• MeSH
• Electrocardiography MeSH
• Ventricular Flutter diagnosis   physiopathology   MeSH
• Tachycardia, Ventricular * etiology   physiopathology   therapy   MeSH
• Middle Aged MeSH
• Humans MeSH
• Critical Care MeSH
• Heart Failure * diagnosis   etiology   physiopathology   MeSH
• Emergency Medical Services MeSH
• Treatment Outcome MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Anticoagulants therapeutic use   MeSH
• Diagnostic Errors MeSH
• Medical Errors MeSH
• Diagnosis, Differential MeSH
• Fibrinolytic Agents therapeutic use   MeSH
• Ventricular Flutter MeSH
• Pulmonary Embolism diagnosis   drug therapy   prevention & control   MeSH
• Thromboembolism diagnosis   drug therapy   prevention & control   MeSH
• Venous Thrombosis diagnosis   drug therapy   prevention & control   MeSH
• Publication type
• Handbook MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• farmakoterapie
• angiologie

Introduction Mutations of RyR2 gene encoding calcium channel of sarcoplazmatic reticulum are the cause of congenital catecholaminergic polymorphic ventricular tachycardia. The aim of this study was to test the hypothesis that RyR2 variants can increase occurrence of malignant arrhythmias in patients with structural heart diseases. Methods The investigated group consisted of 36 patients with structural heart diseases with ICD implanted who suffered arrhythmic storm. In the control group there were 141 patients with coronary artery disease who were hospitalized at our department owing to an acute coronary event and they were alive at least 3 years after the index event. Thus, they could be considered as a group with a low risk of sudden cardiac death. In all of them mutation analysis of RyR2 gene was performed. Results We detected 16 different sequence changes of RyR2 gene in both groups. None of the found nucleotide polymorphisms led to amino acid changes, were located close to splice sites or had any similarity to known splicing enhancer motifs. The occurrence of these variants was not different in both groups. Conclusions The prevalence of RyR2 gene variants was not different in cases versus controls suggesting a limited role of this gene in the arrhythmogenesis in structural heart disease patients.

• MeSH
• Defibrillators, Implantable utilization   MeSH
• Cardiomyopathy, Dilated genetics   complications   MeSH
• Ventricular Fibrillation etiology   genetics   MeSH
• Financing, Organized MeSH
• Ventricular Flutter etiology   genetics   MeSH
• Ventricular Function, Left genetics   MeSH
• Genetic Predisposition to Disease genetics   MeSH
• Genetic Techniques utilization   MeSH
• Myocardial Ischemia genetics   complications   MeSH
• Humans MeSH
• Meta-Analysis as Topic MeSH
• DNA Mutational Analysis MeSH
• Death, Sudden, Cardiac etiology   pathology   prevention & control   MeSH
• Retrospective Studies MeSH
• Risk Factors MeSH
• Ryanodine Receptor Calcium Release Channel genetics   MeSH
• Arrhythmias, Cardiac etiology   genetics   classification   MeSH
• Statistics as Topic MeSH
• Check Tag
• Humans MeSH

• MeSH
• Atrioventricular Block diagnosis   etiology   classification   MeSH
• Bundle-Branch Block MeSH
• Diagnosis, Differential MeSH
• Ventricular Fibrillation diagnosis   etiology   therapy   MeSH
• Atrial Fibrillation diagnosis   etiology   therapy   MeSH
• Ventricular Flutter diagnosis   etiology   MeSH
• Atrial Flutter diagnosis   etiology   therapy   MeSH
• Tachycardia, Ventricular diagnosis   etiology   classification   MeSH
• Humans MeSH
• Arrhythmias, Cardiac MeSH
• Check Tag
• Humans MeSH

Cíl práce: Najít optimální protokol pro vytváření trojrozměrných modelů srdečních dutin a struktur v okolí srdce pomocí trojrozměrné rotační angiografi e srdce (3DRA). Metodika: U 128 pacientů jsme provedli 3DRA s použitím dvou různých pravosíňových protokolů P1 a P2, jednoho levosíňového protokolu a pravostranný protokol s manuálním startem P3 a sledovali úspěšnost dosažení použitelného 3D modelu srdeční dutiny, většinou levé síně. Provedli jsme i analýzu faktorů ovlivňujících úspěšnost 3DRA (BMI, TF, druh rytmu při nástřiku). U 35 pacientů jsme sledovali úspěšnost zobrazení jícnu pomocí perorálně podané kontrastní látky. Výsledky: Protokol P2 (úspěšnost 87,5 %) se ukázal jako úspěšnější než protokol P1 (úspěšnost 52,94 %). Úspěšnost protokolu P3 s manuálním startem (85 %) se nelišila od protokolu P2. Nejvyšší úspěšnost (97,67 %) byla u levostranného protokolu. Úspěšnost zobrazení jícnu byla 94 %. Závěry: 3D rotační angiografi e srdce je spolehlivou metodou k vytváření 3D modelů srdečních dutin, zejména levé síně. Levostranný přístup je robustní metoda s prakticky 100% úspěšností. U pravostranného přístupu se osvědčil protokol 2 s fi xním zpožděním 9 s. Zobrazení jícnu je jednoduché, spolehlivé a bezpečné.

Aim: To defi ne the optimal protocol for three-dimensional (3D) modeling of heart cavities and adjacent structures using 3D rotational angiography (3DRA). Methods: One hundred twenty-eight patients underwent 3DRA using two diff erent right atrial protocols (P1 and P2), one left atrial protocol and a right-sided protocol with a manual start (P3). The eff ectiveness of useful 3D heart cavity model attainment, mostly concerning the left atrium, was evaluated. The analysis of factors infl uencing the eff ectiveness of 3DRA (BMI, HR, type of rhythm during application of the contrast medium) was also performed. In 35 patients, we evaluated the eff ectiveness of esophagus imaging using oral application of the contrast medium. Results: The protocol P2 (87.5% eff ectiveness) seemed to be more eff ective than the protocol P1 (52.94% eff ectiveness). The eff ectiveness of the protocol P3 with a manual start (85%) was not diff erent from that of the protocol P2. The highest eff ectiveness (97.67%) was demonstrated in the left-sided protocol. The esophagus imaging eff ectiveness was 94%. Conclusion: 3D rotational angiography of the heart is a reliable method for 3D modeling of heart cavities, especially the left ventricle. The left-sided approach is a robust method with almost 100% eff ectiveness. As for the right-sided approach, the protocol 2 with a fi xed 9 sec delay seemed to be the most useful. Esophagus imaging is simple, reliable and safe.

• Keywords
• 3D rotační angiografie srdce, Multislice CT srdečních dutin, Komplexní síňové a komorové arytmie, Katetrová ablace arytmií, Integrace obrazů,
• MeSH
• Angiography methods   MeSH
• Financing, Organized MeSH
• Ventricular Flutter radiography   therapy   MeSH
• Atrial Flutter radiography   therapy   MeSH
• Body Mass Index MeSH
• Catheter Ablation methods   utilization   MeSH
• Coronary Angiography methods   MeSH
• Middle Aged MeSH
• Humans MeSH
• Tomography, X-Ray Computed methods   utilization   MeSH
• Image Processing, Computer-Assisted MeSH
• Heart radiography   MeSH
• Arrhythmias, Cardiac radiography   therapy   MeSH
• Imaging, Three-Dimensional MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH

• MeSH
• Bradycardia diagnosis   therapy   MeSH
• Early Diagnosis MeSH
• Diagnosis, Differential MeSH
• Ventricular Fibrillation diagnosis   therapy   MeSH
• Atrial Fibrillation diagnosis   therapy   MeSH
• Ventricular Flutter diagnosis   therapy   MeSH
• Atrial Flutter diagnosis   therapy   MeSH
• Risk Assessment MeSH
• Humans MeSH
• Arrhythmia, Sinus diagnosis   therapy   MeSH
• Arrhythmias, Cardiac diagnosis   etiology   therapy   MeSH
• Heart Block diagnosis   therapy   MeSH
• Long QT Syndrome diagnosis   therapy   MeSH
• Syncope diagnosis   epidemiology   etiology   MeSH
• Tachycardia diagnosis   therapy   MeSH
• Check Tag
• Humans MeSH

