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Author
Malý, Petr 48 Kuchař, Milan 18 Petroková, Hana 15 Kosztyu, Petr 8 Raška, Milan 8 Černý, Jiří 8 Berlec, Aleš 6 Osička, Radim 6 Turánek, Jaroslav 6 Bharadwaj, Shiv 5 Brynda, Jiří 5 Rašková Kafková, Leona 5 Vaňková, Lucie 5 Maly, Petr 4 Marková, Vladimíra 4 Mašek, Josef 4 Schneider, Bohdan 4 Biedermannová, Lada 3 Cerný, Jiří 3 Fábry, Milan 3
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Laboratory of Ligand Engineering Inst... 4 Laboratory of Ligand Engineering Inst... 4 Laboratory of Structural Bioinformati... 3 Department of Biotechnology Jožef Ste... 2 Department of Biotechnology Jožef Ste... 2 Laboratory of Ligand Engineering Inst... 2 School of Biotechnology Jawaharlal Ne... 2 School of Life Sciences Gwangju Insti... 2 Ústav Imunologie LF UP Olomouc ČR 2 1 LF UK a FN Na Bulovce Chirurgická k... 1 1st Faculty of Medicine Charles Unive... 1 1th Department of Neurology Institute... 1 2nd Department of Neurology Institute... 1 3rd Faculty of Medicine and Universit... 1 AVČR Ústav molekulární genetiky Odděl... 1 Ain Shams University Affiliated Saudi... 1 Alexandria University Hospitals and A... 1 Biotechnologický ústav AV ČR Vestec 1 Biotechnologický ústav AV ČR v v i 1 Biotechnologický ústav AV ČR v v i Praha 1
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A : Anatomy 14 B : Organisms 35 C : Diseases 20 D : Chemicals and Drugs 29 E : Analytical, Diagnostic... 24 F : Psychiatry and Psychology 3 G : Phenomena and Processes 18 H : Disciplines and Occupa... 4 I : Anthropology, Educatio... 3 J : Technology, Industry, ... 2 L : Information Science 10 M : Named Groups 4 N : Health Care 11 V : Publication Characteri... 40
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Česká a slovenská neurologie a neuroc... 4 Alergie (Praha, Print) 3 Chemické listy 2 Frontiers in immunology 2 International journal of molecular sc... 2 Klinická imunológia a alergológia 2 Pharmaceutics 2 Postgraduální medicína 2 Proteins 2 Zdravotnické noviny (Avicenum/Mladá f... 2 Acta crystallographica. Section D, Bi... 1 Acta crystallographica. Section F 1 Analytical Cytometry 1 Autoimmunity 1 BioMed research international 1 Biologické listy 1 Bioprospect 1 Biosensors & bioelectronics 1 Briefings in bioinformatics 1 Cells V 1
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Malý, Petr 48 Kuchař, Milan 18 Petroková, Hana 15 Kosztyu, Petr 8 Raška, Milan 8 Černý, Jiří 8 Berlec, Aleš 6 Osička, Radim 6 Turánek, Jaroslav 6 Bharadwaj, Shiv 5 Brynda, Jiří 5 Rašková Kafková, Leona 5 Vaňková, Lucie 5 Maly, Petr 4 Marková, Vladimíra 4 Mašek, Josef 4 Schneider, Bohdan 4 Biedermannová, Lada 3 Cerný, Jiří 3 Fábry, Milan 3
- Organization
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Workplace
Laboratory of Ligand Engineering Inst... 4 Laboratory of Ligand Engineering Inst... 4 Laboratory of Structural Bioinformati... 3 Department of Biotechnology Jožef Ste... 2 Department of Biotechnology Jožef Ste... 2 Laboratory of Ligand Engineering Inst... 2 School of Biotechnology Jawaharlal Ne... 2 School of Life Sciences Gwangju Insti... 2 Ústav Imunologie LF UP Olomouc ČR 2 1 LF UK a FN Na Bulovce Chirurgická k... 1 1st Faculty of Medicine Charles Unive... 1 1th Department of Neurology Institute... 1 2nd Department of Neurology Institute... 1 3rd Faculty of Medicine and Universit... 1 AVČR Ústav molekulární genetiky Odděl... 1 Ain Shams University Affiliated Saudi... 1 Alexandria University Hospitals and A... 1 Biotechnologický ústav AV ČR Vestec 1 Biotechnologický ústav AV ČR v v i 1 Biotechnologický ústav AV ČR v v i Praha 1
