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MeSH: respirační alergie-farmakoterapie

8 záznamů v PubMed Filtry

Článek

Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma

Manni, Michelle L
Autor Manni, Michelle L Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA
Heinrich, Victoria A
Autor Heinrich, Victoria A Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA
Buchan, Gregory J
Autor Buchan, Gregory J Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA
O'Brien, James P
Autor O'Brien, James P Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA
Uvalle, Crystal
Autor Uvalle, Crystal Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA
Cechova, Veronika
Autor Cechova, Veronika Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA Department of Cell Biology and Radiobiology, Institute of Biophysics, Czech Academy of Sciences, 61265, Brno, Czech Republic
Koudelka, Adolf
Autor Koudelka, Adolf Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA Department of Cell Biology and Radiobiology, Institute of Biophysics, Czech Academy of Sciences, 61265, Brno, Czech Republic
Ukani, Dharti
Autor Ukani, Dharti Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA
Rawas-Qalaji, Mohamad
Autor Rawas-Qalaji, Mohamad Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, E1345, Pittsburgh, PA, 15261, USA
Oury, Tim D
Autor Oury, Tim D Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA

Scientific reports. 2021 Sep 07 ; 11 (1) : 17788. [epub] 20210907

Sci Rep
ISSN 2045-2322
Zdroj

Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung pathophysiology. We also test the therapeutic potential of nitro-oleic acid (NO2-OA), a regulator of metabolic and inflammatory signaling pathways, to mitigate allergen and obesity-induced lung function decline in a murine model of asthma. Bile acids were measured in the plasma of healthy subjects and individuals with asthma and serum and lung tissue of mice with and without allergic airway disease (AAD). Lung function, indices of inflammation and hepatic bile acid enzyme expression were measured in obese mice with house dust mite-induced AAD treated with vehicle or NO2-OA. Serum levels of glycocholic acid and glycoursodeoxycholic acid clinically correlate with body mass index and airway hyperreactivity whereas murine levels of β-muricholic acid and tauro-β-muricholic acid were significantly increased and positively correlated with impaired lung function in obese mice with AAD. NO2-OA reduced murine bile acid levels by modulating hepatic expression of bile acid synthesis enzymes, with a concomitant reduction in small airway resistance and tissue elastance. Bile acids correlate to body mass index and lung function decline and the signaling actions of nitroalkenes can limit AAD by modulating bile acid metabolism, revealing a potential pharmacologic approach to improving the current standard of care.

Článek

Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance

The Journal of pharmacology and experimental therapeutics. 2020 Jun ; 373 (3) : 476-487. [epub] 20200409

J Pharmacol Exp Ther
ISSN 1521-0103 | 0022-3565
Zdroj

Zona pellucida binding protein 2 (Zpbp2) and ORMDL sphingolipid biosynthesis regulator 3 (Ormdl3), mapped downstream of Zpbp2, were identified as two genes associated with airway hyper-responsiveness (AHR). Ormdl3 gene product has been shown to regulate the biosynthesis of ceramides. Allergic asthma was shown to be associated with an imbalance between very-long-chain ceramides (VLCCs) and long-chain ceramides (LCCs). We hypothesized that Fenretinide can prevent the allergic asthma-induced augmentation of Ormdl3 gene expression, normalize aberrant levels of VLCCs and LCCs, and treat allergic asthma symptoms. We induced allergic asthma by house dust mite (HDM) in A/J WT mice and Zpbp2 KO mice expressing lower levels of Ormdl3 mRNA than WT. We investigated the effect of a novel formulation of Fenretinide, LAU-7b, on the AHR, inflammatory cell infiltration, mucus production, IgE levels, and ceramide levels. Although lower Ormdl3 expression, which was observed in Zpbp2 KO mice, was associated with lower AHR, allergic Zpbp2 KO mice were not protected from inflammatory cell infiltration, mucus accumulation, or aberrant levels of VLCCs and LCCs induced by HDM. LAU-7b treatment protects both the Zpbp2 KO and WT mice. The treatment significantly lowers the gene expression of Ormdl3, normalizes the VLCCs and LCCs, and corrects all the other phenotypes associated with allergic asthma after HDM challenge, except the elevated levels of IgE. LAU-7b treatment prevents the augmentation of Ormdl3 expression and ceramide imbalance induced by HDM challenge and protects both WT and Zpbp2 KO mice against allergic asthma symptoms. SIGNIFICANCE STATEMENT: Compared with A/J WT mice, KO mice with Zpbp2 gene deletion have lower AHR and lower levels of Ormdl3 expression. The novel oral clinical formulation of Fenretinide (LAU-7b) effectively lowers the AHR and protects against inflammatory cell infiltration and mucus accumulation induced by house dust mite in both Zpbp2 KO and WT A/J mice. LAU-7b prevents Ormdl3 overexpression in WT allergic mice and corrects the aberrant levels of very-long-chain and long-chain ceramides in both WT and Zpbp2 KO allergic mice.