Arteriální hypertenze s následnou hypertrofií levé komory srdeční se podílí na vzniku arytmií několika patofyziologickými mechanismy. Hypertonické srdce se vyznačuje m.j zvýšeným napětím stěny levé síně a levé komory, vyšším výskytem fibrózy, ischémie a apoptózy v myokardu, jakož i změněnými elektrofyziologickými vlastnostmi hypertrofických myocytů; dále dochází k aktivaci sympatického nervového systému a systému renin-angiotensin-aldosteron při systolické anebo diastolické dysfunkci. Také další faktory, jako hyperfunkce štítné žlázy nebo porucha elektrolytové rovnováhy, zvyšují riziko komorových a supraventrikulárních arytmií, popřípadě náhlé arytmogenní srdeční smrti. Ke vzniku arytmie může přispět též antihypertenzní nebo antiarytmická farmakoterapie. Tento článek je zaměřen na komorové tachyarytmie, které jsou nejobávanější, a na nejčastěji se vyskytující arytmii – fibrilaci síní – ve vztahu k hypertonickému srdci. Budou probrány patofyziologické mechanismy, prevalence, prognóza, diagnostika a léčba.

• MeSH
• Anti-Arrhythmia Agents administration & dosage   adverse effects   therapeutic use   MeSH
• Adrenergic beta-Antagonists administration & dosage   adverse effects   therapeutic use   MeSH
• Diagnostic Techniques, Cardiovascular utilization   MeSH
• Electric Countershock methods   utilization   MeSH
• Atrial Fibrillation diagnosis   etiology   complications   MeSH
• Ventricular Flutter diagnosis   etiology   complications   MeSH
• Hypertension complications   physiopathology   prevention & control   MeSH
• Hypertrophy, Left Ventricular diagnosis   etiology   complications   MeSH
• Angiotensin-Converting Enzyme Inhibitors administration & dosage   adverse effects   therapeutic use   MeSH
• Myocardial Ischemia diagnosis   physiopathology   MeSH
• Catheter Ablation methods   utilization   MeSH
• Humans MeSH
• Death, Sudden, Cardiac MeSH
• Risk Factors MeSH
• Arrhythmias, Cardiac diagnosis   etiology   therapy   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Anticoagulants therapeutic use   MeSH
• Diagnostic Errors MeSH
• Medical Errors MeSH
• Diagnosis, Differential MeSH
• Fibrinolytic Agents therapeutic use   MeSH
• Ventricular Flutter MeSH
• Pulmonary Embolism diagnosis   drug therapy   prevention & control   MeSH
• Thromboembolism diagnosis   drug therapy   prevention & control   MeSH
• Venous Thrombosis diagnosis   drug therapy   prevention & control   MeSH
• Publication type
• Handbook MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• angiologie
• farmakoterapie

• MeSH
• Coronary Vessel Anomalies diagnosis   complications   MeSH
• Arrhythmogenic Right Ventricular Dysplasia diagnosis   MeSH
• Brugada Syndrome diagnosis   therapy   MeSH
• Ventricular Fibrillation therapy   MeSH
• Ventricular Flutter therapy   MeSH
• Cardiomyopathy, Hypertrophic diagnosis   MeSH
• Tachycardia, Ventricular diagnosis   complications   MeSH
• Humans MeSH
• Marfan Syndrome diagnosis   MeSH
• Myocarditis diagnosis   MeSH
• Death, Sudden * etiology   prevention & control   MeSH
• Heart Valve Diseases diagnosis   MeSH
• Sports * MeSH
• Long QT Syndrome diagnosis   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Bradycardia diagnosis   etiology   therapy   MeSH
• Electrophysiologic Techniques, Cardiac * methods   standards   trends   MeSH
• Electrocardiography MeSH
• Ventricular Flutter diagnosis   etiology   therapy   MeSH
• Atrial Flutter diagnosis   etiology   therapy   MeSH
• Cardiac Pacing, Artificial methods   standards   trends   MeSH
• Pacemaker, Artificial standards   trends   MeSH
• Humans MeSH
• Cardiac Resynchronization Therapy Devices * standards   trends   MeSH
• Arrhythmias, Cardiac * diagnosis   etiology   prevention & control   MeSH
• Cardiac Electrophysiology methods   standards   trends   MeSH
• Statistics as Topic MeSH
• Tachycardia diagnosis   etiology   therapy   MeSH
• Check Tag
• Humans MeSH