The time course of iodine excretion in adult male rats substantially differs from bromine excretion. Bromine is excreted at a single rate, whereas iodine evinces two excretion rates. Even a strong increase in bromide intake in experimental animals failed to affect the rate of iodine excretion but it lowered the fraction of iodine accumulated in the thyroid gland by 20% probably by affecting the transport of iodide into the thyroid gland.
- MeSH
- brom metabolismus MeSH
- bromidy aplikace a dávkování farmakologie MeSH
- celotělové počítání MeSH
- injekce subkutánní MeSH
- izotopové značení MeSH
- jod metabolismus MeSH
- krysa rodu Rattus MeSH
- poločas MeSH
- potkani Wistar MeSH
- radioisotopová scintigrafie MeSH
- radioizotopy jodu MeSH
- štítná žláza diagnostické zobrazování metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- brom MeSH
- bromidy MeSH
- jod MeSH
- radioizotopy jodu MeSH
In experiments with rats, we have found that at enhanced intake of bromide, bromine does not replace chlorine in the thyroid; it replaces iodine. Under our experimental conditions, more than one-third of the iodine content in the thyroid was replaced by bromine. In the thyroid, bromine probably remained in the form of bromide and, in proportional to its increased concentration, the production of iodinated thyronines decreased, with the sum of the iodine and bromine concentrations being constant at the value of 20.51 +/- 1.16 mumol/g dry wt of the thyroid. In contrast to other organs, the biological behavior of bromine in the thyroid is not similar to the biological behavior of chlorine but resembles more that of iodine.
- MeSH
- brom metabolismus farmakokinetika MeSH
- bromidy aplikace a dávkování metabolismus farmakokinetika MeSH
- chlor metabolismus farmakokinetika MeSH
- jod metabolismus farmakokinetika MeSH
- krysa rodu Rattus MeSH
- lékové interakce MeSH
- potkani Wistar MeSH
- štítná žláza metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- brom MeSH
- bromidy MeSH
- chlor MeSH
- jod MeSH
