Pharmaceutical care for patients with sore throat not requiring medical attention Counsultancy in self-treatment of mild health problems is one of the dominant aspects of providing pharmaceutical care, especially in pharmacy practice. A sore throat is one of the most common reasons for visiting a pharmacy. According to current knowledge, the biggest pitfall of sore throat management is the systematic and reliable classification of patients into uncomplicated and potentially complicated cases, which should ideally take place at the level of pre-medical care, i.e. in a pharmacy. For this purpose, the practical use of the self-treatment algorithm in the therapy of sore throat was presented in the article. The introduction of a systematic algorithm into pharmacy practice could contribute to higher efficacy of the provided care and reduce the risk of overlooking warning symptoms (red flags). The article also provides an overview of over the counter therapeutic options for sore throat.

• Klíčová slova
• Pharyngitis, pharmaceutical care., self-treatment algorithm, sore throat,
• MeSH
• algoritmy MeSH
• farmaceutické služby MeSH
• faryngitida * farmakoterapie   terapie   MeSH
• léky bez předpisu terapeutické užití   MeSH
• lidé MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• léky bez předpisu MeSH

Pain and possibilities of its self-treatment - what can be recommended in a pharmacy? Pain is one of the most common health problems for which patients seek help in the pharmacy. Pharmacists and pharmaceutical assistants are the most easily approachable healthcare professionals with deep pharmacotherapeutic knowledge and therefore are able to recommend appropriate pain self-medication including non-pharmacological therapy based on evaluation of patient´s problems and other factors. This article summarizes mainly pharmacological pain treatment options with currently available over-the-counter medicines, also some non-pharmacological recommendations and tries to emphasize rational approach in terms of safety of pharmacotherapy (adverse reactions, dosing). The aim of this article is to provide an evidence-based medicine overview of therapeutic options and a guideline for approach to treatment of all types of pain appropriate for self-medication in the pharmacy.

• Klíčová slova
• Pain, non -opioid analgesics, non-opioid analgesics., pain, self-treatment,
• MeSH
• analgetika terapeutické užití   MeSH
• bolest farmakoterapie   MeSH
• léky bez předpisu terapeutické užití   MeSH
• lidé MeSH
• management bolesti metody   MeSH
• samoléčba * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• analgetika MeSH
• léky bez předpisu MeSH

Rhinitis and Allergic Rhinitis - self-medication options Rhinitis is one of the common diseases that the patient often does not consider necessary to consult a doctor and turns directly to the pharmacist in the pharmacy, who is usually much more accessible to him. It is definitely not appropriate to consider the rhinitis. The pharmacist's role in self-medication therefore consists in trying to determine from the patient's description of his troubles what type of rhinitis it may be, to assess the degree of severity and to decide on the necessity of intervention by a doctor, or the recommendation of a therapeutic procedure with over-the-counter medicinal products. In the case of self-medication, choose the most suitable product with maximum effect and minimum risk and explain the correct handling of it.

• Klíčová slova
• rhinitis, allergic rhinitis, self-medication,
• MeSH
• alergická rýma * farmakoterapie   MeSH
• léky bez předpisu terapeutické užití   MeSH
• lidé MeSH
• rinitida farmakoterapie   MeSH
• samoléčba * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• léky bez předpisu MeSH

BACKGROUND: Venotonics are a class of therapeutically active molecules that have vaso-protective effects. They are used to alleviate venous diseases and disorders, particularly venous insufficiency. We compared the composition of prescription versus over-the-counter (OTC) venotonics using high-performance liquid chromatography with UV detection (HPLC-DAD) and simulating their digestion using a static digestive model. METHODS: From each drug, five tablets were weighed. A homogenate was prepared, and 25 mg of crushed homogenized tablets were weighed into 25 ml volumetric flasks. Dissolved in MeOH and added two drops of saturated NaOH solution. The samples were filtered into vials (Teflon, 0.45 μm) and used for analysis. An Ultimate 3000 HPLC system (Thermo Fisher Scientific, Waltham, MA, USA) consisting of a quaternization pump, autosampler, column thermostat and DAD (UV/VIS detector) was used. The composition of the mobile phase proceeded in a linear gradient from 30% methanol and 70% phosphoric acid (0.15%) in water at time t=0 min. to 80% methanol and 20% phosphoric acid (0.15%) at time t=15 min., at a constant mobile phase flow rate of 1.2 mL/min. Detection was performed using a DAD detector in the 190-450 nm wavelength range. The content of monitored flavonoids was calculated from peaks at a wavelength of 277 nm, in which both flavonoids have their absorption maxima. The static digestive model was used to simulate the digestive phase from the oral cavity to the corresponding intestinal phase. RESULTS: The content of diosmin and hesperidin (mg per table) for a prescription drug: Detralex: 480 mg, 26 mg. The content of diosmin and hesperidin (mg per tablet) for OTC drugs: Venostop: 502 mg, 48 mg, Diosminol: 520 mg, 50 mg, Devenal: 496 mg, 49 mg, Diohes: 493 mg, 46 mg. Digestion did not affect the solubility of all tested drugs. The active substances could not be determined in the non-alkalized sample. After alkalization, part of the insoluble matter was visibly dissolved and converted to a yellow flavonoid complex. Neither diosmin nor hesperidin could be identified afterwards. CONCLUSIONS: Our experimental results show that the contents of both listed active substances, diosmin and hesperidin, met the declared amounts in all tested medicaments. Digestion simulation showed identical behaviour in prescription and OTC venotonics. The active substances could not be determined in the non-alkalized sample. Digestion did not affect the solubility of the tested drugs.

