- MeSH
- dítě MeSH
- lidé MeSH
- Streptococcus pyogenes patogenita MeSH
- streptokokové infekce * diagnóza farmakoterapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Geografické názvy
- Česká republika MeSH
Smoldering multiple myeloma (SMM) is an asymptomatic precursor to active multiple myeloma (MM). The aim of this study was to report clinical characteristics and outcomes of patients with SMM stratified based on their risk of progression to MM using the Mayo 20/2/20 criteria. Data were leveraged from the Czech Myeloma Group Registry of Monoclonal Gammopathies (RMG). Key outcomes included progression-free survival from SMM diagnosis to active MM diagnosis or death (PFS), progression-free survival from SMM diagnosis to progression on first line (1 L) MM treatment or death (PFS2), and overall survival (OS). Of 498 patients, 174 (34.9%) were classified as high risk and 324 (65.1%) as non-high risk. Median follow-up was approximately 65 months. During follow-up, more patients in the high-risk vs non-high-risk group received 1 L MM treatment (76.4% vs 46.6%, p < 0.001). PFS, PFS2, and OS were significantly shorter in high-risk vs non-high-risk patients (13.2 vs 56.6 months, p < 0.001; 49.9 vs 84.9 months, p < 0.001; 93.2 vs 131.1 months, p = 0.012, respectively). The results of this study add to the growing body of evidence that patients with high-risk vs non-high-risk SMM have significantly worse outcomes, including OS.
- MeSH
- doba přežití bez progrese choroby MeSH
- doutnající mnohočetný myelom * diagnóza epidemiologie terapie MeSH
- lidé MeSH
- mnohočetný myelom * diagnóza epidemiologie terapie MeSH
- registrace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
Paroxysmal cold hemoglobinuria (PCH) is a rare condition in childhood characterized by complement-mediated premature destruction of red blood cells. PCH is associated with intravascular hemolysis causing hemoglobinuria, which may result in acute kidney injury of various severity. We aimed to retrospectively analyze clinical and laboratory features of children with PCH-associated acute kidney injury received at tertiary Pediatric Hematology and Nephrology Center, University Motol Hospital, Prague, Czech Republic during the period 2016 to 2022. We present here 3 children with PCH-associated acute kidney failure requiring renal replacement therapy. We highlight the association of PCH with kidney disease. Renal parameters and urine examination should be regularly tested in all children with PCH.
- MeSH
- akutní poškození ledvin * komplikace MeSH
- dítě MeSH
- erytrocyty MeSH
- hemolýza MeSH
- lidé MeSH
- nízká teplota MeSH
- paroxysmální hemoglobinurie * komplikace diagnóza MeSH
- retrospektivní studie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Mnohočetný myelom je krevní nádorové onemocnění charakterizované proliferací klonálních plasmatických buněk v kostní dřeni a přítomností paraproteinu v séru a/nebo moči. V posledních letech se pro diagnostiku i pro celý průběh léčby dostává do popředí celotělová zobrazovací metoda pozitronová emisní tomografie (PET) kombinovaná s výpočetní tomografií (PET/CT). Její výhodou je zachycení metabolicky aktivních charakteristických ložisek a dobrá detekce extramedulárních i paramedulárních lézí. Následující text shrnuje společné stanovisko odborníků České společnosti nukleární medicíny ČLS JEP z. s. (ČSNM ČLS JEP) a České myelomové skupiny (CMG) jak k provedení vyšetření PET/CT, tak k jeho hodnocení a reportování. Cílem je sjednotit metodiku vyšetření PET/CT napříč pracovišti v ČR, která bude srozumitelná a jednoznačná.
Multiple myeloma is a blood cancer characterized by proliferation of clonal plasma cells in the bone marrow and the presence of paraprotein in the serum and/or urine. In recent years, whole-body positron emission tomography (PET) imaging combined with computed tomography (PET/CT) has become a preferred imaging technique for diagnosis and treatment. It has the benefit of detecting metabolically active characteristic focuses and good detection of extramedullary and paramedullary lesions. The following text presents the collective opinion of the representatives of the Czech Society of Nuclear Medicine ČLS JEP z.s. (CSNM ČLS JEP) and the Czech Myeloma Group (CMG) on PET/CT as well as on its evaluation and reporting. The aim is to standardize the methodology of PET/CT examination across the Czech Republic, which will be clear and simple to understand.