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A : Anatomy 14 B : Organisms 35 C : Diseases 20 D : Chemicals and Drugs 29 E : Analytical, Diagnostic... 24 F : Psychiatry and Psychology 3 G : Phenomena and Processes 18 H : Disciplines and Occupa... 4 I : Anthropology, Educatio... 3 J : Technology, Industry, ... 2 L : Information Science 10 M : Named Groups 4 N : Health Care 11 V : Publication Characteri... 40
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- Country
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Journal/source
Česká a slovenská neurologie a neuroc... 4 Alergie (Praha, Print) 3 Chemické listy 2 Frontiers in immunology 2 International journal of molecular sc... 2 Klinická imunológia a alergológia 2 Pharmaceutics 2 Postgraduální medicína 2 Proteins 2 Zdravotnické noviny (Avicenum/Mladá f... 2 Acta crystallographica. Section D, Bi... 1 Acta crystallographica. Section F 1 Analytical Cytometry 1 Autoimmunity 1 BioMed research international 1 Biologické listy 1 Bioprospect 1 Biosensors & bioelectronics 1 Briefings in bioinformatics 1 Cells V 1
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E-resources NLK Online Full text
Open Access Digital Library from 1970-01-01Open Access Digital Library from 1970-01-01
PubMed
38465650
DOI
10.1161/strokeaha.123.045225
Knihovny.cz E-resources
BACKGROUND: Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs). NETs are proposed as a mechanism of resistance to thrombolysis. This study intends to analyze the composition of thrombi retrieved after mechanical thrombectomy, estimate the age and organization of thrombi, and evaluate associations with the use of thrombolysis, antiplatelets, and heparin. METHODS: This retrospective observational study involved 72 samples (44 from cerebral and 28 coronary arteries), which were stained with hematoxylin and eosin, anti-NE (neutrophil elastase) antibody, and anti-histone H2B (histone H2B) antibody, representing different components in NET formation, all detectable during the later stages of NETosis, for histochemical and digital quantification of NET content. The histological and morphological evaluations of the specimens were correlated, through univariate and mediation analyses, with clinical information and therapy administered before intervention. RESULTS: The results demonstrated that the composition of cerebral and coronary thrombi differs, and there were significantly more lytic cerebral thrombi than coronary thrombi (66% versus 14%; P=0.005). There was a considerably higher expression of NETs in the cerebral thrombi as testified by the higher expression of H2B (P=0.031). Thrombolysis was remarkably associated with higher NE positivity (average marginal effect, 6.461 [95% CI, 0.7901-12.13]; P=0.02555), regardless of the origin of thrombi. There was no notable association between the administration of antiaggregant therapy/heparin and H2B/NE amount when adjusted for the thrombus location. Importantly, the age of the thrombus was the only independent predictor of NET content without any mediation of the thrombolytic treatment (P=0.014). CONCLUSIONS: The age of the thrombus is the driving force for NET content, which correlates with impaired clinical outcomes. The therapy that is currently administered does not modify NET content. This study supports the need to investigate new pharmacological approaches added to thrombolysis to prevent NET formation or enhance their disruption, such as recombinant human DNase I (deoxyribonuclease I).
