BACKGROUND: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. OBJECTIVES: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed. METHODS: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control. RESULTS: The medians were: B-Pt 0.8 (range <0.6-5.2), B-Pd <5 (<5-9.3), B-Rh <0.4 (<0.4-3.6)ng/L and B-Mo 2.0 (0.2-16) and B-Sr 16.6 (3.5-49) μg/L. Two women with highly elevated B-Pt (242 and 60ng/L), previously cancer treated with cis-platinum, were not included in the data analysis. All elements varied geographically (2-3 times) (B-Pd P=0.05; all other elements P<0.001); variations within each area were generally 5-10 times. Traffic was not associated with increased concentrations. CONCLUSIONS: General population blood concentrations of Pt, Pd and Rh are within or below the single digit ng/L range, much lower than in most previous reports. This is probably due to improved analytical performance, allowing for more reliable information at ultra-trace levels. In general, Mo and Sr agreed with previously reported concentrations. All elements showed geographical and inter-individual variations, but no convincing relationships with self-reported traffic intensity were found. Pt from the antineoplastic drug cis-platinum is retained in the body for years.

• Klíčová slova
• Biomarkers, Biomonitoring, Catalytic converters, Cis-platinum, High-resolution ICP-MS, Human, Metals, Traffic, Women,
• MeSH
• lidé středního věku MeSH
• lidé MeSH
• molybden krev   MeSH
• monitorování životního prostředí * MeSH
• palladium krev   MeSH
• platina krev   MeSH
• rhodium krev   MeSH
• stroncium krev   MeSH
• těžké kovy krev   MeSH
• velkoměsta MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• velkoměsta MeSH
• Názvy látek
• molybden MeSH
• palladium MeSH
• platina MeSH
• rhodium MeSH
• stroncium MeSH
• těžké kovy MeSH

We studied the dynamics of Cu, Fe, Zn, Mo, As, Cd, Pb and Se in the serum of sheep during experimental copper (Cu) intoxication from emissions from a Cu factory. From the food and the dosed emission, the daily intake was 466.8 mg Cu, 1253.93 mg Fe, 11.67 mg Zn, 0.74 mg Mo, 34.75 mg As, 0.091 mg Cd, 2.13 mg Pb, and 2.57 mg Se/experimental ewe. After the onset of Cu intoxication the first ewe died on the 65th d and the last one on the 84th d of the experiment. Hypercupremia was observed from the 50th d after the beginning of emission administration. Significant changes were observed in serum Cu on the 50th, 70th and 77th d (P less than 0.01). Changes in the dynamics of the other elements were recorded at the end of the cumulative phase and during the hemolytic crisis by also determining Fe, Zn, Mo, As, Cd, Pb and Se in serum of the Cu-poisoned sheep.

• MeSH
• arsen krev   MeSH
• kadmium krev   MeSH
• látky znečišťující vzduch v pracovním prostředí krev   otrava   MeSH
• měď krev   otrava   MeSH
• minerály krev   MeSH
• molybden krev   MeSH
• olovo krev   MeSH
• ovce MeSH
• selen krev   MeSH
• železo krev   MeSH
• zinek krev   MeSH
• zvířata MeSH
• Check Tag
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• arsen MeSH
• kadmium MeSH
• látky znečišťující vzduch v pracovním prostředí MeSH
• měď MeSH
• minerály MeSH
• molybden MeSH
• olovo MeSH
• selen MeSH
• železo MeSH
• zinek MeSH

• MeSH
• alfa-makroglobuliny metabolismus   MeSH
• autoradiografie metody   MeSH
• časové faktory MeSH
• krysa rodu Rattus MeSH
• molybden aplikace a dávkování   krev   MeSH
• radionuklidy MeSH
• vazba proteinů MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• alfa-makroglobuliny MeSH
• molybden MeSH
• radionuklidy MeSH

• MeSH
• autoradiografie MeSH
• elektroforéza na papíru MeSH
• hematokrit MeSH
• kinetika MeSH
• krysa rodu Rattus MeSH
• metabolická clearance MeSH
• molybden krev   MeSH
• radionuklidy MeSH
• technecium MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• molybden MeSH
• radionuklidy MeSH
• technecium MeSH