Wnt signaling cascade has developed together with multicellularity to orchestrate the development and homeostasis of complex structures. Wnt pathway components - such as β-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade and are believed to function primarily in the Wnt cascade. It is interesting to see that in recent literature many of these proteins are connected with cellular functions that are more ancient and not limited to multicellular organisms - such as cell cycle regulation, centrosome biology, or cell division. In this review, we summarize the recent literature describing this crosstalk. Specifically, we attempt to find the answers to the following questions: Is the response to Wnt ligands regulated by the cell cycle? Is the centrosome and/or cilium required to activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal cycle and cilia formation and function? We critically review the evidence that describes how these connections are regulated and how they help to integrate cell-to-cell communication with the cell and the centrosomal cycle in order to achieve a fine-tuned, physiological response.

b Molecular and Cellular Exercise Physiology Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden

c Department of Histology and Embryology Faculty of Medicine Masaryk University Brno Czech Republic

Department of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic

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Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein

Linking planar polarity signalling to actomyosin contractility during vertebrate neurulation

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling

KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling

Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2

Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs

Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells