Spontaneous regression of cysts of the cavum septi pellucidi (CSP) and cavum vergae (CV) is rare and little discussed. The authors present their case report of this phenomenon following a severe headache in a 23-year-old woman, in whom magnetic resonance imaging (MRI) had previously confirmed significant thinning of the left lateral cyst wall. We consider this finding to be a possible predisposing factor to rupture and the spontaneous regression of such cysts. In addition to the mechanism of cyst regression, the interrelated causes of their expansion and formation will be discussed.

• MeSH
• cysty * diagnostické zobrazování   chirurgie   MeSH
• dospělí MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• mladý dospělý MeSH
• septum pellucidum * diagnostické zobrazování   chirurgie   patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

OBJECTIVE: Cysts of the Cavum septi pellucidi (CSP), cavum vergae (CV) and cavum veli interpositi (CVI) are anterior midline intracranial findings which are typically incidental - only rarely do we encounter symptomatic cysts of this type. Only a quite small number of these cysts series have been published, controversies regarding optimal management still exist. PATIENTS AND METHODS: This is a retrospective study of 10 patients treated at 2 clinics between 2002-2018. 9 patients underwent surgery and 1 is under long-term monitoring. Apart from demographic data, the study analyzed symptoms, cyst size and progression over time, ventricle size, complications, and treatment modality. RESULTS: CSP with CV was found in 8 cases with 1 case each of CSP and CVI. The study comprised 6 men and 4 women, including 4 children. The mean follow-up time was 43.4 months. The average cyst size was 20.4 mm in CSP and 19.8 mm in CV; the CVI was 33 mm. Headache was most commonly reported (70%) followed by behavioral disturbance (30%). Disturbance in memory, psychomotor development, school performance, visual acuity, and vomiting was variously noted in 20%. The prevailing symptom was headache in adults and behavioral and autonomic disturbance in children. Postoperatively, cysts had reduced by an average of 44.3% while the ventricles remained unchanged. Symptoms resolved in all cases with residual problems in patients presenting with memory loss. No complications were noted. CONCLUSION: Endoscopic fenestration is the method of choice in the treatment of symptomatic midline cysts. We recommend that any further research focuses on precisely establishing their clinical presentation, particularly neuropsychological symptoms.

• Klíčová slova
• Endoscopy, Outcome, Septum pellucidum, Velum interpositum, cavum vergae,
• MeSH
• cysty centrálního nervového systému diagnostické zobrazování   patofyziologie   chirurgie   MeSH
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• mladiství MeSH
• mladý dospělý MeSH
• nádory mozku diagnostické zobrazování   patofyziologie   chirurgie   MeSH
• neuroendoskopie metody   MeSH
• předškolní dítě MeSH
• retrospektivní studie MeSH
• senioři MeSH
• septum pellucidum diagnostické zobrazování   chirurgie   MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• audiovizuální média MeSH
• časopisecké články MeSH
• multicentrická studie MeSH

Recent data suggest that there is interaction between peripheral angiotensin II and nitric oxide. However, sparse information is available on the mutual interaction of these two compounds in the brain. The potential intercourse of nitric oxide with brain neuropeptides needs to be substantiated by assessing its local production and gene expression of the synthesizing enzymes involved. The aim of the present study was to evaluate whether the gene expression of brain nitric oxide synthase (bNOS) is related to the sites of gene expression of different components of the rat brain renin angiotensin system (renin, angiotensin converting enzyme (ACE) or angiotensin receptors of AT1 and AT2 subtypes). The levels of corresponding mRNAs were measured and correlated in nine structures of adult rat brain (hippocampus, amygdala, septum, thalamus, hypothalamus, cortex, pons, medulla and cerebellum). As was expected, positive correlation was observed between renin and angiotensin-converting enzyme mRNAs. Moreover, a significant correlation was found between brain NO synthase and AT1 receptor mRNAs, but not with mRNA of the AT2 receptor, ACE and renin. Parallel distribution of mRNAs coding for bNOS and AT1 receptors in several rat brain structures suggests a possible interaction between brain angiotensin 11 and nitric oxide, which remains to be definitely demonstrated by other approaches.

