BACKGROUND: The aim of this study was comparison the effectiveness of sequential and standard quadruple therapy on eradication of H. pylori infection. METHODS: This clinical trial study was conducted on 160 patients with dyspepsia or gastroduodenal ulcer. Patients were randomly divided into two groups. Group A (standard regimen) received omeprazole, amoxicillin, clarithromycin and bismuth subcitrate for 2 weeks. Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days. After the end of treatment regimens, 20 mg omeprazole was administered twice daily for 3 weeks. H. pylori eradication was assessed 2 months after antibiotic treatment via fecal antigen. RESULTS: Frequency of H. pylori eradication in group A and B was observed in 55 (68.8%) and 63 patients (78.8%), respectively. No significant difference was seen between two groups, regarding H. pylori eradication (p = 0.15). The most common side effects in group A, B were bitterness of mouth (63.8%) and nausea (16.2%), respectively (p H. pylori infection, higher rate of H. pylori eradication was seen in group B than group A. Thus, sequential regimen was a more appropriate regimen with fewer complications.

• Klíčová slova
• H. pylori infection, Sequential therapy, eradication, standard triple-drug therapy,
• MeSH
• amoxicilin aplikace a dávkování   MeSH
• dospělí MeSH
• Helicobacter pylori MeSH
• infekce vyvolané Helicobacter pylori farmakoterapie   MeSH
• klarithromycin aplikace a dávkování   MeSH
• kombinovaná farmakoterapie MeSH
• levofloxacin aplikace a dávkování   MeSH
• lidé středního věku MeSH
• lidé MeSH
• omeprazol aplikace a dávkování   MeSH
• organokovové sloučeniny aplikace a dávkování   MeSH
• senioři MeSH
• tinidazol aplikace a dávkování   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• srovnávací studie MeSH
• Názvy látek
• amoxicilin MeSH
• bismuth tripotassium dicitrate MeSH Prohlížeč
• klarithromycin MeSH
• levofloxacin MeSH
• omeprazol MeSH
• organokovové sloučeniny MeSH
• tinidazol MeSH