- MeSH
- Extracellular Traps * metabolism MeSH
- Heparin MeSH
- Histones metabolism MeSH
- Humans MeSH
- Neutrophils metabolism MeSH
- Thrombolytic Therapy MeSH
- Thrombosis * drug therapy metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
E-resources NLK Online Full text
Directory of Open Access Journals from 2010Free Medical Journals from 2010
PubMed Central from 2010
Europe PubMed Central from 2010
Open Access Digital Library from 2010-01-01
Open Access Digital Library from 2010-01-01
ROAD: Directory of Open Access Scholarly Resources from 2010
PubMed
38384472
DOI
10.3389/fimmu.2024.1342086
Knihovny.cz E-resources
Non-small cell lung cancer (NSCLC) is largely promoted by a multistep tumorigenesis process involving various genetic and epigenetic alterations, which essentially contribute to the high incidence of mortality among patients with NSCLC. Clinical observations revealed that NSCLC also co-opts a multifaceted immune checkpoint dysregulation as an important driving factor in NSCLC progression and development. For example, a deregulated PI3K/AKT/mTOR pathway has been noticed in 50-70% of NSCLC cases, primarily modulated by mutations in key oncogenes such as ALK, EGFR, KRAS, and others. Additionally, genetic association studies containing patient-specific factors and local reimbursement criteria expose/reveal mutations in EGFR/ALK/ROS/BRAF/KRAS/PD-L1 proteins to determine the suitability of available immunotherapy or tyrosine kinase inhibitor therapy. Thus, the expression of such checkpoints on tumors and immune cells is pivotal in understanding the therapeutic efficacy and has been extensively studied for NSCLC treatments. Therefore, this review summarizes current knowledge in NSCLC tumorigenesis, focusing on its genetic and epigenetic intricacies, immune checkpoint dysregulation, and the evolving landscape of targeted therapies. In the context of current and future therapies, we emphasize the significance of antibodies targeting PD-1/PD-L1 and CTLA-4 interactions as the primary therapeutic strategy for immune system reactivation in NSCLC. Other approaches involving the promising potential of nanobodies, probodies, affibodies, and DARPINs targeting immune checkpoints are also described; these are under active research or clinical trials to mediate immune regulation and reduce cancer progression. This comprehensive review underscores the multifaceted nature, current state and future directions of NSCLC research and treatment.
- MeSH
- B7-H1 Antigen metabolism MeSH
- ErbB Receptors metabolism MeSH
- Phosphatidylinositol 3-Kinases metabolism MeSH
- Carcinogenesis MeSH
- Humans MeSH
- Cell Transformation, Neoplastic MeSH
- Lung Neoplasms * drug therapy genetics MeSH
- Carcinoma, Non-Small-Cell Lung * drug therapy genetics MeSH
- Proto-Oncogene Proteins p21(ras) MeSH
- Receptor Protein-Tyrosine Kinases metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
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Marto, João Pedro
Author Marto, João Pedro ORCID Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece. joao.pedro.seabra.marto@gmail.com
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Strambo, Davide
Author Strambo, Davide Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Ntaios, George
Author Ntaios, George Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Nguyen, Thanh N
Author Nguyen, Thanh N Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Herzig, Roman
Author Herzig, Roman Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Czlonkowska, Anna
Author Czlonkowska, Anna Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Demeestere, Jelle
Author Demeestere, Jelle Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Mansour, Ossama Yassin
Author Mansour, Ossama Yassin Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Salerno, Alexander
Author Salerno, Alexander Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
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Wegener, Susanne
Author Wegener, Susanne Department of Neurology (J.P.M., M.M.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Stroke Centre (D.S., A.S., P.M.), Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Switzerland Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece Department of Neurology, Radiology (T.N.N.), Boston Medical Center, Boston University School of Medicine, MA Department of Neurology (R.H., L.S., D.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic 2nd Department of Neurology (A.C., M.A.K., M.N.), Institute of Psychiatry and Neurology, Warsaw, Poland Neurology Department (J.D., R.L.), Leuven University Hospital, Belgium Alexandria University Hospitals and Affiliated Stroke Network (O.Y.M.), Egypt Department of Neurology (S.W., P.B.), University Hospital of Zurich, Switzerland Stroke Center (C.W.C., G.B.), Neurocenter of Southern Switzerland, EOC, Lugano Stroke Center (M.B, M.A.), Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Switzerland Stroke Centre (E.C.), Geneva University Hospital, Switzerland Department of Neuroradiology (P.M.), Geneva University Hospital, Switzerland Stroke Centre (V.A, L.B., H.G.), University Hospital Basel and University of Basel, Switzerland Stroke Centre (M.B.), Kantonsspital Lucerne, Switzerland Stroke Centre (N.P., S.W.), Hirslanden Hospital, Zurich, Switzerland Department of Neuroradiology (J.N.R.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal Department of Neurology (J.S.-F., R.M., C.M.), Centro Hospitalar Universitário de Coimbra, Portugal Department of Neuroradiology (E.M.), Centro Hospitalar Universitário de Coimbra, Portugal Stroke Unit (A.P.N., P.F.), Hospital de São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal Stroke Unit (T.P.e.M., M.C.D., A.P.), Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neuroradiology (M.A.C.), Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal Department of Neurology (P.C., E.A.), Centro Hospitalar Universitário São João, Porto, Portugal Department of Neuroradiology (L.A.), Centro Hospitalar Universitário São João, Porto, Portugal Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.), Hospital de Braga, Portugal Department of Neurology (L.P., M.R.), Hospital Garcia de Orta, Almada, Portugal Department of Neuroradiology (A.P.A., M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (M.R.), Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal Department of Neurology (A.P.-F, L.R.), Unidade Local de Saúde de Matosinhos, Portugal Department of Neurology (R.V., S.M.), Centro Hospitalar Universitário do Porto, Portugal Stroke Unit (M.C., C.Z.), Azienda Ospedaliera Universitaria Integrata, Verona, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna (A.Z., M.G., S.F., L.M.), Department of Neurology and Stroke Centre, Maggiore Hospital, Bologna, Italy Department of Neurology (M.S., S.L.G.), ASST Papa Giovanni XXIII, Bergamo, Italy Department of Clinical and Experimental Sciences (A.P.), Neurology Clinic, University of Brescia, Italy Department of Neurology and Stroke Unit (D.S.), Azienda Socio Sanitaria Territoriale, Lecco, Italy Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Neuroradiology Unit (R.P.), Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Italy Department of Neurology (C.F., S.B., S.D.), San Gerardo Hospital, Department of Medicine and Surgery and Milan Centre for Neuroscience, University of Milano Bicocca, Monza, Italy Stroke Unit (G.S.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neurology (G.F.), Policlinico Universitario Agostino Gemelli, Rome, Italy Emergency Neurology and Stroke Unit (S.M.), IRCCS Humanitas Clinical and Research Center, Rozzano, Italy Department of Neurology (C.S., S.E.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (M.P., B.M.), Hôpital Fondation Ade Rothschild, Paris, France Department of Interventional Neuroradiology (G.C., F.V.), Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France Neurology (F.L., P.C, F.R.V.), Stroke Unit, Centre Hospitalier Universitaire, Grenoble Alpes, France Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.), Bordeaux University Hospital, France Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.), University Medical Center-Hamburg-Eppendorf, Germany Department of Neurology (F.O.B., J.H.S.), University Hospital Frankfurt, Goethe University, Germany Department of Neurology and Centre for Stroke Research (H.J.A.), Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Germany Department of Neuroradiology (E.S.), Charité-Universitätsmedizin Berlin, Germany Department of Neurology (M.S, W.L., J.F.), St. John's Hospital, Vienna, Austria Departments of Neurology (L.M.-S., M.K.), and Neuroradiology (E.R.G.), Medical University of Innsbruck, Austria Department of Neurology (J.S., L.J.S., J.M.C.), Amsterdam University Medical Centers, Netherlands Department of Neurology (I.v.d.W., J.d.M.), Haaglanden Medical Centre, Hague and Department of Radiology, Leiden University Medical Centre, Netherlands Department of Neurology (S.D.R., F.V.), Universitair Ziekenhuis Brussel, Centre for Neurosciences, Vrije Universiteit Brussel, Belgium Department of Neurology (M.P.R, A.G.), Stroke Unit, Europe Hospitals, Brussels, Belgium Department of Neurology (A.D., F.B.), Centre Hospitalier Universitaire de Charleroi, Belgium Department of Neurology and Stroke Centre (P.C.-C., F.O., P.M.-J.), Hospital Universitario de OctubreInstituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain Department of Neurology and Stroke Centre (A.C.-C., R.V., M.C.M.), Hospital Universitario Ramón y Cajal, Ramon y Cajal Institute for Health Research (IRYCIS), Madrid, Spain Department of Neurology and Stroke (B.F, M.A.d.L., R.R., E.D.D.), Centre Hospital La Paz Institute for Health Research-IdiPAZ (La Paz University Hospital-Universidad Autónoma de Madrid), Spain Department of Neurology (S.P.-S., J.M.), Hospital Universitario Virgen Macarena, Seville, Spain Stroke Centre (F.D-.O.), Hospital General Universitario Gregorio Marañón, Madrid, Spain Stroke Unit (B.F.-P., J.M.-N.), Germans Trias Hospital, Barcelona, Spain Department of Neurology (A.C, A.R.-V., A.R), Comprehensive Stroke Centre, Hospital Clinic from Barcelona, Spain Department of Neurology (O.A.-M, F.H.-F.), Complejo Hospitalario Universitario de Albacete Stroke Unit (H.T.-M.), Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet, Spain Stroke Unit (D.S.-M, M.F.P.), Department of Neurology, Hospital Universitario Miguel Servet, Spain Stroke and Geriatric Medicine (T.H.), Aintree University Hospital, United Kingdom Comprehensive Stroke Service (I.S., R.S.), University College London Hospitals NHS Foundation Trust and Stroke Research Centre, University College London, United Kingdom University College London (D.W.), Queen Square Institute of Neurology, London, United Kingdom Department of Neurology (E.S.K.), Akershus University Hospital, Lørenskog and Department of General Practice, University of Oslo, Norway Department of Clinical Neuroscience (A.N, K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology (A.N, K.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.R.), Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg and Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden Department of Radiology (A.K.), Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic International Clinical Research Centre (R.M., M.C., J.V.) and Department of Neurology, St. Anne ́s University Hospital and Faculty of Medicine at Masaryk University, Brno, Czech Republic Center for Health Research (D.S., M.R, E.H.), Faculty of Medicine, University of Ostrava, Czech Republic Department of Neurology (R.H, S.V.), České Budějovice Hospital, Czech Republic Department of Neurology (O.S., M.P.), Jihlava Hospital, Czech Republic Neurocenter (L.J., Z.E., M.J.), Regional Hospital Liberec, Czech Republic Cerebrovascular Centre (M.K., M.P., P.M.), Na Homolce Hospital, Prague, Czech Republic Department of Neurology (H.P.), Karviná Miners Hospital Inc., Czech Republic Cerebrovascular Centre (A.T, P.J, A.O.), University Hospital in Motol, Prague, Czech Republic Cerebrovascular Centre (M.S., R.H, P.M., L.T.), Central Military Hospital, Prague, Czech Republic Cerebrovascular Centre (J.F., M.S.), General University Hospital, Prague, Czech Republic 1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland Department of Neurology (P.W, T.H., K.S., A.S), University Hospital, Jagiellonian University, Cracow, Poland Department of Neurology (M.W., L.T.-L., B.S.), Institute of Medical Sciences, Medical College of Rzeszow University, Poland Department of Neurology and Stroke (M.B, A.B.), St. John Paul II Western Hospital, Grodzisk Mazowiecki, Poland Department of Neurology (M.D, J.Z.), Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.), Wroclaw Medical University, Poland Department of Neurosurgery and Neurology (M.S.), Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland Stroke Intervention Centre (I.R., P.S.-S.), Department of Neurosurgery and Neurology, Jan Biziel University Hospital, Bydgoszcz, Poland Department of Neurology (B.M.L.-R.), Institute of Medical Sciences, University of Opole, Poland Clinic of Neurology (A.D., J.S., A.S.), Military Institute of Medicine, Warsaw, Poland Department of Neurology (J.Z.), University of Warmia and Mazury, Olsztyn, Poland Department of Radiology (C.W.), Provincial Specialist Hospital, Olsztyn, Poland Department of Neurology (C.T., E.O.T., R.A.R., A.N.), University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila", Romania Department of Radiology (B.D.), University Emergency Hospital Bucharest, Romania Department of Neurology and Stroke Unit (C.P, V.T, S.P.), Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Department of Neurology (A.O.), Eskisehir Osmangazi University, Turkey Ain Shams University Affiliated Saudi German Hospital (M.M., H.E.-S.), Egypt Neuropsychiatry Department (H.A.), Tanta University, Egypt Department of Neurology (J.A.-H.), Ibn Sina Hospital, Kuwait Department of Neurology (I.I.I.), Jaber Al-Ahmad Hospital, Kuwait Department of Neurology (A.G.), School of Medicine, Zanjan University of Medical Sciences, Iran Stroke Unit (S.I.S.), Neurology Department, Hillel Yaffe Medical Center, Hadera, Israel Department of Neurosurgery (P.J., K.E.N, S.T., R.A.), Thomas Jefferson University Hospital, PA Departments of Radiology (G.A.M., P.G.N.), Neurology and Neurosurgery, Grady Memorial Hospital, Atlanta, GA Department of Neurology (A.C.), Henry Ford Hospital, Detroit, MI Comprehensive Stroke Centre and Department of Neurosciences (J.M., M.H., M.K.), Spectrum Health and Michigan State University Department of Neurology (K.N., S.O.), University of Arkansas for Medical Sciences, Little Rock, AR Department of Neurology (M.K.), Upstate University Hospital, NY Department of Neurology (L.M., M.G.A.), University of Kansas Medical Centre Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.), Rutgers, The State University of New Jersey, Newark Department of Neurology (A.M.K.), Wayne State University, Detroit Medical Center, MI Stroke Clinic (V.C.-N, A.A.), Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico Department of Neurology (P.A.), Fundación Valle del Lili, Cali, Colombia Centro de Investigaciones Clínicas (N.L., A.A.), Fundación Valle del Lili, Cali, Colombia Department of Neurology (M.A.V.), Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Péru Hospital General San Juan de Dios (J.D.B.G.), Guatemala Department of Neurology (R.C., R.T.M.), Hospital Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil Ramos Mejía Hospital (S.D.S.), Stroke Unit, Buenos Aires, Argentina St. Luke's Medical Center (P.M.Y.), Global City, Philippines Department of Neurology (S.N., A.G.), Grant Medical College and Sir JJ Hospital, Mumbai, India Department of Neurology (K.-D.S.), National Health Insurance Service Ilsan Hospital, Goyang, Korea School of Biomedical Engineering and Imaging Sciences (G.G.), St Thomas Hospital, King's College London, UK Department of Clinical Therapeutics (G.G.), National and Kapodistrian University of Athens, Greece
E-resources NLK Online Full text
PubMed
36351814
DOI
10.1212/wnl.0000000000201537
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BACKGROUND AND OBJECTIVES: COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19. METHODS: This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT). RESULTS: Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour mortality (OR 2.47; 95% CI 1.58-3.86), and 3-month mortality (OR 1.88; 95% CI 1.52-2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60). DISCUSSION: Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis. TRIAL REGISTRATION INFORMATION: The study was registered under ClinicalTrials.gov identifier NCT04895462.
- MeSH
- Cerebral Hemorrhage complications MeSH
- Stroke * epidemiology therapy diagnosis MeSH
- COVID-19 * complications MeSH
- Endovascular Procedures * adverse effects MeSH
- Fibrinolytic Agents therapeutic use MeSH
- Intracranial Hemorrhages etiology MeSH
- Ischemic Stroke * epidemiology surgery MeSH
- Brain Ischemia * complications epidemiology surgery MeSH
- Cohort Studies MeSH
- Humans MeSH
- Registries MeSH
- Thrombolytic Therapy adverse effects MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
E-resources NLK Online Full text
Medline Complete (EBSCOhost) from 2012-06-01 to 1 year ago
PubMed
37679309
DOI
10.1002/ptr.8000
Knihovny.cz E-resources
Caffeine, which shares consubstantial structural similarity with purine adenosine, has been demonstrated as a nonselective adenosine receptor antagonist for eliciting most of the biological functions at physiologically relevant dosages. Accumulating evidence supports caffeine's beneficial effects against different disorders, such as total cardiovascular diseases and type 2 diabetes. Conversely, paradoxical effects are also linked to caffeine ingestion in humans including hypertension-hypotension and tachycardia-bradycardia. These observations suggest the association of caffeine action with its ingested concentration and/or concurrent interaction with preferential molecular targets to direct explicit events in the human body. Thus, a coherent analysis of the functional targets of caffeine, relevant to normal physiology, and disease pathophysiology, is required to understand the pharmacology of caffeine. This review provides a broad overview of the experimentally validated targets of caffeine, particularly those of therapeutic interest, and the impacts of caffeine on organ-specific physiology and pathophysiology. Overall, the available empirical and epidemiological evidence supports the dose-dependent functional activities of caffeine and advocates for further studies to get insights into the caffeine-induced changes under specific conditions, such as asthma, DNA repair, and cancer, in view of its therapeutic applications.
