemocnění. Závěr: Ischemická choroba dolních končetin postihuje stále starší osoby a přibývá žen. Mají vyšší výskyt rizikových faktorů aterosklerózy než nemocní s ischemickou chorobou srdeční. Díky současné péči, jistě ne optimální, je průběh onemocnění mírnější než před 50 lety. U našich pacientů se klaudikace zhoršovaly méně často a klesl počet amputací. Podíl kardiovaskulárních chorob na úmrtí pacientů s ischemickou chorobou dolních končetin se snížil.
Objective: Coronary artery disease changes over time. It is unknown how the peripheral artery disease of the legs has changed. Methods, the group: We used the medical records of our office to select patients with peripheral artery disease of the legs. The patients underwent clinical assessments including duplex sonography, and their blood pressure at the ankle was measured and expressed as ABI index. Further development of the clinical condition was then followed at subsequent visits. Worsening was defined as worsening of intermittent claudication and/or development of critical limb ischemia. We compared our findings to the results of previous as well as current studies. Results: The group comprised 406 patients including 38.7% females. Atherosclerosis was the cause of the disease in all patients. Mean age was 69.5 years (range 40-90); 75% patients had hypertension, 33% had diabetes mellitus, and 53.5% were smokers. History of revascularization was reported by 14% patients. Intermittent claudication was reported by 63% patients. We followed 189 patients for more than 1 year, 5.6 years on average. Their age and risk factors were similar to those of the entire group. Clinical worsening was experienced by 15.9% patients. Claudication worsened in 13.2% patients, critical ischemia occurred in 5.3% and amputation in 1.06%. Revascularization was performed in 28% patients. One hundred forty-four patients of the entire group died; of these, 43.7 died from cardiovascular causes and 27.1 of cancer. Conclusion: Peripheral artery disease of the legs affects persons of higher age compared to previous times and the proportion of women has increased. The patients show a higher rate of risk factors of atherosclerosis compared to those with coronary artery disease. Thanks to the current care, although certainly not optimal, the course of the disease is less severe than 50 years ago. In our patients, claudication worsening was observed less commonly and the rate of amputations decreased. The number of deaths attributable to cardiovascular diseases in patients with peripheral artery disease of the legs has decreased.
- MeSH
- amputace MeSH
- ateroskleróza diagnóza etiologie komplikace MeSH
- chronická kritická ischemie končetin * diagnostické zobrazování diagnóza komplikace prevence a kontrola MeSH
- dospělí MeSH
- intermitentní klaudikace etiologie MeSH
- ischemická choroba srdeční diagnóza komplikace MeSH
- kardiovaskulární nemoci prevence a kontrola MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- klinická studie MeSH
BACKGROUND: Alternative autologous veins can be used as a conduit when adequate great saphenous vein is unavailable. We analyzed the results of our infrainguinal bypasses after adopting upper extremity veins in our practice. METHODS: This is a single-center observational study involving all patients whose infrainguinal bypass involved the use of upper extremity veins between April 2019, when we began using arm veins, and February 2023. RESULTS: During the study period, 49 bypasses were done in 48 patients; mean age 68.1 ± 9.8; men 32 (66.7%); body mass index 28.0 ± 4.8; indications for surgery: chronic limb threatening ischemia 41 (83.7%); acute limb ischemia 3 (6.1%); complications of previous prosthetic 3 (6.1%), or autologous 2 (4.1%) bypass grafts. Vein splicing was used in 43 (87.8%) bypasses with 3-segment grafts being the most common (26; 53.1%). There were 24 (49.0%) femorotibial, 11 (22.4%) femoropopliteal, 9 (18.4%) femoropedal, and 5 (10.2%) extension jump bypass procedures. Eighteen (36.7%) operations were redo surgeries. Twenty-one (42.9%) bypasses were formed using only arm veins. The median follow-up was 12.9 months (4.5-24.2). Two bypasses occluded during the first 30 postoperative days (2/49; 4.1%). Overall 30-day, 1-year, and 2-year primary patency rates were 93.7% ± 3.5%, 84.8% ± 5.9%, and 80.6% ± 6.9%, and secondary patency (SP) rates were 95.8% ± 2.9%, 89.2% ± 5.3%, and 89.2% ± 5.3%. One-segment grafts had better patencies than 2-, 3-, and 4-segment grafts (1-year SP 100% ± 0% vs 87.6% ± 6.0%). Two-year amputation-free survival was 86.8% ± 6.5%; 2-year overall survival was 88.2% ± 6.6%. CONCLUSIONS: Integration of arm vein grafts in infrainguinal bypass practice can be done safely with low incidences of perioperative graft failure. One-segment grafts had better patencies than spliced vein grafts. The achieved early patency and amputation-free survival rates strongly encourage their use. In the absence of a single-segment great saphenous vein, upper extremity vein grafts should be the preferred conduit choice.
- MeSH
- amputace MeSH
- autologní transplantace * MeSH
- časové faktory MeSH
- horní končetina krevní zásobení MeSH
- lidé středního věku MeSH
- lidé MeSH
- okluze cévního štěpu etiologie patofyziologie chirurgie MeSH
- onemocnění periferních arterií * chirurgie patofyziologie diagnostické zobrazování MeSH
- průchodnost cév * MeSH
- reoperace MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- transplantace cév škodlivé účinky metody MeSH
- vena saphena transplantace MeSH
- vény transplantace chirurgie patofyziologie MeSH
- výsledek terapie MeSH
- záchrana končetiny MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- MeSH
- amputace klasifikace MeSH
- chirurgická rána klasifikace MeSH
- chirurgické laloky klasifikace MeSH
- chirurgie operační * klasifikace metody MeSH
- drenáž klasifikace metody přístrojové vybavení MeSH
- injekce klasifikace přístrojové vybavení škodlivé účinky MeSH
- katetrizace močového měchýře ošetřování přístrojové vybavení MeSH
- krvácení při operaci ošetřování MeSH
- lidé MeSH
- punkce klasifikace metody přístrojové vybavení MeSH
- šicí techniky klasifikace MeSH
- transplantace klasifikace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH