Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks. Classes of fatty acid epoxylipids and their enzymatic regulation by soluble epoxide hydrolase (sEH) have been implicated in coronary artery dysfunction, inflammation, and mitochondrial dysfunction in heart diseases. Likewise, genetic and pharmacological manipulations of epoxylipids have been demonstrated to have therapeutic benefits for heart diseases. Increasing epoxylipids reduce cardiac hypertrophy and fibrosis and improve cardiac function. Beneficial actions for epoxylipids have been demonstrated in cardiac ischemia reperfusion injury, electrical conductance abnormalities and arrhythmias, and ventricular tachycardia. This review discusses past and recent findings on the contribution of epoxylipids in heart diseases and the potential for their manipulation to treat heart attacks, arrhythmias, ventricular tachycardia, and heart failure.

• Klíčová slova
• Coronary artery, Cytochrome P450, Eicosanoids, Heart failure, Hypertension, Inflammation, Mitochondrial function, Myocardial infarction, Soluble epoxide hydrolase,
• MeSH
• epoxid hydrolasy antagonisté a inhibitory   metabolismus   MeSH
• epoxidové sloučeniny chemie   metabolismus   MeSH
• infarkt myokardu farmakoterapie   enzymologie   metabolismus   MeSH
• inhibitory enzymů terapeutické užití   MeSH
• komorová tachykardie farmakoterapie   enzymologie   metabolismus   MeSH
• lidé MeSH
• mastné kyseliny metabolismus   MeSH
• nemoci srdce farmakoterapie   enzymologie   metabolismus   MeSH
• rozpustnost MeSH
• srdeční arytmie farmakoterapie   enzymologie   metabolismus   MeSH
• srdeční selhání farmakoterapie   enzymologie   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Research Support, N.I.H., Extramural MeSH
• Názvy látek
• epoxid hydrolasy MeSH
• epoxidové sloučeniny MeSH
• inhibitory enzymů MeSH
• mastné kyseliny MeSH