The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.

• MeSH
• Biomarkers MeSH
• C-Reactive Protein analysis   MeSH
• Chemokines blood   MeSH
• Adult MeSH
• alpha-2-HS-Glycoprotein analysis   MeSH
• Body Mass Index MeSH
• Middle Aged MeSH
• Humans MeSH
• Osteopontin blood   MeSH
• Psoriasis complications   MeSH
• Heart Disease Risk Factors * MeSH
• Case-Control Studies MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• AHSG protein, human MeSH Browser
• Biomarkers MeSH
• C-Reactive Protein MeSH
• Chemokines MeSH
• alpha-2-HS-Glycoprotein MeSH
• Osteopontin MeSH
• RARRES2 protein, human MeSH Browser
• SPP1 protein, human MeSH Browser

Psoriasis is associated with metabolic activity of adipose tissue which produces pro- and anti-inflammatory adipokines. Goeckerman therapy (GT) represents an effective treatment of psoriasis. This study evaluated variation of selected inflammatory and metabolic markers during GT and the relationships between the markers, severity of the disease (PASI score), body mass, and the basic characteristics of the therapy. The study was conducted on a group of patients (n = 32) and on a control group (n = 24). Before GT, we found significantly elevated levels of proinflammatory CRP (p < 0.001) and leptin (p < 0.05) in psoriatic patients (compared to the controls). The therapy significantly decreased the levels of CRP and adiponectin. We found positive correlations between CRP and total duration of GT (p < 0.05) and CRP and the time of UV exposure (p < 0.01) and negative correlations between adiponectin and the total duration of GT (p < 0.05) and adiponectin and the application of CCT ointment (p < 0.001). From our results, we can conclude that GT causes partial reduction of both proinflammatory and anti-inflammatory markers. However, the levels of proinflammatory CRP and leptin remained significantly higher in the patients than in the control group.

• MeSH
• Adiponectin blood   MeSH
• Biomarkers MeSH
• C-Reactive Protein analysis   MeSH
• Adult MeSH
• Body Mass Index MeSH
• Leptin blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Ointments MeSH
• Psoriasis blood   drug therapy   MeSH
• Aged MeSH
• Severity of Illness Index MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Adiponectin MeSH
• Biomarkers MeSH
• C-Reactive Protein MeSH
• Leptin MeSH
• Ointments MeSH