• MeSH
• biologické modely MeSH
• diosmin analýza   MeSH
• hesperidin analýza   MeSH
• léky bez předpisu * chemie   MeSH
• léky na předpis analýza   chemie   MeSH
• lidé MeSH
• tablety MeSH
• vysokoúčinná kapalinová chromatografie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• diosmin MeSH
• hesperidin MeSH
• léky bez předpisu * MeSH
• léky na předpis MeSH
• tablety MeSH

Medicines for self-medication (over-the-counter, OTC) are available through pharmacies, in some countries they are also available in supermarkets and other outlets. The use of OTC in European Union countries shows some differences at national level, in pharmacies and in patients preference. This study aimed to completing the lists of marketed OTC in Czech Republic and Greece. Next topics are: finding out the real range of OTC products offered by pharmacies, finding and evaluating number of packages sold in pharmacies in 20 particular common OTC in 2016, and indentification of factors influencing the sales. Web pages of national drug authorities (Czech Republic, Greece) were searched to complete lists of marketed OTC in each country. Data on range of OTC drugs and sales of them were extracted from computer systems (Czech Republic) and other types of documents (Greece) kept in pharmacies. The percentage of the real range of OTC products in pharmacies was calculated as the ratio to the number of OTC in national lists. Numbers of sold packages were compared among pharmacies. Classification system ATC (anatomical/therapeutical/chemical) was employed to present findings in all parts of the research. The Czech list contained 1,160 of marketed OTC in 10 ATC (1st level), with the maximum in ATC R (243 drugs). The Greek list contained 1,254 OTC in 13 ATC (1st level), with the maximum in ATC D (272 drugs). In lists of both countries, there were detected 86 drugs identical in 9 ATC (1st level). At least one OTC in each of 10 listed ATC was found in Czech pharmacies as a part of range of products, the range of OTC in Greek pharmacies comprised 11 ATC. The highest sales (year 2016) were found in ATC R (drug ACC long tbl eff) in CR and in ATC A (drug: Imodium cps) in Greece. The differences in the range of OTC drugs and in their sales were found between Czech Republic and Greece, and between types of pharmacies inside each country. Factors influencing them were detected: ownership of the pharmacy, locality (number of inhabitants). OTC drugs pharmacy Czech Republic Greece.

• Klíčová slova
• Czech Republic, Greece, OTC drugs, pharmacy,
• MeSH
• lékárny * MeSH
• léky bez předpisu zásobování a distribuce   MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Geografické názvy
• Česká republika MeSH
• Řecko MeSH
• Názvy látek
• léky bez předpisu MeSH

INTRODUCTION: Effective management of seasonal and pandemic influenza is a high priority internationally. Guidelines in many countries recommend antiviral treatment for older people and individuals with comorbidity at increased risk of complications. However, antivirals are not often prescribed in primary care in Europe, partly because its clinical and cost effectiveness has been insufficiently demonstrated by non-industry funded and pragmatic studies. METHODS AND ANALYSIS: Antivirals for influenza-Like Illness? An rCt of Clinical and Cost effectiveness in primary CarE is a European multinational, multicentre, open-labelled, non-industry funded, pragmatic, adaptive-platform, randomised controlled trial. Initial trial arms will be best usual primary care and best usual primary care plus treatment with oseltamivir for 5 days. We aim to recruit at least 2500 participants ≥1 year presenting with influenza-like illness (ILI), with symptom duration ≤72 hours in primary care over three consecutive periods of confirmed high influenza incidence. Participant outcomes will be followed up to 28 days by diary and telephone. The primary objective is to determine whether adding antiviral treatment to best usual primary care is effective in reducing time to return to usual daily activity with fever, headache and muscle ache reduced to minor severity or less. Secondary objectives include estimating cost-effectiveness, benefits in subgroups according to age (<12, 12-64 and >64 years), severity of symptoms at presentation (low, medium and high), comorbidity (yes/no), duration of symptoms (≤48 hours/>48-72 hours), complications (hospital admission and pneumonia), use of additional prescribed medication including antibiotics, use of over-the-counter medicines and self-management of ILI symptoms. ETHICS AND DISSEMINATION: Research ethics committee (REC) approval was granted by the NRES Committee South Central (Oxford B) and Clinical Trial Authority (CTA) approval by The Medicines and Healthcare products Regulatory Agency. All participating countries gained national REC and CTA approval as required. Dissemination of results will be through peer-reviewed scientific journals and conference presentations. TRIAL REGISTRATION NUMBER: ISRCTN27908921; Pre-results.

