The sol-gel derived porous bioactive glasses have drawn worldwide attention by virtue of the convenience and flexibility of this versatile synthesis method. In this review, the recent advances in sol-gel processed porous bioactive glasses in biomedical fields, especially for bone tissue regeneration applications have been comprehensively reviewed. Generally, it is envisaged that the morphology and chemical compositions of sol-gel derived porous bioactive glasses significantly affect their biological properties. Therefore, the controlled synthesis of these porous glasses is critical to their effective use in the biomedical fields. With this context, the first part of the review briefly describes the fundamentals of the sol-gel technique. In the subsequent section, different approaches frequently used for the sol-gel synthesis of porous glasses such as microemulsion and acid-catalyzed based synthesis have been reviewed. In the later part of the review, different types of sol-gel derived bioactive glasses namely silica, phosphate and silica-titania based glasses along with organic-inorganic hybrids materials have been discussed. The review also discusses the chemical, surface, mechanical and biological properties and further highlights the strategies to control the pore structure, shape, size and compositions of sol-gel derived bioactive glasses. Finally, the review provides a detailed discussion about the bone tissue regeneration application of different types of sol-gel derived bioactive glasses and presents future research perspectives.

• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Incisional hernia is the most common postoperative complication, affecting up to 20% of patients after abdominal surgery. Insertion of a synthetic surgical mesh has become the standard of care in ventral hernia repair. However, the implementation of a mesh does not reduce the risk of recurrence and the onset of hernia recurrence is only delayed by 2-3 years. Nowadays, more than 100 surgical meshes are available on the market, with polypropylene the most widely used for ventral hernia repair. Nonetheless, the ideal mesh does not exist yet; it still needs to be developed. Polycaprolactone nanofibers appear to be a suitable material for different kinds of cells, including fibroblasts, chondrocytes, and mesenchymal stem cells. The aim of the study reported here was to develop a functionalized scaffold for ventral hernia regeneration. We prepared a novel composite scaffold based on a polypropylene surgical mesh functionalized with poly-ε-caprolactone (PCL) nanofibers and adhered thrombocytes as a natural source of growth factors. In extensive in vitro tests, we proved the biocompatibility of PCL nanofibers with adhered thrombocytes deposited on a polypropylene mesh. Compared with polypropylene mesh alone, this composite scaffold provided better adhesion, growth, metabolic activity, proliferation, and viability of mouse fibroblasts in all tests and was even better than a polypropylene mesh functionalized with PCL nanofibers. The gradual release of growth factors from biocompatible nanofiber-modified scaffolds seems to be a promising approach in tissue engineering and regenerative medicine.

• Klíčová slova
• growth factors, hernia regeneration, in vitro, nanofibers, polypropylene mesh,
• MeSH
• biokompatibilní materiály * chemie   toxicita   MeSH
• chirurgické síťky * MeSH
• incizní kýla chirurgie   MeSH
• myši MeSH
• nanovlákna * chemie   toxicita   MeSH
• polyestery * chemie   toxicita   MeSH
• polypropyleny * chemie   toxicita   MeSH
• proliferace buněk účinky léků   MeSH
• trombocyty cytologie   MeSH
• viabilita buněk účinky léků   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• biokompatibilní materiály * MeSH
• polycaprolactone MeSH Prohlížeč
• polyestery * MeSH
• polypropyleny * MeSH