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MeSH: Visual Cortex-drug effects

14 záznamů v PubMed Filtry

Článek

Impact of dopamine and cognitive impairment on neural reactivity to facial emotion in Parkinson's disease

Dan, Rotem
Autor Dan, Rotem Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem, Israel; Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel
Růžička, Filip
Autor Růžička, Filip Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czechia; Department of Radiology, Na Homolce Hospital, Prague, Czechia
Bezdicek, Ondrej
Autor Bezdicek, Ondrej Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czechia
Roth, Jan
Autor Roth, Jan Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czechia
Růžička, Evžen
Autor Růžička, Evžen Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czechia
Vymazal, Josef
Autor Vymazal, Josef Department of Radiology, Na Homolce Hospital, Prague, Czechia
Goelman, Gadi
Autor Goelman, Gadi Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: gadig@hadassah.org.il
Jech, Robert
Autor Jech, Robert Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czechia; Department of Radiology, Na Homolce Hospital, Prague, Czechia

European neuropsychopharmacology. 2019 Nov ; 29 (11) : 1258-1272. [epub] 20191010

Eur Neuropsychopharmacol
ISSN 1873-7862 | 0924-977X
Zdroj

Emotional and cognitive impairments in Parkinson's disease (PD) are prevalent, hamper interpersonal relations and reduce quality of life. It is however unclear to what extent these domains interplay in PD-related deficits and how they are influenced by dopaminergic availability. This study examined the effect of cognitive impairment and dopaminergic medication on neural and behavioral mechanisms of facial emotion recognition in PD patients. PD patients on and off dopaminergic medication and matched healthy controls underwent an emotional face matching task during functional MRI. In addition, a comprehensive neuropsychological evaluation of cognitive function was conducted. Increased BOLD response to emotional faces was found in the visual cortex of PD patients relative to controls irrespective of cognitive function and medication status. Administration of dopaminergic medication in PD patients resulted in restored behavioral accuracy for emotional faces relative to controls and decreased retrosplenial cortex BOLD response to emotion relative to off-medication state. Furthermore, cognitive impairment in PD patients was associated with reduced behavioral accuracy for non-emotional stimuli and predicted BOLD response to emotion in the anterior and posterior cingulate cortices, depending on medication status. Findings of aberrant visual and retrosplenial BOLD response to emotion are suggested to stem from altered attentional and/or emotion-driven modulation from subcortical and higher cortical regions. Our results indicate neural disruptions and behavioral deficits in emotion processing in PD patients that are dependent on dopaminergic availability and independent of cognitive function. Our findings highlight the importance of dopaminergic treatment not only for the motor symptoms but also the emotional disturbances in PD.

Klíčová slova
Cognitive function, Dopamine, Emotion, Facial recognition, Parkinson's disease, fMRI,
MeSH
agonisté dopaminu farmakologie terapeutické užití MeSH
emoce účinky léků fyziologie MeSH
funkční zobrazování neurálních procesů MeSH
kognitivní dysfunkce komplikace farmakoterapie patofyziologie MeSH
lidé středního věku MeSH
lidé MeSH
magnetická rezonanční tomografie MeSH
neuropsychologické testy MeSH
neurozobrazování MeSH
Parkinsonova nemoc komplikace farmakoterapie patofyziologie MeSH
senioři nad 80 let MeSH
senioři MeSH
studie případů a kontrol MeSH
výraz obličeje * MeSH
zrakové korové centrum účinky léků fyziologie MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
klinické zkoušky kontrolované MeSH
práce podpořená grantem MeSH
Názvy látek
agonisté dopaminu MeSH

Článek

Retrieval of overtrained place navigation during occlusion of one eye and ipsi- or contralateral blockade of relevant brain centers in rats

Neurobiology of learning and memory. 1997 Jul ; 68 (1) : 60-7.

Neurobiol Learn Mem
ISSN 1074-7427
Zdroj

Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted cannulae aimed at the above structures were trained to find a target in the southwest quadrant of the pool. Retrieval was tested during occlusion of one eye alone or combined with ipsi- or contralateral blockade (1 microliter 4% lidocaine) of hippocampus, hippocampus and visual cortex, or hippocampus, visual cortex, and superior colliculus. The intact brain escape latencies (9.8 s) were only slightly prolonged by occlusion of one eye (to 12.6 s). Blockade of centers ipsi- or contralateral to the occluded eye increased escape latencies to 12.7 or 15.2 s for hippocampus, to 16.8 or 16.9 s for hippocampus and visual cortex, and to 23.6 or 17.4 s for hippocampus, visual cortex, and superior colliculus, respectively. Significant asymmetry appearing in the last case indicates that the superior colliculus plays an important role in mediation of the crossed visual input supporting place navigation. Residual goal-finding capability in rats with blockade of centers ipsilateral to the occluded eye is probably due to uncrossed visual projections to the intact hemisphere.