- MeSH
- Diabetes Mellitus, Type 2 * MeSH
- Hypertension * drug therapy MeSH
- Cardiovascular Diseases * MeSH
- Caffeine pharmacology chemistry MeSH
- Humans MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
E-resources NLK Online Full text
Directory of Open Access Journals from 2022Elsevier Open Access Journals from 2022-01-01
ROAD: Directory of Open Access Scholarly Resources
PubMed
37619953
DOI
10.1016/j.ejps.2023.106568
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The cytokine IL-23 activates the IL-23 receptor (IL-23R) and stimulates the differentiation of naïve T helper (Th) cells into a Th17 cell population that secretes inflammatory cytokines and chemokines. This IL-23/Th17 proinflammatory axis drives inflammation in Crohn's disease and ulcerative colitis and represents a therapeutic target of monoclonal antibodies. Non-immunoglobulin binding proteins based on the Streptococcus albumin-binding domain (ABD) provide a small protein alternative to monoclonal antibodies. They can be readily expressed in bacteria. Lactococcus lactis is a safe lactic acid bacterium that has previously been engineered as a vector for the delivery of recombinant therapeutic proteins to mucosal surfaces. Here, L. lactis was engineered to display or secrete ABD-variants against the IL-17 receptor (IL-17R). Its expression and functionality were confirmed with flow cytometry using specific antibody and recombinant IL-17R, respectively. In addition, L. lactis were engineered into multifunctional bacteria that simultaneously express two binders from pNBBX plasmid. First, binders of IL-17R were combined with binder of IL-17. Second, binders of IL-23R were combined with binders of IL-23. The dual functionality of the bacteria was confirmed by flow cytometry using corresponding targets, namely the recombinant receptors IL-17R and IL-23R or the p19 subunit of IL-23. Binding of IL-17 was confirmed by ELISA. With the latter, 97% of IL-17 was removed from solution by 2 × 109 recombinant bacteria. Moreover, multifunctional bacteria targeting IL-17/IL-17R prevented IL-17A-mediated activation of downstream signaling pathways in HEK-Blue IL-17 cell model. Thus, we have developed several multifunctional L. lactis capable of targeting multiple factors of the IL-23/Th17 proinflammatory axis. This represents a novel therapeutic strategy with synergistic potential for the treatment of intestinal inflammations.
- MeSH
- Albumins metabolism MeSH
- Cytokines * metabolism MeSH
- Immunologic Factors MeSH
- Interleukin-17 metabolism MeSH
- Interleukin-23 chemistry metabolism MeSH
- Lactococcus lactis * genetics metabolism MeSH
- Humans MeSH
- Antibodies, Monoclonal MeSH
- Recombinant Proteins metabolism MeSH
- Carrier Proteins metabolism MeSH
- Inflammation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Daniel Lišková, Veronika
- Kosztyu, Petr
- Kuchař, Milan
- Černý, Jiří
- Bharadwaj, Shiv
- Petroková, Hana
- Vroblová, Eliška
- Křupka, Michal
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Malý, Michal
Author Malý, Michal Laboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia Laboratory of Structural Bioinformatics of Proteins, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV Research Center, Prumyslova, Vestec, Czechia
- Zosinčuková, Tereza
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Directory of Open Access Journals from 2010Free Medical Journals from 2010
PubMed Central from 2010
Europe PubMed Central from 2010
Open Access Digital Library from 2010-01-01
Open Access Digital Library from 2010-01-01
ROAD: Directory of Open Access Scholarly Resources from 2010
PubMed
36569830
DOI
10.3389/fimmu.2022.1066361
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INTRODUCTION: Imprinting broadly neutralizing antibody (bNAb) paratopes by shape complementary protein mimotopes represents a potential alternative for developing vaccine immunogens. This approach, designated as a Non-Cognate Ligand Strategy (NCLS), has recently been used for the identification of protein variants mimicking CD4 binding region epitope or membrane proximal external region (MPER) epitope of HIV-1 envelope (Env) glycoprotein. However, the potential of small binding proteins to mimic viral glycan-containing epitopes has not yet been verified. METHODS: In this work, we employed a highly complex combinatorial Myomedin scaffold library to identify variants recognizing paratopes of super candidate bNAbs, PGT121 and PGT126, specific for HIV-1 V3 loop epitopes. RESULTS: In the collection of Myomedins called MLD variants targeted to PGT121, three candidates competed with gp120 for binding to this bNAb in ELISA, thus suggesting an overlapping binding site and epitope-mimicking potential. Myomedins targeted to PGT126 designated MLB also provided variants that competed with gp120. Immunization of mice with MLB or MLD binders resulted in the production of anti-gp120 and -Env serum antibodies. Mouse hyper-immune sera elicited with MLB036, MLB041, MLB049, and MLD108 moderately neutralized 8-to-10 of 22 tested HIV-1-pseudotyped viruses of A, B, and C clades in vitro. DISCUSSION: Our data demonstrate that Myomedin-derived variants can mimic particular V3 glycan epitopes of prominent anti-HIV-1 bNAbs, ascertain the potential of particular glycans controlling neutralizing sensitivity of individual HIV-1 pseudoviruses, and represent promising prophylactic candidates for HIV-1 vaccine development.