• Klíčová slova
• adaptive clinical trial, cost-benefit analysis, influenza, oseltamivir, primary healthcare,
• MeSH
• adaptivní klinické zkoušky jako téma MeSH
• analýza nákladů a výnosů MeSH
• antivirové látky ekonomika   terapeutické užití   MeSH
• bolesti hlavy virologie   MeSH
• časové faktory MeSH
• chřipka lidská komplikace   farmakoterapie   prevence a kontrola   MeSH
• činnosti denního života MeSH
• horečka virologie   MeSH
• hospitalizace MeSH
• léky bez předpisu terapeutické užití   MeSH
• léky na předpis terapeutické užití   MeSH
• lidé MeSH
• multicentrické studie jako téma MeSH
• myalgie virologie   MeSH
• oseltamivir ekonomika   terapeutické užití   MeSH
• péče o sebe MeSH
• pneumonie virologie   MeSH
• pragmatické klinické studie jako téma * MeSH
• určení symptomu MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• protokol klinické studie MeSH
• Názvy látek
• antivirové látky MeSH
• léky bez předpisu MeSH
• léky na předpis MeSH
• oseltamivir MeSH

BACKGROUND: Acne is common among young people. OBJECTIVE: To describe the burden, management and sources of advice of acne in a representative sample of young people in Europe. METHODS: This cross-sectional survey was conducted in a representative sample of individuals aged 15-24 years from Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n = 3099). RESULTS: Most individuals considered their acne (all severity stages) to be no/minor problem, although 29.7% considered it a major problem/burden. Over-the-counter (OTC) topical treatments were used more frequently than prescribed treatments. Acne was diagnosed by physicians in 47.6% of cases; other health professionals (nurses, pharmacists) or patients accounted for the remainder of diagnoses. Physicians were the source of acne information in just over one-quarter of cases (27.0%). The vast majority of advice was from friends/family and the Internet. CONCLUSION: Almost one-third of young people consider acne to be a major problem/burden. Fewer than half of acne diagnoses are made by a physician, and acne is often self-managed using OTC treatments.

• MeSH
• acne vulgaris diagnóza   farmakoterapie   epidemiologie   psychologie   MeSH
• dospělí MeSH
• internet MeSH
• léky bez předpisu terapeutické užití   MeSH
• léky na předpis terapeutické užití   MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• percepce * MeSH
• přátelé MeSH
• prevalence MeSH
• průřezové studie MeSH
• průzkumy a dotazníky MeSH
• rodina MeSH
• samoléčba MeSH
• vzdělávání pacientů jako téma metody   MeSH
• zdraví - znalosti, postoje, praxe * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Evropa epidemiologie   MeSH
• Názvy látek
• léky bez předpisu MeSH
• léky na předpis MeSH

WHAT IS KNOWN AND OBJECTIVE: Polypharmacy has a significant impact on patients' health with overall expenditure on over-the-counter (OTC) medicines representing a substantial burden in terms of cost of treatment. The aim of this study, which was conducted within the framework of a European Project funded by the European Union under the Seventh Framework Programme and was entitled OTC-SOCIOMED, was to report on possible determinants of patient behaviour regarding the consumption of medicines, and particularly OTCs, in the context of primary care. METHODS: A multicentre, cross-sectional study was designed and implemented in well-defined primary healthcare settings in Cyprus, the Czech Republic, France, Greece, Malta and Turkey. Patients completed a questionnaire constructed on the basis of the theory of planned behaviour (TPB), which was administered via face-to-face interviews. RESULTS AND DISCUSSION: The percentage of patients who had consumed prescribed medicines over a 6-month period was consistently high, ranging from 79% in the Czech Republic and 82% in Turkey to 97% in Malta and 100% in Cyprus. Reported non-prescribed medicine consumption ranged from 33% in Turkey to 92% in the Czech Republic and 97% in Cyprus. TPB behavioural antecedents explained 43% of the variability of patients' intention to consume medicines in Malta and 24% in Greece, but only 3% in Turkey. Subjective norm was a significant predictor of the intention to consume medicines in all three countries (Greece, Malta and Turkey), whereas attitude towards consumption was a significant predictor of the expectation to consume medicines, if needed. WHAT IS NEW AND CONCLUSION: This study shows that parameters such as patients' beliefs and influence from family and friends could be determining factors in explaining the high rates of medicine consumption. Factors that affect patients' behavioural intention towards medicine consumption may assist in the formulation of evidence-based policy proposals and inform initiatives and interventions aimed at increasing the appropriate use of medicines.

