BACKGROUND: The aim of this study was comparison the effectiveness of sequential and standard quadruple therapy on eradication of H. pylori infection. METHODS: This clinical trial study was conducted on 160 patients with dyspepsia or gastroduodenal ulcer. Patients were randomly divided into two groups. Group A (standard regimen) received omeprazole, amoxicillin, clarithromycin and bismuth subcitrate for 2 weeks. Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days. After the end of treatment regimens, 20 mg omeprazole was administered twice daily for 3 weeks. H. pylori eradication was assessed 2 months after antibiotic treatment via fecal antigen. RESULTS: Frequency of H. pylori eradication in group A and B was observed in 55 (68.8%) and 63 patients (78.8%), respectively. No significant difference was seen between two groups, regarding H. pylori eradication (p = 0.15). The most common side effects in group A, B were bitterness of mouth (63.8%) and nausea (16.2%), respectively (p H. pylori infection, higher rate of H. pylori eradication was seen in group B than group A. Thus, sequential regimen was a more appropriate regimen with fewer complications.
- Klíčová slova
- H. pylori infection, Sequential therapy, eradication, standard triple-drug therapy,
- MeSH
- amoxicilin aplikace a dávkování MeSH
- dospělí MeSH
- Helicobacter pylori MeSH
- infekce vyvolané Helicobacter pylori farmakoterapie MeSH
- klarithromycin aplikace a dávkování MeSH
- kombinovaná farmakoterapie MeSH
- levofloxacin aplikace a dávkování MeSH
- lidé středního věku MeSH
- lidé MeSH
- omeprazol aplikace a dávkování MeSH
- organokovové sloučeniny aplikace a dávkování MeSH
- senioři MeSH
- tinidazol aplikace a dávkování MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- srovnávací studie MeSH
- Názvy látek
- amoxicilin MeSH
- bismuth tripotassium dicitrate MeSH Prohlížeč
- klarithromycin MeSH
- levofloxacin MeSH
- omeprazol MeSH
- organokovové sloučeniny MeSH
- tinidazol MeSH
Antitrichomonal activity of selected 2,4-dinitro-phenylhydrazones and phenylosazones of sugars was investigated in vitro and in vivo and compared with the activity of tinidazole, an effective therapeutic agent. In experimental infections with Trichomonas vaginalis and Tritrichomonas foetus in mice glycolaldehyde-2,4-dinitro-phenylhydrazone acetate and 2,3-diacetylglycerolaldehyde-2,4-dinitro-phenylhydrazone exhibited an antiparasitic effect slightly inferior to that of tinidazole. Structure-activity relationships are discussed. On the basis of the results obtained the chemotherapeutic value of the mentioned substances seems to be promising.
- MeSH
- absces farmakoterapie MeSH
- acetaldehyd * analogy a deriváty MeSH
- antitrichomonádové látky chemická syntéza MeSH
- diglyceridy chemická syntéza farmakologie MeSH
- glyceridy chemická syntéza MeSH
- hydrazony chemická syntéza farmakologie MeSH
- myši MeSH
- peritonitida farmakoterapie parazitologie MeSH
- tinidazol terapeutické užití MeSH
- trichomonádová vaginitida farmakoterapie parazitologie MeSH
- Trichomonas vaginalis účinky léků MeSH
- trichomoniáza farmakoterapie parazitologie MeSH
- Tritrichomonas účinky léků MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 2,3-di-O-acetylglyceroaldehyde-2,4-dinitrophenylhydrazone MeSH Prohlížeč
- acetaldehyd * MeSH
- antitrichomonádové látky MeSH
- diglyceridy MeSH
- glyceridy MeSH
- glycoaldehyde-2,4-dinitrophenylhydrazone acetate MeSH Prohlížeč
- hydrazony MeSH
- tinidazol MeSH
