In this study, we have compared four 68Ga-labeled peptides (three Arg-Gly-Asp (RGD) peptides and substance-P) with two 18F-tracers clinically approved for tumor imaging. We have studied in vitro and in vivo characteristics of selected radiolabeled tracers in a glioblastoma multiforme tumor model. The in vitro part of the study was mainly focused on the evaluation of radiotracers stability under various conditions. We have also determined in vivo stability of studied 68Ga-radiotracers by analysis of murine urine collected at various time points after injection. The in vivo behavior of tested 68Ga-peptides was evaluated through ex vivo biodistribution studies and PET/CT imaging. The obtained data were compared with clinically used 18F-tracers. 68Ga-RGD peptides showed better imaging properties compared to 18F-tracers, i.e., higher tumor/background ratios and no accumulation in non-target organs except for excretory organs.

• Klíčová slova
• 18F-FDG, 18F-FLT, PET, RGD peptides, biodistribution, gallium-68, glioblastoma multiforme,
• MeSH
• glioblastom diagnostické zobrazování   metabolismus   MeSH
• lidé MeSH
• myši SCID MeSH
• nádorové buněčné linie MeSH
• nádory mozku diagnostické zobrazování   metabolismus   MeSH
• oligopeptidy chemie   MeSH
• PET/CT MeSH
• počítačová rentgenová tomografie MeSH
• pozitronová emisní tomografie metody   MeSH
• radiofarmaka chemie   MeSH
• radioizotopy fluoru MeSH
• radioizotopy galia chemie   MeSH
• tkáňová distribuce MeSH
• transplantace nádorů MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• arginyl-glycyl-aspartic acid MeSH Prohlížeč
• Fluorine-18 MeSH Prohlížeč
• oligopeptidy MeSH
• radiofarmaka MeSH
• radioizotopy fluoru MeSH
• radioizotopy galia MeSH