- Klíčová slova
- extramedulární ložiska, paramedulární ložiska,
- MeSH
- kritéria léčebné odpovědi MeSH
- lidé MeSH
- mnohočetný myelom * diagnostické zobrazování MeSH
- PET/CT metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- směrnice pro lékařskou praxi MeSH
Mnohočetný myelom je krevní nádorové onemocnění charakterizované proliferací klonálních plazmatických buněk v kostní dřeni a přítomností paraproteinu v séru a/nebo moči. V posledních letech se pro diagnostiku i pro celý průběh léčby dostává do popředí celotělová zobrazovací metoda pozitronová emisní tomografie (PET) kombinovaná s výpočetní tomografií (PET/CT). Její výhodou je zachycení metabolicky aktivních charakteristických ložisek a dobrá detekce extramedulárních i paramedulárních lézí. Následující text shrnuje společné stanovisko odborníků České společnosti nukleární medicíny ČLS JEP (ČSNM ČLS JEP) a České myelomové skupiny (CMG) jak k provedení vyšetření PET/CT, tak k jeho hodnocení a reportování. Cílem je sjednotit metodiku vyšetření PET/CT napříč pracovišti v ČR, která bude srozumitelná a jednoznačná.
Multiple myeloma is a blood cancer characterized by proliferation of clonal plasma cells in the bone marrow and the presence of paraprotein in the serum and/or urine. In recent years, whole-body positron emission tomography (PET) imaging combined with computed tomography (PET/CT) has become a preferred imaging technique for diagnosis and treatment. It has the benefit of detecting metabolically active characteristic focuses and good detection of extramedullary and para-medullary lesions. The following text presents the joint standpoint of the representatives of the Czech Society of Nuclear Medicine ČLS JEP (CSNM ČLS JEP) and the Czech Myeloma Group (CMG) regarding PET/CT examination per se as well as its evaluation and reporting. The aim is to standardize the methodology of PET/CT examination across the Czech Republic, which will be clear and simple to understand.
- MeSH
- fluorodeoxyglukosa F18 MeSH
- lidé MeSH
- mnohočetný myelom * diagnostické zobrazování patologie MeSH
- PET/CT * metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- směrnice pro lékařskou praxi MeSH
- Geografické názvy
- Česká republika MeSH
We performed real world evidence (RWE) analysis of daratumumab, lenalidomide and dexamethasone (Dara-Rd) versus lenalidomide and dexamethasone (Rd) treatment in relapsed/refractory multiple myeloma patients (RRMM). In total, 240 RRMM patients were treated with Dara-Rd from 2016 to 2022 outside of clinical trials in all major Czech hematology centers. As a reference, 531 RRMM patients treated with Rd were evaluated. Patients' data were recorded in the Czech Registry of Monoclonal Gammopathies (RMG). Partial response (PR) or better response (ORR) was achieved in significantly more patients in Dara-Rd than in Rd group (91.2% vs. 69.9%; p < 0.001). The median progression free survival (PFS) was 26.9 months in the Dara-Rd and 12.8 months in the Rd group (p < 0.001). Median overall survival (OS) was not reached in the Dara-Rd compared to 27.2 months in the Rd group (p = 0.023). In patients with 1-3 previous treatment lines, there was significant PFS benefit of Dara-Rd compared to Rd (median PFS not reached vs. 13.2 months; p < 0.001). In patients with > 3 previous treatment lines, there was no significant PFS benefit of Dara-Rd treatment (7.8 months vs. 9.9 months; p = 0.874), similarly in patients refractory to PI + IMIDs (11.5 months vs. 9.2 months; p = 0.376). In RWE conditions, the median PFS in RRMM patients treated with Dara-Rd is shorter when compared to clinical trials. In heavily pretreated RRMM patients, efficacy of Dara-Rd treatment is limited; best possible outcomes of Dara-Rd are achieved in minimally pretreated patients.
