OBJECTIVES: The Cow's Milk-related Symptom Score (CoMISS) is an awareness tool for evaluating cow's milk-related symptoms in otherwise healthy infants <1 year of age. This study assessed whether replacing the Bristol Stool Form Scale (BSFS) with the Brussels Infants and Toddlers Stool Scale (BITSS) in non-toilet-trained infants would modify the overall CoMiSS and change the clinical approach regarding potential cow's milk allergy. METHODS: Non-toilet-trained infants aged <13 months were assessed by CoMiSS using the 7 images from the BSFS (CoMiSS-BSFS) compared to the 4 images of stools from BITSS (CoMiSS-BITSS). The Wilcoxon signed-rank test and Pearson correlation coefficient were calculated. A post hoc analysis using identical tests was performed in subsets of CoMiSS-BSFS scores ≥10, ≥12, ≤5, and ≥6. RESULTS: Eight hundred forty-four pairwise scores were collected. Applying the Wilcoxon test over the complete dataset, the difference between CoMiSS-BSFS and CoMiSS-BITSS was statistically significant ( P < 0.001). However, there was no significant difference in the subsets with CoMiSS-BSFS ≥10, ≥12, and ≥6 ( P = 0.84, P = 0.48, and P = 0.81, respectively). The significant difference remained restricted to the group with CoMiSS-BSFS ≤5, considered at low risk for CM-related symptoms ( P < 0.001). CONCLUSION: Replacing BSFS with BITSS does not change the cutoff for awareness of possible CM-related symptoms and will not impact the use of CoMiSS in clinical practice. Changes in CoMiSS remained limited to the subgroup with a low risk for CM-related symptoms.
UNLABELLED: Few studies concerning the occurrence of cow's milk allergy with the use of double-blind, placebo controlled food challenge test in adolescents and adult patients suffering from atopic dermatitis exist. AIM: To evaluate the occurrence of cow's milk allergy in adolescents and adults suffering from atopic dermatitis. METHOD: Altogether 179 persons suffering from atopic dermatitis were included in the study: 51 men and 128 women entered the study with the average age of 26.2 (s.d. 9.5 years). Complete dermatological and allergological examinations were performed. RESULTS: The positive results in specific IgE and in skin prick tests were recorded in 12% of patients. According to the open exposure tests and double-blind, placebo controlled food challenge tests these patients are only sensitized to cow's milk without clinical symptoms of allergy. Double-blind, placebo controlled food challenge test confirmed food allergy to cow milk only in one patient (worsening of atopic dermatitis), the oral allergy syndrome was observed in another one patient, occurrence of this allergy was altogether 1.1%. CONCLUSION: Cow's milk allergy rarely plays a role in the worsening of atopic dermatitis in adolescent and adult patients.
- MeSH
- alergie na mléko komplikace diagnóza MeSH
- atopická dermatitida komplikace diagnóza patologie MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- imunoglobulin E krev MeSH
- imunologické testy * MeSH
- kožní testy MeSH
- lidé MeSH
- mladiství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- imunoglobulin E MeSH
The possible role of cow's milk intolerance in the aetiology of infantile colic was assessed in 19 infants in a town either by a health worker or family doctor. Modified standard preparations of cow's milk were compared for a period longer than three weeks with soya milk preparations in a double blind experiment. On soya mild the persistence of colic syndromes was significantly reduced within one week (p < 0.01) in 11 of 19 infants meeting the diagnostic criteria for cow's milk intolerance. Four children were the symptoms did not improve spontaneously nor after soya milk were given milk with hydrolyzed protein, in two the positive response was confirmed by exposure tests. Thus in 13 of 19 infants (88%) symptoms of infantile colic disappeared almost completely after the dietary change.
- MeSH
- alergie na mléko komplikace dietoterapie MeSH
- dospělí MeSH
- kojenec MeSH
- kolika dietoterapie etiologie MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- kojenec MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- klinické zkoušky kontrolované MeSH
- klinické zkoušky MeSH
