• MeSH
• anemie z nedostatku železa farmakoterapie   MeSH
• aplikace orální MeSH
• lidé MeSH
• metaanalýza jako téma MeSH
• potravní doplňky * MeSH
• randomizované kontrolované studie jako téma MeSH
• sportovci * MeSH
• systematický přehled jako téma MeSH
• železo * aplikace a dávkování   krev   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• dopisy MeSH
• Názvy látek
• železo * MeSH

BACKGROUND: Data on the clinical significance of iron deficiency (ID) in patients with myocardial infarction (MI) are conflicting. This may be related to the use of various ID criteria. We aimed to compare the association of different ID criteria with all-cause mortality after MI. METHODS: Consecutive patients hospitalized for their first MI at a large tertiary heart center were included. We evaluated the association of different iron metabolism parameters measured on the first day after hospital admission with all-cause mortality. RESULTS: From the 1,156 patients included (aged 64±12 years, 25 % women), 194 (16.8 %) patients died during the median follow-up of 3.4 years. After multivariate adjustment, iron level ≤13 µmol/L (HR 1.67, 95 % CI 1.19-2.34) and the combination of iron level ≤12.8 µmol/L and soluble transferrin receptor (sTfR) ≥3 mg/L (HR 2.56, 95 % CI 1.64-3.99) termed as PragueID criteria were associated with increased mortality risk and had additional predictive value to the GRACE score. Compared to the model including iron level, the addition of sTfR improved risk stratification (net reclassification improvement 0.61, 95 % CI 0.52-0.69) by reclassifying patients into a higher-risk group. No association between ferritin level and mortality was found. 51 % of patients had low iron levels, and 58 % fulfilled the PragueID criteria. CONCLUSION: Iron deficiency is common among patients with the first MI. The PragueID criteria based on iron and soluble transferrin receptor levels provide the best prediction of mortality and should be evaluated in future interventional studies for the identification of patients potentially benefiting from intravenous iron therapy.

• Klíčová slova
• Criteria, Iron deficiency, Mortality, Myocardial infarction, Outcomes,
• MeSH
• anemie z nedostatku železa * mortalita   MeSH
• deficit železa MeSH
• ferritiny krev   MeSH
• hospitalizace MeSH
• infarkt myokardu * mortalita   MeSH
• lidé středního věku MeSH
• lidé MeSH
• multivariační analýza MeSH
• příčina smrti MeSH
• proporcionální rizikové modely MeSH
• receptory transferinu krev   MeSH
• rizikové faktory MeSH
• senioři MeSH
• železo * krev   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• ferritiny MeSH
• receptory transferinu MeSH
• železo * MeSH

Exercise-induced inflammation can influence iron metabolism. Conversely, the effects of vitamin D3, which possesses anti-inflammatory properties, on ultramarathon-induced heart damage and changes in iron metabolism have not been investigated. Thirty-five healthy long-distance semi-amateur runners were divided into two groups: one group received 150,000 IU of vitamin D3 24 h prior to a race (n = 16), while the other group received a placebo (n = 19). Serum iron, hepcidin (HPC), ferritin (FER), erythroferrone (ERFE), erythropoietin (EPO), neopterin (NPT), and cardiac troponin T (cTnT) levels were assessed. A considerable effect of ultramarathon running on all examined biochemical markers was observed, with a significant rise in serum levels of ERFE, EPO, HPC, NPT, and cTnT detected immediately post-race, irrespective of the group factor. Vitamin D3 supplementation showed a notable interaction with the UM, specifically in EPO and cTnT, with no other additional changes in the other analysed markers. In addition to the correlation between baseline FER and post-run ERFE, HPC was modified by vitamin D. The ultramarathon significantly influenced the EPO/ERFE/HPC axis; however, a single substantial dose of vitamin D3 had an effect only on EPO, which was associated with the lower heart damage marker cTnT after the run.

