Bifidobacteria as a strictly anaerobic gram-positive bacteria, is widely distributed in the intestine, vagina and oral cavity, and is one of the first gut flora to colonize the early stages of life. Intestinal flora is closely related to health, and dysbiosis of intestinal flora, especially Bifidobacteria, has been found in a variety of diseases. Numerous studies have shown that in addition to maintaining intestinal homeostasis, Bifidobacteria may be involved in diseases covering all parts of the body, including the nervous system, respiratory system, genitourinary system and so on. This review collects evidence for the variation of Bifidobacteria in typical diseases among various systems, provides mild and effective therapeutic options for those diseases that are difficult to cure, and moves Bifidobacteria from basic research to further clinical applications.
- MeSH
- Bifidobacterium * MeSH
- lidé MeSH
- prsty nohy MeSH
- střeva * mikrobiologie MeSH
- vagina mikrobiologie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
PURPOSE OF THE STUDY Total arthroplasty of the first metatarsophalangeal joint is one of the surgical treatment options for patients with advanced hallux rigidus. This study evaluates the pressure changes in the propulsion phase of the gait cycle using dynamic pedobarography after the total arthroplasty of the first metatarsophalangeal joint by Medin PH-Flex and their comparison with the control groups of patients with hallux rigidus and with asymptomatic patients. MATERIAL AND METHODS Dynamic pedobarograph was used to evaluate 15 first MTP joint replacements by Medin PH-Flex implants in 12 female patients, the average time since joint replacement was 3.5 years (1.5 to 5.5 years). The control group consisted of 13 forefeet in 12 patients with hallux rigidus of Grade 3 and Grade 4 according to the Coughlin classification and 17 healthy patients with no clear foot deformity, i.e. of a total of 34 forefeet. A zone for each metatarsal (M1-M5) and the big toe area (T1) were defined with the use of an integrated software. The difference between the pressure under the big toe area and the first metatarsal bone - hallux stiffness (T1-M1) and the forefoot balance parameter, i.e. the difference between the pressures under the medial and lateral half of the forefoot ((M1+M2)-(M3+M4+M5)), was obtained. The parameters were evaluated for each group during the propulsion phase of the gait, i.e. from 55% to 100% of the stance phase and from 75% to 100% of the stance phase, i.e. that part of propulsion when the greatest pressure is exerted on the big toe. RESULTS For the HS parameter (T1-M1) in 55% to 100% of the stance phase, the median value was -0.66 ± 1.22 (-1.90 to 1.45) in the control group, -0.85 ± 1.94 (-1.40 to 3.80) in patients with hallux rigidus, and -0.10 ± 1.48 (-1.30 to 2.40) in patients after the first MTP joint replacement. The median forefoot balance parameter from 55% of the stance phase was -3.48 ± 2.45 (-6.90 to 0.68) in healthy patients and -4.43 ± 2.72 (-6.98 to 0.23) in hallux rigidus patients. In patients after the joint replacement, the value was -3.00 ± 2.46 (-6.20 to 0.40). The data were statistically analysed by the Dunnett's and Tukey's multiple comparison tests. The hallux stiffness parameter showed a significant improvement after the joint replacement compared to patients with hallux rigidus (p<0.0001). No statistical significance was confirmed when comparing the joint replacement cases and the healthy patients from the control group (p=0.0007 and p=0.0010, respectively). As concerns the forefoot balance parameter, a significant difference was reported in patients with joint replacement compared to healthy patients from the control group and patients with hallux rigidus (p <0.0001). DISCUSSION The published pedobarographic studies differ in terms of the methodology used, the patient population and the parameters examined. The pedobarographic studies after the replacement of the first MTP joint or after its arthrodesis present inconclusive outcomes. According to the available literature, the joint replacement has the potential to improve mediolateral forefoot loading and to partially restore the weight-bearing function of the first ray. Our analysis of the HS parameter suggests that the MTP joint replacement can improve the big toe function compared to patients with hallux rigidus but fails to achieve the functional outcomes of healthy patients. When evaluating the forefoot balance (FB) parameter, we can observe less loading on the lateral half of the forefoot in the propulsion phase compared to hallux rigidus. Nonetheless, the joint replacement is unable to restore the physiological loading of the foot. CONCLUSIONS The first MTP joint replacement has the potential to improve forefoot function and to bring it closer to that of a healthy person, even though achieving physiological loading of the forefoot is unrealistic. Additional studies will be needed to confirm that the indication for the first MTP joint replacement is justified in hallux rigidus in terms of the effect on forefoot biomechanics. Key words: hallux rigidus, total replacement of the first MTP joint, dynamic pedobarography, footscan.