• MeSH
• amygdala chemie   MeSH
• angiotensin konvertující enzym genetika   MeSH
• exprese genu * MeSH
• hipokampus chemie   MeSH
• hypothalamus chemie   MeSH
• krysa rodu Rattus MeSH
• medulla oblongata chemie   MeSH
• messenger RNA analýza   MeSH
• mozeček chemie   MeSH
• mozek - chemie MeSH
• mozek enzymologie   metabolismus   MeSH
• polymerázová řetězová reakce s reverzní transkripcí MeSH
• pons chemie   MeSH
• potkani Wistar MeSH
• receptor angiotensinu typ 1 MeSH
• receptor angiotensinu typ 2 MeSH
• receptory angiotensinu genetika   MeSH
• renin genetika   MeSH
• septum pellucidum chemie   MeSH
• synthasa oxidu dusnatého genetika   MeSH
• thalamus chemie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• angiotensin konvertující enzym MeSH
• messenger RNA MeSH
• receptor angiotensinu typ 1 MeSH
• receptor angiotensinu typ 2 MeSH
• receptory angiotensinu MeSH
• renin MeSH
• synthasa oxidu dusnatého MeSH

Dorsal lesions of the septum influenced the maternal behaviour of Wistar and Long-Evans females, as well as of their hybrids, in a different way. The phenomenon of infanticide appeared in Wistar females only, whereas mothering was not impaired in others. However, the mouse-killing activity was not enhanced in Wistar females displaying infanticide. On the contrary, they exhibited xenoparental behaviour. If these females had grown up in a species-typical environment, characterized by enriched social stimulation during their critical developmental period, no impairment of maternal behaviour following dorsal septal lesions occurred. The ablation of the whole septum caused a break-down of maternal behaviour with the appearance of infanticide in all females regardless of their stock origin and their individual life history. The specific role of the septum in the control of maternal behaviour is discussed.

• MeSH
• agrese fyziologie   MeSH
• chování zvířat fyziologie   MeSH
• inbrední kmeny potkanů MeSH
• krysa rodu Rattus MeSH
• mateřské chování fyziologie   MeSH
• myši MeSH
• novorozená zvířata MeSH
• potkani Wistar MeSH
• septum pellucidum fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• myši MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Inspired by current knowledge of the possible participation of monoamines in the origin of schizophrenia and by experimental experience with embryonic nerve tissue transplantations, the authors ventured implantation of a human embryo's nervous tissue into a schizophrenic's brain. Six cubic millimeters of the transplant were placed in the septal area of both hemispheres. The substantial improvement of the clinical picture and, particularly, distinct improvement of memory abilities in the patient can more likely be attributed to the effect of the transplant rather than to the simultaneous mechanical intervention in the target structure of the recipient's brain.

• MeSH
• dopamin fyziologie   MeSH
• dospělí MeSH
• lidé MeSH
• následné studie MeSH
• nervový systém transplantace   MeSH
• regenerace nervu * MeSH
• schizofrenie (psychologie) * MeSH
• schizofrenie chirurgie   MeSH
• septum pellucidum chirurgie   MeSH
• serotonin fyziologie   MeSH
• stereotaktické techniky MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• dopamin MeSH
• serotonin MeSH

The role of the septum in the regulation of blood pressure was studied in adult female and male laboratory (Alderley Park strain of Wistar) rats allowed a free choice between water and a 0.9% or 3% NaCl solution or simply given water. A lesion was formed in the dorsal septum and 30-66 days afterwards the mean arterial pressure was measured in the unanaesthetized animals' tail. In females the blood pressure was not affected either by the lesion itself, or by the lesion combined with a raised NaCl intake. In males, combination of the lesion with a raised salt intake was accompanied by elevation of the blood pressure, which attained values considered to be hypertensive (over 20 kPa). The increase occurred after 9 days' free choice between water and 3% NaCl solution preceded by 14 days' free choice between water and saline. At the same time, the computed NaCl concentration in the total fluids intake was higher in the control and septal females than in the control and septal males for both the salt regimens. Three days after changing from a free choice regimen to plain water intake, the blood pressure of septal males had fallen to normal values. After a protracted water regimen (43 days after discontinuing free choice), these animals had a lower blood pressure than sham-operated males after the same interval. The determinant variable in the effect of a dorsal septal lesion on the blood pressure in the presence of a hypertensogenic stimulus (NaCl) was the sex of the experimental animals.

• MeSH
• časové faktory MeSH
• chlorid sodný aplikace a dávkování   MeSH
• inbrední kmeny potkanů MeSH
• krevní tlak * MeSH
• krysa rodu Rattus MeSH
• pití MeSH
• pohlavní dimorfismus * MeSH
• septum pellucidum fyziologie   MeSH
• tělesná hmotnost MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• chlorid sodný MeSH

• MeSH
• corpus callosum * MeSH
• lidé MeSH
• nádory mozku diagnóza   MeSH
• nemoci thalamu diagnóza   MeSH
• retrospektivní studie MeSH
• septum pellucidum * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

The authors studied biopotentials in the region of the amygdala and the septum of rats fed on a standard, high protein or high fat diet. During the first 3-6 days after changing from the standard to the high protein or high fat diet, a decrease in the amplitude of electrical activity was found in both the regions in question. After 3 days on the high fat or the high protein diet, an increase was found in the frequency of electrical activity in the amygdala or the septum, according to the type of diet. A study of the amplitude of electrical activity showed that the electrical potential in the septum was always lower than in the amygdala. The frequency spectrum analysis showed a marked change in the superimposed frequency curve only in animals fed on the high fat diet.

• MeSH
• amygdala fyziologie   MeSH
• dietní proteiny metabolismus   MeSH
• dietní tuky metabolismus   MeSH
• elektrofyziologie MeSH
• Fourierova analýza MeSH
• krysa rodu Rattus MeSH
• septum pellucidum fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• dietní proteiny MeSH
• dietní tuky MeSH

• MeSH
• habituace (psychofyziologie) MeSH
• hipokampus metabolismus   MeSH
• hypertenze metabolismus   patofyziologie   psychologie   MeSH
• hypothalamus metabolismus   MeSH
• krevní tlak MeSH
• krysa rodu Rattus MeSH
• laktace MeSH
• mozek fyziologie   chirurgie   MeSH
• mozková kůra metabolismus   MeSH
• retence (psychologie) MeSH
• RNA metabolismus   MeSH
• septum pellucidum metabolismus   fyziologie   chirurgie   MeSH
• těhotenství MeSH
• tělesná hmotnost MeSH
• učení vyhýbat se * fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• RNA MeSH

Male laboratory rats prematurely weaned on the 15th day of life exhibited in adulthood an increase in seizure susceptibility in the septum, hypothalamus and hippocampus. The resting EEG of these animals exhibited characteristic changes demonstrated in the EEG spectrum power density by shifts in the power of individual frequencies. The administration of RNA to adult prematurely weaned animals affected in all structures under study the seizure susceptibility as well as the resting EEG, having caused in septum and hippocampus the return to values found in normally weaned rats. In hypothalamus the administration of RNA also changed the state given by the premature weaning but the return to normalcy was not complete.

• MeSH
• čelní lalok fyziologie   MeSH
• hipokampus fyziologie   MeSH
• hypotalamus střední fyziologie   MeSH
• krysa rodu Rattus MeSH
• mozek účinky léků   fyziologie   MeSH
• odstavení * MeSH
• RNA farmakologie   MeSH
• septum pellucidum fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• RNA MeSH