• Klíčová slova
• erythroferrone, erythropoietin, ferritin, iron, ultramarathon, vitamin D,
• MeSH
• biologické markery * krev   MeSH
• cholekalciferol * aplikace a dávkování   MeSH
• dospělí MeSH
• dvojitá slepá metoda MeSH
• erythropoetin krev   aplikace a dávkování   MeSH
• hepcidiny krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• maratonský běh * fyziologie   MeSH
• nemoci srdce prevence a kontrola   etiologie   MeSH
• potravní doplňky * MeSH
• troponin T krev   MeSH
• železo * krev   aplikace a dávkování   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• biologické markery * MeSH
• cholekalciferol * MeSH
• erythropoetin MeSH
• hepcidiny MeSH
• troponin T MeSH
• železo * MeSH

The clinical presentation of iron deficiency can be very heterogeneous, including various oral and other mucosal problems. Here, in this case, we report the patient with burning mouth and dysphagia symptoms where iron deficiency was found to be the underlying cause after several months of investigations. This clinical syndrome is called Plummer-Vinson syndrome. It is sporadic with an incidence less than 0.1% of patients suffering from iron deficiency anemia.

• Klíčová slova
• anemia, burning mouth, dysphagia, iron deficiency,
• MeSH
• anemie z nedostatku železa diagnóza   etiologie   MeSH
• deficit železa MeSH
• diferenciální diagnóza MeSH
• ezofágus * diagnostické zobrazování   patologie   MeSH
• lidé MeSH
• management péče o pacienta metody   MeSH
• nemoci úst * diagnóza   etiologie   terapie   MeSH
• Plummerův-Vinsonův syndrom * diagnóza   patofyziologie   MeSH
• poruchy polykání * diagnóza   etiologie   MeSH
• senioři MeSH
• stopové prvky terapeutické užití   MeSH
• výsledek terapie MeSH
• železo * krev   terapeutické užití   MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• stopové prvky MeSH
• železo * MeSH

INTRODUCTION: Oral manifestations of deficiency of iron, vitamin B12 and folic acid are thought to be common. Prevalence of these deficiencies among patients with compatible symptoms is not well known. The goal of this study was to summarize evidence from a dental practice of iron, vitamin B12 and folic acid deficiency in patients presenting with compatible oral manifestations. METHODS: 250 patients who presented with burning mouth syndrome, angular cheilitis, recurrent aphthous stomatitis, papillar atrophy of the tongue dorsum or mucosal erythema were identified. Patients underwent clinical examination, and the blood samples were taken. RESULTS: 250 patients (208 females; 42 males, mean age 44.1 years) with at least one corresponding symptom or sign were identified. The nutritional deficiency of one or more nutrients was found in 119 patients (47.6%). Seven times more females than males were noted to have one type of deficiency (104 females, 15 males). Iron deficiency as defined was diagnosed in 62 patients (24.8%), vitamin B12 or folic acid deficiency in 44 patients (17.6%) and both deficiencies (iron + vitamin B12/folic acid) in 13 patients (5.2%). The only predictive factor was gender and only for iron deficiency. The presence of more than one deficiency was noted in 10 patients (4.9%). CONCLUSION: The most commonly observed deficiency in dental practice over the course of 11 years was an iron deficiency in the female population. Age, diet and reported co-morbidities did not show statistically significant predictable value in recognizing these deficiencies.