• Klíčová slova
• over-the-counter medicines, patients, prescribing, primary health care, theory of planned behaviour,
• MeSH
• dospělí MeSH
• lékařská praxe - způsoby provádění statistika a číselné údaje   MeSH
• lékařství statistika a číselné údaje   MeSH
• léky bez předpisu terapeutické užití   MeSH
• léky na předpis terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• primární zdravotní péče statistika a číselné údaje   MeSH
• průřezové studie MeSH
• průzkumy a dotazníky MeSH
• úmysl MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• pozorovací studie MeSH
• Geografické názvy
• Evropa MeSH
• Názvy látek
• léky bez předpisu MeSH
• léky na předpis MeSH

The social sciences within health care and pharmacy provide various points of view on issues often managed by professionals both inside and outside of the health care system. This multidisciplinary perspective often leads to divergent views and sometimes seemingly contradictory viewpoints and solutions. This paper is devoted to the opinions and attitudes of Czech citizens on selected issues of healthcare and pharmacy, the elucidation of which could be a source for understanding the relationships among participants in our pluralist health care system as a whole. This article presents the results of a sociological survey featuring a representative sample in terms of gender, age and region of 1,797 respondents from the Czech population aged 15 and over. The research is focused on the issues of self-medication, choice of pharmacy, out of pocket expenditures on prescription drugs and over-the-counter medicines, experiences with side effects and finally an evaluation of patient comprehension of information leaflets accompanying health care products. According to the results presented here, at the onset of a health problem most of the population tries to treat the condition themselves before seeing a doctor (54.1% always, 30.9% sometimes). Over-the-counter drugs are purchased generally in classic pharmacies without self-service (96.1%). The choice of pharmacy is determined primarily by proximity, with much less importance placed on personal experience or lower price. According to the survey, Czechs spend around 150 CZK (€ 5.9) for over-the-counter medicines and around 143 CZK (€ 5.6) for prescription drugs per month; 77.9% of Czech citizens were shown to understand the information provided on package leaflets. These data help to understand the perception, orientation and behavior of the patient in the healthcare system, with the ultimate goal of leading to higher system effectiveness as well as greater satisfaction for all parties involved.

• MeSH
• balení léků MeSH
• dospělí MeSH
• léky bez předpisu škodlivé účinky   terapeutické užití   MeSH
• léky na předpis terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• motivace MeSH
• postoj * MeSH
• samoléčba MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH
• Názvy látek
• léky bez předpisu MeSH
• léky na předpis MeSH

The use of OTC (over-the-counter) drugs containing Ibuprofen and Paracetamol in solid peroral dosage forms was researched. The questionnaire was distributed in 6 pharmacies in Athens, pharmacists interviewed the patients and recorded the answers from June to August 2014. Data from 50 patients for each substance were gathered and analyzed. The most of purchasers of Paracetamol bought it repeatedly (70.00% of respondents); Ibuprofen was preferred to be used in treating headache (81.82% of repeated users, 35.29% of the first time users), and both of the researched drugs were used with almost equal frequency in treating toothache and muscle and joint pain. Ibuprofen is used to treat awider range of symptoms than Paracetamol. People buying Paracetamol for the first time assume that it is free of side effects (73.33%) and people using it repeatedly did not observe any side effects (88.57%). The results were compared with the same research performed in the Czech Republic several years ago. Differences were detected in expecting side effects of Paracetamol (26.67% in Greece, 54.84% in the CR) and in using Ibuprofen to treat muscle and joint pain (17.65% in Greece, 47.60% in the CR).Key words: self-medication paracetamol ibuprofen Greece.

• MeSH
• ibuprofen škodlivé účinky   terapeutické užití   MeSH
• léky bez předpisu terapeutické užití   MeSH
• lidé MeSH
• paracetamol škodlivé účinky   terapeutické užití   MeSH
• průzkumy a dotazníky MeSH
• samoléčba MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Geografické názvy
• Česká republika MeSH
• Řecko MeSH
• Názvy látek
• ibuprofen MeSH
• léky bez předpisu MeSH
• paracetamol MeSH