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MeSH: membránový protein 2 asociovaný s vezikuly-metabolismus

1 záznamů v PubMed Filtry

Článek

Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

Oliva Chávez, Adela S
Autor Oliva Chávez, Adela S ORCID Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA Department of Entomology, Texas A&M University, College Station, TX, USA
Wang, Xiaowei
Autor Wang, Xiaowei Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Marnin, Liron
Autor Marnin, Liron Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Archer, Nathan K
Autor Archer, Nathan K ORCID Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Hammond, Holly L
Autor Hammond, Holly L Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Carroll, Erin E McClure
Autor Carroll, Erin E McClure Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA Excerpta Medica, Doylestown, PA, USA
Shaw, Dana K
Autor Shaw, Dana K ORCID Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA
Tully, Brenden G
Autor Tully, Brenden G Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA
Buskirk, Amanda D
Autor Buskirk, Amanda D Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Process and Facilities, Division of Microbiology Assessment, Microbiology Assessment Branch III, U.S. Food and Drug Administration, Silver Spring, MD, USA
Ford, Shelby L
Autor Ford, Shelby L Centers for Disease Control and Prevention, Atlanta, GA, USA

Nature communications. 2021 Jun 17 ; 12 (1) : 3696. [epub] 20210617

Nat Commun
ISSN 2041-1723
Zdroj

Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.

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