• Klíčová slova
• anemia, folic acid, iron deficiency, oral manifestations, vitamin B12,
• MeSH
• deficit železa MeSH
• dospělí MeSH
• kyselina listová krev   MeSH
• lidé MeSH
• nedostatek kyseliny listové * diagnóza   epidemiologie   etiologie   MeSH
• nedostatek vitaminu B12 * diagnóza   epidemiologie   etiologie   MeSH
• nemoci úst * klasifikace   diagnóza   epidemiologie   etiologie   MeSH
• podvýživa * krev   diagnóza   epidemiologie   patofyziologie   MeSH
• sexuální faktory MeSH
• vitamin B 12 krev   MeSH
• vzorové postupy ve stomatologii statistika a číselné údaje   MeSH
• železo * krev   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Názvy látek
• kyselina listová MeSH
• vitamin B 12 MeSH
• železo * MeSH

BACKGROUND: Neurodegeneration with brain iron accumulation constitutes a group of rare progressive movement disorders sharing intellectual disability and neuroimaging findings as common denominators. Beta-propeller protein-associated neurodegeneration (BPAN) represents approximately 7% of the cases, and its first signs are typically epilepsy and developmental delay. We aimed to describe in detail the phenotype of BPAN with a special focus on iron metabolism. MATERIAL AND METHODS: We present a cohort of paediatric patients with pathogenic variants of WD-Repeat Domain 45 gene (WDR45). The diagnosis was established by targeted panel sequencing of genes associated with epileptic encephalopathies (n = 9) or by Sanger sequencing of WDR45 (n = 1). Data on clinical characteristics, molecular-genetic findings and other performed investigations were gathered from all participating centres. Markers of iron metabolism were analysed in 6 patients. RESULTS: Ten children (3 males, 7 females, median age 8.4 years) from five centres (Prague, Berlin, Vogtareuth, Tubingen and Cologne) were enrolled in the study. All patients manifested first symptoms (e.g. epilepsy, developmental delay) between 2 and 31 months (median 16 months). Seven patients were seizure-free (6 on antiepileptic medication, one drug-free) at the time of data collection. Neurological findings were non-specific with deep tendon hyperreflexia (n = 4) and orofacial dystonia (n = 3) being the most common. Soluble transferrin receptor/log ferritin ratio was elevated in 5/6 examined subjects; other parameters of iron metabolism were normal. CONCLUSION: Severity of epilepsy often gradually decreases in BPAN patients. Elevation of soluble transferrin receptor/log ferritin ratio could be another biochemical marker of the disease and should be explored by further studies.

• Klíčová slova
• Beta-propeller protein-associated neurodegeneration, Neurodegeneration with brain iron accumulation WDR45, BPAN, Targeted gene panel sequencing,
• MeSH
• biologické markery krev   MeSH
• dítě MeSH
• epilepsie krev   genetika   metabolismus   MeSH
• fenotyp MeSH
• lidé MeSH
• mentální retardace krev   genetika   metabolismus   MeSH
• neurodegenerativní nemoci krev   genetika   metabolismus   MeSH
• pohybové poruchy krev   genetika   metabolismus   MeSH
• poruchy metabolismu železa krev   genetika   metabolismus   MeSH
• transportní proteiny genetika   MeSH
• železo krev   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• biologické markery MeSH
• transportní proteiny MeSH
• WDR45 protein, human MeSH Prohlížeč
• železo MeSH

Haematological parameters, plasma iron concentration, and bodyweight were monitored in Melanoma-bearing Libechov Minipigs (MeLiM) from 5 to 18 weeks old. Animals with melanoma progression (P group) and spontaneous regression (SR group) were compared. The P group showed the lowest median values of red blood cell counts (RBC), haematocrit (HCT), haemoglobin concentration (HGB), and bodyweight, whereas the control white (tumour-free) pigs (C group) revealed the highest mean values of these parameters. The mean values of pigs with SR fell between the P and C groups. In addition, a stable concentration of plasma iron was found in the C group, while iron deficiency that increases with age was observed in the MeLiM groups. These results indicate that MeLiM are affected by cancer-related microcytic hypochromic anaemia. The lowest values of HGB, RBC, and HCT, together with the highest number of platelets (PLT) in the P group correspond to melanoma progression. Higher values of these parameters and lower PLT in the MeLiM pigs with SR reflected health improvement due to the destruction of melanoma cells during spontaneous regression. Monitoring of these haematological parameters can help distinguish MeLiM piglets with progression and spontaneous regression of melanoma in the early stages of postnatal development. The findings of this study correspond to findings in human patients in which cancer-related anaemia, thrombocytosis, and iron deficiency are often diagnosed.