MeSH
bronchiální astma farmakoterapie metabolismus MeSH
ceramidy metabolismus MeSH
down regulace účinky léků MeSH
exprese genu účinky léků MeSH
fenretinid farmakologie MeSH
membránové proteiny metabolismus MeSH
modely nemocí na zvířatech MeSH
myši knockoutované MeSH
myši MeSH
respirační alergie farmakoterapie metabolismus MeSH
zánět metabolismus MeSH
zvířata MeSH
Check Tag
mužské pohlaví MeSH
myši MeSH
ženské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Názvy látek
ceramidy MeSH
fenretinid MeSH
membránové proteiny MeSH
ORMDL3 protein, mouse MeSH Prohlížeč

Článek

Aktivácia poskodenej nosovej mukociliárnej funkcie u detí
[Activation of damaged nasal mucociliary function in children]

Ceskoslovenska otolaryngologie. 1989 Jan ; 38 (1) : 45-7.

Cesk Otolaryngol
ISSN 0009-0603
Zdroj

In 25 children with damaged mucociliary function of the nasal mucosa the authors used local ATP treatment. It was found that ATP solution applied to the nasal mucosa improves mucociliary function and reduces the transport time to normal; in acute, relapsing and allergic rhinosinusitis, in Kartagener's syndrome it improves partially the function of cilia, while transport remains prolonged. It seems that local application of ATP in drops may have a favourable effect on rhinosinusitis and prevent relapses.

MeSH
adenosintrifosfát terapeutické užití MeSH
akutní nemoc MeSH
dítě MeSH
Kartagenerův syndrom farmakoterapie patofyziologie MeSH
lidé MeSH
mukociliární clearance účinky léků MeSH
respirační alergie farmakoterapie MeSH
sinusitida farmakoterapie patofyziologie MeSH
Check Tag
dítě MeSH
lidé MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
Názvy látek
adenosintrifosfát MeSH

Článek

Dlouhodobá lécba ketotifenem a hladiny růstového hormonu u dĕtí
[Long-term treatment with ketotifen and levels of growth hormone in children]

Ceskoslovenska pediatrie. 1984 Dec ; 39 (12) : 718-20.

Cesk Pediatr
ISSN 0069-2328
Zdroj

MeSH
bronchiální astma krev farmakoterapie MeSH
časové faktory MeSH
ketotifen terapeutické užití MeSH
krevní glukóza analýza MeSH
lidé MeSH
předškolní dítě MeSH
respirační alergie krev farmakoterapie MeSH
růstový hormon krev MeSH
Check Tag
lidé MeSH
mužské pohlaví MeSH
předškolní dítě MeSH
ženské pohlaví MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
Názvy látek
ketotifen MeSH
krevní glukóza MeSH
růstový hormon MeSH

Článek

Contemporary problems of epidemiology and treatment of respiratory allergies and bronchial asthma

Zavázal, V
Autor Zavázal, V

Czechoslovak medicine. 1980 ; 3 (4) : 255-62.

Czech Med
ISSN 0139-9179
Zdroj

A general scheme of long-term treatment of bronchial asthma and the author's own results of immunotherapy, prophylaxis and other experiences in controlling the disease are presented. The necessity of permanent hyposensitization and prophylaxis by Zaditen and Na-cromoglycate has been emphasized. The rising incidence of respiratory allergies makes it necessary to find new ways of collaboration of allergists and other specialists.