MeSH
bludiště - učení účinky léků fyziologie MeSH
colliculus superior účinky léků MeSH
hipokampus účinky léků MeSH
krysa rodu Rattus MeSH
lidokain farmakologie MeSH
oči - fyziologické jevy * MeSH
zrakové korové centrum účinky léků MeSH
zvířata MeSH
Check Tag
krysa rodu Rattus MeSH
mužské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Názvy látek
lidokain MeSH

Článek

Interhippocampal transfer of place navigation monocularly acquired by rats during unilateral functional ablation of the dorsal hippocampus and visual cortex with lidocaine

Neuroscience. 1994 Feb ; 58 (3) : 481-91.

ISSN 0306-4522
Zdroj

To study the neural mechanisms of interhippocampal transfer of lateralized place navigation engrams in rats, lidocaine was injected via chronically implanted cannulae to reversibly inactivate the hippocampal formation and the visual cortex on one side. The eye opposite the blocked side was occluded. Under these conditions, rats learned the location of an invisible platform in a water maze [mean escape latencies per four-trial block (t) = 5-6 s at the performance asymptote]. Monocular intact brain retrieval with the trained eye (t = 7) was better than with the untrained eye (t = 13). However, analysis of each retrieval trial indicated untrained eye performance was only poor on the first trial (t = 30). To test whether trans-commissural read-out alone or write-in (i.e. interhippocampal transfer) of the lateralized engram explains the above results, rats acquired a new platform location (t = 5). Two groups were then given a 30-s "free swim" (the platform was removed) with intact brain and either the trained or untrained eye occluded. A third group did not have this "transfer" trial. Retrieval was tested with the trained hippocampus and visual cortex blocked. With the trained eye occluded, retrieval in the rats that had the transfer trial (t = 11) was better than in those that did not (t = 25), but slightly worse than in rats tested with the untrained eye, hippocampus and visual cortex blocked (t = 7). Additionally, retrieval was similar, independent of whether the trained (t = 12) or untrained (t = 11) eye was open on the transfer swim. The 30-s swim alone did not induce comparable savings. We conclude that interhippocampal transfer of lateralized place learning is easily induced, is equal if the transfer is facultative or imperative, and involves both trans-commissural read-out and write-in processes.

MeSH
hipokampus anatomie a histologie účinky léků fyziologie MeSH
krysa rodu Rattus MeSH
lidokain farmakologie MeSH
operantní podmiňování účinky léků MeSH
orientace účinky léků MeSH
paměť fyziologie MeSH
vidění monokulární fyziologie MeSH
vnímání prostoru fyziologie MeSH
zrakové korové centrum anatomie a histologie účinky léků fyziologie MeSH
zvířata MeSH
Check Tag
krysa rodu Rattus MeSH
mužské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Názvy látek
lidokain MeSH

Článek

Protein kinase C in nucleus parabrachialis: effect of drugs inducing conditioned taste aversion

Krivanek, J
Autor Krivanek, J Institute of Physiology, Academy of Sciences, Prague, Czech Republic

Brain research. 1993 Dec 03 ; 629 (2) : 327-30.

Brain Res
ISSN 0006-8993
Zdroj

A method for the dissection of the nucleus parabrachialis (NPB) from the coronal sections of frozen rat brain is described. The protein kinase C (PKC) activity was determined in the cytosol and particulate fractions of the pooled samples of the nucleus. The effect of the i.p. administration of the conditioned taste aversion-inducing agents LiCl and CuSO4 on PKC in the NPB and visual cortex (VC) was tested. 1 h after the LiCl injection, the portion of the membrane-bound PKC was increased by 23% (P < 0.01) above the level found after the saline injection. CuSO4 produced a 19% increase. Since the PKC activity in the cytosol declined, it is likely that the translocation of the enzyme took place. No changes in the PKC distribution in the VC samples could be detected. The results support the idea that the PKC translocation is not directly induced by the tested substances but that it rather reflects changes in the activity of the visceral system.