• Klíčová slova
• Cancer progression and spontaneous regression, Haematological parameters, Pig melanoma, Plasma iron,
• MeSH
• hematologické testy veterinární   MeSH
• melanom krev   patofyziologie   veterinární   MeSH
• miniaturní prasata MeSH
• nádory kůže krev   patofyziologie   veterinární   MeSH
• nemoci prasat krev   patofyziologie   MeSH
• prasata MeSH
• progrese nemoci MeSH
• spontánní regrese nádoru MeSH
• tělesná hmotnost MeSH
• železo aplikace a dávkování   krev   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• železo MeSH

OBJECTIVES: Previous research has shown that nutrition can influence cognitive abilities in older adults. We examined whether nutritional factors or inflammatory biomarkers moderate the age-cognition association. METHOD: Analyses included 1,308 participants (age ≥60) from the National Health and Nutrition Examination Survey III. Macronutrients (% of calories from fat, protein, and carbohydrates), micronutrients/amino acids (blood serum values: Vitamins B12, C, D, E, folate, iron, homocysteine, and β-carotene), and inflammatory biomarkers (serum C-reactive protein, plasma fibrinogen, and serum ferritin) were examined as moderators with cognition. Cognition was measured by six tasks: immediate and delayed story recall, immediate and delayed word memory, digit subtraction, and questions about place/orientation. RESULTS: Higher values of serum folate were significantly associated with better cognitive scores. Specifically, the interaction between age-cognition and folate indicated the associations of higher age and lower global cognition and lower immediate story recall were weaker in those with higher folate values (p's < .05). A significant interaction between age and plasma fibrinogen indicated that the association between age and worse digit subtraction was stronger with values >3.1 g/L. DISCUSSION: Folate and fibrinogen were significant moderators between age and cognition. Further research into the relationship between nutrition, inflammation, and cognitive aging is needed.

• MeSH
• beta-karoten krev   MeSH
• biologické markery krev   MeSH
• C-reaktivní protein analýza   MeSH
• dieta statistika a číselné údaje   MeSH
• ferritiny krev   MeSH
• fibrinogen analýza   MeSH
• homocystein krev   MeSH
• kognice * MeSH
• kognitivní dysfunkce krev   etiologie   MeSH
• kyselina listová krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• neuropsychologické testy MeSH
• nutriční stav * MeSH
• senioři MeSH
• věkové faktory MeSH
• vitaminy krev   MeSH
• výživa - přehledy MeSH
• zánět krev   komplikace   MeSH
• železo krev   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• beta-karoten MeSH
• biologické markery MeSH
• C-reaktivní protein MeSH
• ferritiny MeSH
• fibrinogen MeSH
• homocystein MeSH
• kyselina listová MeSH
• vitaminy MeSH
• železo MeSH

AIM: Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. METHODS: Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross-sectional study. We analysed levels of serum hepcidin, C-reactive protein, iron, ferritin, soluble transferrin receptors, blood count and faecal calprotectin in all subjects. Serum hepcidin levels were measured by reverse-phase liquid chromatography. The Paediatric Crohn's Disease Activity Index was used to evaluate CD in children, and Paediatric Ulcerative Colitis Activity Index was used for the assessment of UC disease activity. RESULTS: Subjects with CD (n = 53) had significantly higher serum hepcidin levels compared with subjects with UC (n = 23) - 22.6 ng/mL (range 8.5-65.0) versus 6.5 ng/mL (range 2.4-25.8) (P < 0.05). Hepcidin was independently associated with ferritin levels in all IBD patients (P < 0.05). Moreover, there was a significant positive correlation between hepcidin and platelet count (P < 0.05) in children with CD and a negative correlation between hepcidin and faecal calprotectin (P < 0.05) in children with UC. CONCLUSION: Different hepcidin levels between children with newly diagnosed CD and UC suggest the distinct contribution of iron deficiency and/or systemic inflammation to anaemia and may help clinicians choose the best anti-anaemic treatment.

• Klíčová slova
• Crohn's disease, anaemia, children, hepcidin, inflammatory bowel disease, ulcerative colitis,
• MeSH
• antiinfekční látky krev   MeSH
• C-reaktivní protein analýza   MeSH
• dítě MeSH
• feces chemie   MeSH
• ferritiny krev   MeSH
• hepcidiny krev   MeSH
• idiopatické střevní záněty diagnóza   MeSH
• leukocytární L1-antigenní komplex krev   MeSH
• lidé MeSH
• mladiství MeSH
• průřezové studie MeSH
• železo krev   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antiinfekční látky MeSH
• C-reaktivní protein MeSH
• ferritiny MeSH
• hepcidiny MeSH
• leukocytární L1-antigenní komplex MeSH
• železo MeSH

BACKGROUND: Heart failure (HF) is often associated with iron deficiency (ID). Skeletal muscle abnormalities are common in HF, but the potential role of ID in this phenomenon is unclear. In addition to hemopoiesis, iron is essential for muscle bioenergetics. We examined whether energetic abnormalities in skeletal muscle in HF are affected by ID and if they are responsive to intravenous iron. METHODS AND RESULTS: Forty-four chronic HF subjects and 25 similar healthy volunteers underwent 31P magnetic resonance spectroscopy of calf muscle at rest and during exercise (plantar flexions). Results were compared between HF subjects with or without ID. In 13 ID-HF subjects, examinations were repeated 1 month after intravenous ferric carboxymaltose administration (1000 mg). As compared with controls, HF subjects displayed lower resting high-energy phosphate content, lower exercise pH, and slower postexercise PCr recovery. Compared with non-ID HF, ID-HF subjects had lower muscle strength, larger PCr depletion, and more profound intracellular acidosis with exercise, consistent with an earlier metabolic shift to anaerobic glycolysis. The exercise-induced PCr drop strongly correlated with pH change in HF group ( r=-0.71, P<0.001) but not in controls ( r=0.13, P=0.61, interaction: P<0.0001). Short-term iron administration corrected the iron deficit but had no effect on muscle bioenergetics assessed 1 month later. CONCLUSIONS: HF patients display skeletal muscle myopathy that is more severe in those with iron deficiency. The presence of ID is associated with greater acidosis with exercise, which may explain early muscle fatigue. Further study is warranted to identify the strategy to restore iron content in skeletal muscle.

• Klíčová slova
• heart failure, iron, magnetic resonance spectroscopy, metabolism, muscles,
• MeSH
• acidóza metabolismus   patofyziologie   MeSH
• bérec MeSH
• biologické markery krev   MeSH
• časové faktory MeSH
• deficit železa * MeSH
• dospělí MeSH
• energetický metabolismus * účinky léků   MeSH
• intravenózní podání MeSH
• isometrická kontrakce * MeSH
• izotopy fosforu * MeSH
• kosterní svaly účinky léků   metabolismus   patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• magnetická rezonanční spektroskopie metody   MeSH
• maltosa aplikace a dávkování   analogy a deriváty   MeSH
• prediktivní hodnota testů MeSH
• senioři MeSH
• srdeční selhání diagnóza   farmakoterapie   metabolismus   patofyziologie   MeSH
• studie případů a kontrol MeSH
• výsledek terapie MeSH
• zátěžový test * MeSH
• železité sloučeniny aplikace a dávkování   MeSH
• železo krev   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH
• Názvy látek
• biologické markery MeSH
• ferric carboxymaltose MeSH Prohlížeč
• izotopy fosforu * MeSH
• maltosa MeSH
• železité sloučeniny MeSH
• železo MeSH