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MeSH: bursa Fabricii-chirurgie

12 záznamů v PubMed Filtry

Článek

The enigma of the lower gut-associated lymphoid tissue (GALT)

Butler, John E
Autor Butler, John E Institute of Microbiology AS CR, v.v.i., Doly 183, 54922 Novy Hradek, Czech Republic. marek.sinkora@worldonline.cz
Sinkora, Marek
Autor Sinkora, Marek

Journal of leukocyte biology. 2013 Aug ; 94 (2) : 259-70. [epub] 20130521

J Leukoc Biol
ISSN 1938-3673 | 0741-5400
Zdroj

Artiodactyls possess GALT that appears in fetal life and is located at the extreme end of the ileum. These IPP contain mostly B cells and involute early in postnatal life. Rabbits have a similarly located lymphoid organ, called the sacculus rotundus. Studies in sheep and rabbits have led to the concept that the lower hindgut GALT represents primary lymphoid tissue for B cells and is necessary for normal B cell development, analogous to the bursa of Fabricius. This review traces the history of the observations and theories that have led to the existing concept concerning the role of lower GALT. We then review recent data from piglets with resected IPP that challenges the concept that the IPP is primary B cell lymphoid tissue and that artiodactyls and rabbits are members of the GALT group in the same context as gallinaceous birds. Eliminating the IPP as the primary lymphoid tissue for B cells leads to the hypothesis that the IPP acts as first-responder mucosal lymphoid tissue.

Klíčová slova
B cell development, B lymphocytes, Peyer's patches, lymphogenesis, mucosal immunity,
MeSH
apoptóza MeSH
Artiodactyla imunologie MeSH
B-lymfocyty cytologie imunologie MeSH
buněčný rodokmen MeSH
bursa Fabricii cytologie imunologie chirurgie MeSH
druhová specificita MeSH
gnotobiologické modely MeSH
imunitní systém embryologie růst a vývoj MeSH
králíci imunologie MeSH
kur domácí imunologie MeSH
lidé MeSH
lymfatické uzliny cytologie imunologie MeSH
lymfoidní tkáň cytologie imunologie chirurgie MeSH
lymfopoéza MeSH
mezenterium imunologie MeSH
modely imunologické MeSH
Peyerovy pláty cytologie imunologie chirurgie MeSH
prasata imunologie MeSH
savci embryologie imunologie MeSH
střeva imunologie MeSH
střevní sliznice embryologie růst a vývoj imunologie MeSH
tvorba protilátek MeSH
zvířata MeSH
Check Tag
králíci imunologie MeSH
lidé MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek

The role of primary lymphoid organs of chickens in the elimination of 51Cr-labelled erythrocytes

Folia biologica. 1980 ; 26 (1) : 26-33.

Folia Biol (Praha)
ISSN 0015-5500
Zdroj

F1 chicken hybrids of the inbred lines CC and IC were given injections of erythrocytes from CB line chickens (differing at alloantigens of the major histocompatibility system B) or IA line chickens (differing at the A blood group system alloantigens). Injected erythrocytes were labelled with 51Cr and their gradual elimination from the recipient's circulation was checked. Surgical bursectomy was performed at the end of embryogenesis and thymectomy immediately after hatching. Bursectomy prolonged the survival of B- and A-incompatible erythrocytes. Thymectomy prolonged the survival of A-incompatible erythrocytes and had no effect on the elimination of erythrocytes possessing B antigens.

MeSH
ABO systém krevních skupin imunologie MeSH
bursa Fabricii imunologie chirurgie MeSH
cyklofosfamid farmakologie MeSH
erytrocyty imunologie MeSH
kur domácí krev imunologie MeSH
lymfoidní tkáň imunologie MeSH
radioizotopy chromu MeSH
thymektomie MeSH
thymus imunologie MeSH
tvorba protilátek MeSH
velikost orgánu MeSH
zvířata MeSH
Check Tag
zvířata MeSH
Publikační typ
časopisecké články MeSH
Názvy látek
ABO systém krevních skupin MeSH
cyklofosfamid MeSH
radioizotopy chromu MeSH

Článek

Attempts to characterize cellular mechanisms of immunologic tolerance to HSA in chickens

Folia biologica. 1977 ; 23 (5) : 336-45.

Folia Biol (Praha)
ISSN 0015-5500
Zdroj

Partial suppression of antibody formation in neonatally induced tolerance to HSA as observed during immunization at 6 weeks of age or at a later time, is caused mainly by a rapid escape from tolerance. The following findings support this view: 1. After immunization at 4 weeks of age with a larger dose of HSA, which elicits detectable circulating antibody formation in all control birds, anti-HSA antibodies cannot be demonstrated in a large majority of tolerant chickens. 2. Surgical bursectomy performed in tolerant birds on the day of hatching or 7 or 11 days after hatching increases considerably the degree of suppression of anti-HSA antibody formation and slows down the return of reactivity to HSA. These findings suggest that new immunocompetent cells originating in the bursa are responsible for escape from tolerance in this experimental system. The existence of suppressor cells in birds tolerant to HSA was not demonstrated by the transfers of spleen cell mixtures from immune and tolerant donors to young, irradiated recipients.