Ticks and tick-borne pathogens (TBPs) pose a considerable threat to human and animal health in Mongolia; a large and sparsely inhabited country whose economy is largely dependent on animal production. Intensive contact between herdsmen and their livestock, together with the use of pastures without fencing, allows contact between wildlife, domestic animals and humans, thus creating ideal conditions for epizoonoses and zoonoses. Consequently, ticks and TBPs cause significant medical, veterinary, and economical concern. This review summarizes the current state of knowledge about this zoonotic problem in Mongolia, focusing on tick species from the genera Ixodes, Haemaphysalis, Dermacentor, Hyalomma, and Rhipicephalus, which are associated with particular vegetation zones of the country. The most important tick species of medical and veterinary concern are Ixodes persulcatus and Dermacentor nuttalli, which are found in northern boreal forests and central steppes, respectively. These tick species transmit a wide variety of TBPs, including tick-borne encephalitis virus, Borrelia, Anaplasma, and Rickettsia bacteria, and Babesia parasites infecting rodents, wild ungulates, livestock, and humans. Despite basic characteristics of the biology of ticks and TBPs in Mongolia being known, further research is needed to gain more precise and quantitative data on what tick species and TBPs are currently present within Mongolia, and their effects on human health and animal production.
- Klíčová slova
- Anaplasma, Babesia, Borrelia, Rickettsia, Tick, Tick-borne encephalitis virus,
- MeSH
- Ixodidae fyziologie MeSH
- nemoci přenášené klíšťaty přenos virologie MeSH
- rozšíření zvířat * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Geografické názvy
- Mongolsko MeSH
Following the identification of severe fever with thrombocytopenia syndrome and Heartland viruses, the interest on tick-borne phleboviruses has increased rapidly. Uukuniemi virus has been proposed as a model for tick-borne phleboviruses. However, the number of available sequences is limited. In the current study we performed whole-genome sequencing on two Uukuniemi viral strains isolated in 2000 and 2004 from Ixodes ricinus ticks in the Czech Republic. Both strains cluster together with Potepli63 strain isolated in the country in 1963. Although the Czech strains were isolated many years apart, a high identity was seen at the nucleotide and amino acid levels, suggesting that UUKV has a relatively stable genome.
- Klíčová slova
- Czech Republic, Ixodes ricinus, Phlebovirus, Uukuniemi virus,
- MeSH
- genom virový MeSH
- infekce viry z čeledi Bunyaviridae epidemiologie MeSH
- klíště virologie MeSH
- nemoci přenášené klíšťaty epidemiologie virologie MeSH
- sekvenování celého genomu MeSH
- virus Uukuniemi genetika izolace a purifikace MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
Ticks, as vectors of several notorious zoonotic pathogens, represent an important and increasing threat for human and animal health in Europe. Recent applications of new technology revealed the complexity of the tick microbiome, which may affect its vectorial capacity. Appreciation of these complex systems is expanding our understanding of tick-borne pathogens, leading us to evolve a more integrated view that embraces the 'pathobiome'; the pathogenic agent integrated within its abiotic and biotic environments. In this review, we will explore how this new vision will revolutionize our understanding of tick-borne diseases. We will discuss the implications in terms of future research approaches that will enable us to efficiently prevent and control the threat posed by ticks.
- Klíčová slova
- Ixodes ricinus, co-infections, emerging diseases, new paradigm, next-generation sequencing, pathobiome, unknown pathogens, vector competence, zoonoses,
- MeSH
- klíšťata mikrobiologie virologie MeSH
- lidé MeSH
- mikrobiota * MeSH
- nemoci přenášené klíšťaty epidemiologie mikrobiologie přenos virologie MeSH
- zoonózy epidemiologie mikrobiologie přenos virologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Geografické názvy
- Evropa epidemiologie MeSH
The aim of this review is to present briefly background information on 27 tick-borne viruses ("tiboviruses") that have been detected in Europe, viz flaviviruses tick-borne encephalitis (TBEV), louping-ill (LIV), Tyuleniy (TYUV), and Meaban (MEAV); orthobunyaviruses Bahig (BAHV) and Matruh (MTRV); phleboviruses Grand Arbaud (GAV), Ponteves (PTVV), Uukuniemi (UUKV), Zaliv Terpeniya (ZTV), and St. Abb's Head (SAHV); nairoviruses Soldado (SOLV), Puffin Island (PIV), Avalon (AVAV), Clo Mor (CMV), Crimean-Congo hemorrhagic fever (CCHFV); bunyavirus Bhanja (BHAV); coltivirus Eyach (EYAV); orbiviruses Tribec (TRBV), Okhotskiy (OKHV), Cape Wrath (CWV), Mykines (MYKV), Tindholmur (TDMV), and Bauline (BAUV); two thogotoviruses (Thogoto THOV, Dhori DHOV); and one asfivirus (African swine fever virus ASFV). Emphasis is laid on the taxonomic status of these viruses, range of their ixodid or argasid vectors and vertebrate hosts, pathogenicity for vertebrates including humans, and relevance to public health. In general, three groups of tibovirus diseases can be recognized according to main clinical symptoms produced: (i) febrile illness-usually with a rapid onset, fever, sweating, headache, nausea, weakness, myalgia, arthralgia, sometimes polyarthritis and rash; (ii) the CNS affection-meningitis, meningoencephalitis or encephalomyelitis with pareses, paralysis and other sequelae; (iii) hemorrhagic disease. Several "European" tiboviruses cause very serious human (TBEV, CCHFV) or animal (LIV, ASFV) diseases. Other arboviruses play definite role in human or animal pathology though the disease is usually either less serious or infrequently reported (TYUV, BHAV, AVAV, EYAV, TRBV, DHOV, THOV). The other European arboviruses are "orphans" without a proven medical or veterinary significance (BAHV, MTRV, MEAV, GAV, PTVV, ZTV, SAHV, UUKV, SOLV, PIV, AVAV, CMV, OKHV, CWV, MYKV, TDMV, BAUV). However, certain arbovirus diseases of free-living vertebrates (but also those of domestic animals and even man) may often pass unnoticed or misdiagnosed and eventually, they might potentially appear as emerging diseases. Active search for new tiboviruses or for new, pathogenic variants of the known tiboviruses in Europe should therefore continue.
- MeSH
- infekce přenášené vektorem MeSH
- klíšťata virologie MeSH
- lidé MeSH
- nemoci přenášené klíšťaty virologie MeSH
- virové nemoci virologie MeSH
- viry klasifikace izolace a purifikace patogenita MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Geografické názvy
- Evropa MeSH