- MeSH
- biomechanika MeSH
- chůze (způsob) MeSH
- hallux rigidus * chirurgie MeSH
- lidé MeSH
- noha (od hlezna dolů) MeSH
- palec nohy * MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- MeSH
- hallux valgus * chirurgie MeSH
- lidé MeSH
- palec nohy patologie MeSH
- Check Tag
- lidé MeSH
- MeSH
- amputace MeSH
- gangréna terapie MeSH
- hojení ran MeSH
- komplikace diabetu MeSH
- prsty nohy chirurgie MeSH
- výsledek terapie MeSH
- Publikační typ
- kazuistiky MeSH
- Klíčová slova
- Charcotova neuroosteoartropatie,
- MeSH
- diabetická noha ošetřování terapie MeSH
- hojení ran MeSH
- komplikace diabetu MeSH
- nedostatek vitaminu D terapie MeSH
- neuropatická artropatie diagnostické zobrazování MeSH
- podiatrie MeSH
- prsty nohy patologie MeSH
- teplota kůže MeSH
- termometrie metody MeSH
- vředy na noze (od hlezna dolů) ošetřování terapie MeSH
- změny tělesné teploty MeSH
Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with a spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions. We report a series of 33 cases of putative calcified chondroid mesenchymal neoplasms, mostly referred for expert consultation out of concern for malignancy. Patients included 17 males and 16 females, with a mean age of 51.3 years. Anatomic locations include the hands and fingers, feet and toes, head and neck, and temporomandibular joint; 1 patient presented with multifocal disease. Radiologic review showed soft tissue masses with variable internal calcification, which occasionally scalloped bone but in all cases appeared indolent/benign. Tumors had a mean gross size of 2.1 cm and a homogenous rubbery to fibrous/gritty tan-white cut surface. Histology demonstrated multinodular architecture with a prominent chondroid matrix and increased cellularity towards the periphery of the nodules. The tumor cells were polygonal with eccentric nuclei and bland cytologic features and showed a variable amount of increased spindled / fibroblastic forms in the perinodular septa. The majority of cases had notable grungy and/or lacy calcifications. A subset of cases demonstrated at least focal areas of increased cellularity and osteoclast-like giant cells. Herein, we confirm the distinct morphologic and clinicopathologic features associated with this entity with the largest series to date, with a focus on practical diagnostic separation from similar chondroid neoplasms. Awareness of these features is critical in avoiding pitfalls, including a malignant diagnosis of chondrosarcoma.
- MeSH
- chondrosarkom * patologie MeSH
- chrupavka patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory kostí * diagnostické zobrazování genetika patologie MeSH
- nádory z pojivové a měkké tkáně * diagnostické zobrazování genetika MeSH
- prsty nohy patologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- diabetická noha * diagnóza terapie MeSH
- dolní končetina patologie MeSH
- hojení ran MeSH
- lidé středního věku MeSH
- lidé MeSH
- nedostatek vitaminu D diagnóza terapie MeSH
- prsty nohy patologie MeSH
- termometrie metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- Klíčová slova
- pedikúra, nehtové rovnátko,
- MeSH
- lidé MeSH
- ošetřovatelská péče metody MeSH
- péče o kůži metody MeSH
- prsty nohy patologie MeSH
- výztuhy MeSH
- zarostlé nehty * ošetřování MeSH
- Check Tag
- lidé MeSH
Verukózní útvar na plosce – verukózní karcinom plosky. Stručný přehled Autoři předkládají případ 64letého muže s 20 let trvajícím verukózním útvarem na pravé plosce. Histopatologické vyšetření potvrdilo diagnózu dlaždicobuněčného karcinomu charakteru verukózního karcinomu. Práce poskytuje přehled současných poznatků o tomto onemocnění.
Verrucous Tumor of the Sole – Verrucous Carcinoma of the Sole. Minireview The authors describe a case of a 64-year-old man with a verrucous lesion on the right sole, that had been present for 20 years. The biopsy confirmed the diagnosis of squamous cell carcinoma of verrucous type. The paper provides an overview of current knowledge of this disease.
- MeSH
- amputace MeSH
- biopsie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfadenopatie diagnostické zobrazování MeSH
- noha (od hlezna dolů) anatomie a histologie patologie MeSH
- prsty nohy chirurgie MeSH
- třísla diagnostické zobrazování patologie MeSH
- verukózní karcinom * chirurgie diagnóza terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Častým problémem dolních končetin dětí i dospělých jsou zarůstající a stáčející se nehty.
Ingrown and curved toenails are among common lower limb problems in both children and adults. They may lead to painful complications and, not uncommonly, to permanent changes in the nail bed and lateral nail folds. The big toe is affected most commonly, although the problem may occur in all toes. A number of procedures have been described for correcting toenails, using either conservative or surgical approaches. Paediatricians are typically the first contact for patients suffering from toenail problems. These can be acute, resulting from a one-off improper nail trimming procedure or injury, and chronic which the parents of young patients are usually unable to deal with. In the past, the vast majority of patients were referred to surgical services since, in the pre-revolution era, contemporary techniques of correcting toenails were unavailable in this country. There are various conservative techniques for the treatment of ingrown toenails, including orthonyxia, which is the correction of toenails with braces. It is the goal of every foot care specialist to manage as many cases as possible with non-invasive procedures and, in particular, in a painless manner whenever it is feasible to proceed in that way.