- MeSH
- Epitopes MeSH
- HIV Envelope Protein gp120 MeSH
- HIV Antibodies * MeSH
- HIV-1 * MeSH
- Mice MeSH
- Antibodies, Neutralizing MeSH
- Polysaccharides MeSH
- Broadly Neutralizing Antibodies MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
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Free Medical Journals from 2000 to 2 years agoPubMed Central from 2008
Medline Complete (EBSCOhost) from 2000-01-01 to 1 year ago
Oxford Journals Open Access Collection from 2000
PubMed
35947964
DOI
10.1093/bib/bbac326
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Several new viral infections have emerged in the human population and establishing as global pandemics. With advancements in translation research, the scientific community has developed potential therapeutics to eradicate or control certain viral infections, such as smallpox and polio, responsible for billions of disabilities and deaths in the past. Unfortunately, some viral infections, such as dengue virus (DENV) and human immunodeficiency virus-1 (HIV-1), are still prevailing due to a lack of specific therapeutics, while new pathogenic viral strains or variants are emerging because of high genetic recombination or cross-species transmission. Consequently, to combat the emerging viral infections, bioinformatics-based potential strategies have been developed for viral characterization and developing new effective therapeutics for their eradication or management. This review attempts to provide a single platform for the available wide range of bioinformatics-based approaches, including bioinformatics methods for the identification and management of emerging or evolved viral strains, genome analysis concerning the pathogenicity and epidemiological analysis, computational methods for designing the viral therapeutics, and consolidated information in the form of databases against the known pathogenic viruses. This enriched review of the generally applicable viral informatics approaches aims to provide an overview of available resources capable of carrying out the desired task and may be utilized to expand additional strategies to improve the quality of translation viral informatics research.
- MeSH
- Humans MeSH
- Pandemics MeSH
- Virus Diseases * drug therapy genetics MeSH
- Computational Biology * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
-
Kumar, Geethu S
Author Kumar, Geethu S ORCID Department of Life Science, School of Basic Science and Research, Sharda University, Greater Noida 201310, Uttar Pradesh, India Center for Bioinformatics, Computational and Systems Biology, Pathfinder Research and Training Foundation, Greater Noida 201308, Uttar Pradesh, India
- Moustafa, Mahmoud
- Sahoo, Amaresh Kumar
- Malý, Petr
- Bharadwaj, Shiv
E-resources NLK Online Full text
Directory of Open Access Journals from 2011Free Medical Journals from 2011
PubMed Central from 2011
Europe PubMed Central from 2011
ProQuest Central from 2011-01-01
Open Access Digital Library from 2011-01-01
Open Access Digital Library from 2011-01-01
ROAD: Directory of Open Access Scholarly Resources from 2011
PubMed
35629327
DOI
10.3390/life12050659
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Several therapeutic monoclonal antibodies approved by the FDA are available against the PD-1/PD-L1 (programmed death 1/programmed death ligand 1) immune checkpoint axis, which has been an unprecedented success in cancer treatment. However, existing therapeutics against PD-L1, including small molecule inhibitors, have certain drawbacks such as high cost and drug resistance that challenge the currently available anti-PD-L1 therapy. Therefore, this study presents the screening of 32,552 compounds from the Natural Product Atlas database against PD-L1, including three steps of structure-based virtual screening followed by binding free energy to refine the ideal conformation of potent PD-L1 inhibitors. Subsequently, five natural compounds, i.e., Neoenactin B1, Actinofuranone I, Cosmosporin, Ganocapenoid A, and 3-[3-hydroxy-4-(3-methylbut-2-enyl)phenyl]-5-(4-hydroxybenzyl)-4-methyldihydrofuran-2(3H)-one, were collected based on the ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiling and binding free energy (>-60 kcal/mol) for further computational investigation in comparison to co-crystallized ligand, i.e., JQT inhibitor. Based on interaction mapping, explicit 100 ns molecular dynamics simulation, and end-point binding free energy calculations, the selected natural compounds were marked for substantial stability with PD-L1 via intermolecular interactions (hydrogen and hydrophobic) with essential residues in comparison to the JQT inhibitor. Collectively, the calculated results advocate the selected natural compounds as the putative potent inhibitors of PD-L1 and, therefore, can be considered for further development of PD-L1 immune checkpoint inhibitors in cancer immunotherapy.
- Publication type
- Journal Article MeSH
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