Wnt signaling cascade has developed together with multicellularity to orchestrate the development and homeostasis of complex structures. Wnt pathway components - such as β-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade and are believed to function primarily in the Wnt cascade. It is interesting to see that in recent literature many of these proteins are connected with cellular functions that are more ancient and not limited to multicellular organisms - such as cell cycle regulation, centrosome biology, or cell division. In this review, we summarize the recent literature describing this crosstalk. Specifically, we attempt to find the answers to the following questions: Is the response to Wnt ligands regulated by the cell cycle? Is the centrosome and/or cilium required to activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal cycle and cilia formation and function? We critically review the evidence that describes how these connections are regulated and how they help to integrate cell-to-cell communication with the cell and the centrosomal cycle in order to achieve a fine-tuned, physiological response.

• Klíčová slova
• Wnt, cell cycle, centrosome, cilium, crosstalk, planar cell polarity,
• MeSH
• buněčný cyklus * MeSH
• centrozom metabolismus   MeSH
• lidé MeSH
• mezibuněčná komunikace MeSH
• polarita buněk MeSH
• signální dráha Wnt * MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Members of the Tcf/Lef family of the HMG box transcription factors are nuclear effectors of the Wnt signal transduction pathway. Upon Wnt signaling, TCF/LEF proteins interact with beta-catenin and activate transcription of target genes, while, in the absence of the Wnt signal, TCFs function as transcriptional repressors. All vertebrate Tcf/Lef transcription factors associate with TLE/Groucho-related co-repressors, and here we provide evidence for an interaction between the C-terminus of the TCF-4 HMG box protein and the C-terminal binding protein 1 (CtBP1) transcriptional co-repressor. Using Wnt-1-stimulated human embryonic kidney 293 cells, we show that CtBP1 represses the transcriptional activity of a Tcf/beta-catenin-dependent synthetic promoter and, furthermore, decreases the expression of the endogenous Wnt target, Axin2/Conductin. The CtBP1-mediated repression was alleviated by trichostatin A treatment, indicating that the CtBP inhibitory mechanism is dependent on the activity of histone deacetylases.

• MeSH
• alkoholoxidoreduktasy MeSH
• axin protein MeSH
• beta-katenin MeSH
• buněčné linie MeSH
• COS buňky MeSH
• cytoskeletální proteiny genetika   metabolismus   MeSH
• DNA vazebné proteiny genetika   metabolismus   MeSH
• fosfoproteiny genetika   metabolismus   MeSH
• genetická transkripce MeSH
• kokultivační techniky MeSH
• korepresorové proteiny MeSH
• krysa rodu Rattus MeSH
• kyseliny hydroxamové farmakologie   MeSH
• lidé MeSH
• messenger RNA genetika   metabolismus   MeSH
• molekulární sekvence - údaje MeSH
• myši MeSH
• plazmidy genetika   MeSH
• protein 2 podobný transkripčnímu faktoru 7 MeSH
• protein Wnt1 MeSH
• proteiny dánia pruhovaného * MeSH
• proteiny Wnt MeSH
• protoonkogenní proteiny genetika   fyziologie   MeSH
• regulace genové exprese účinky léků   MeSH
• represorové proteiny genetika   metabolismus   MeSH
• sekvence aminokyselin MeSH
• sekvenční homologie aminokyselin MeSH
• trans-aktivátory genetika   metabolismus   MeSH
• transfekce MeSH
• transkripční faktory TCF MeSH
• transkripční faktory genetika   metabolismus   MeSH
• vazba proteinů MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• alkoholoxidoreduktasy MeSH
• axin protein MeSH
• AXIN2 protein, human MeSH Prohlížeč
• Axin2 protein, mouse MeSH Prohlížeč
• beta-katenin MeSH
• C-terminal binding protein MeSH Prohlížeč
• Ctbp2 protein, mouse MeSH Prohlížeč
• CTNNB1 protein, human MeSH Prohlížeč
• CTNNB1 protein, mouse MeSH Prohlížeč
• Ctnnb1 protein, rat MeSH Prohlížeč
• cytoskeletální proteiny MeSH
• DNA vazebné proteiny MeSH
• fosfoproteiny MeSH
• korepresorové proteiny MeSH
• kyseliny hydroxamové MeSH
• messenger RNA MeSH
• protein 2 podobný transkripčnímu faktoru 7 MeSH
• protein Wnt1 MeSH
• proteiny dánia pruhovaného * MeSH
• proteiny Wnt MeSH
• protoonkogenní proteiny MeSH
• represorové proteiny MeSH
• TCF7L2 protein, human MeSH Prohlížeč
• Tcf7l2 protein, mouse MeSH Prohlížeč
• Tcf7l2 protein, rat MeSH Prohlížeč
• trans-aktivátory MeSH
• transkripční faktory TCF MeSH
• transkripční faktory MeSH
• trichostatin A MeSH Prohlížeč
• WNT1 protein, human MeSH Prohlížeč
• Wnt1 protein, mouse MeSH Prohlížeč
• Wnt1 protein, rat MeSH Prohlížeč