Protein oxidation, the process caused especially by reactive oxygen and nitrogen species, is thought to play a major role in various oxidative processes within cells and is implicated in the development of many human diseases. This review provides a brief overview of the protein oxidation with the emphasis on the types of oxidation (oxidation of protein backbone and amino acid residues side chains, site-specific metal-catalysed protein oxidation), oxidationdependent generation of protein hydroperoxides, carbonyl derivatives and protein-protein cross-linkages. Nonenzymatic glycoxidation (also known as Maillard reaction) as an important factor of protein damage, consequences of oxidative protein impairment and related diseases as well as means of monitoring and assessment of protein modifications are discussed.

• MeSH
• Amino Acids chemistry   MeSH
• Diabetic Retinopathy pathology   MeSH
• Diabetic Neuropathies pathology   MeSH
• Cataract pathology   MeSH
• Oxygen metabolism   MeSH
• Humans MeSH
• Maillard Reaction * MeSH
• Oxidation-Reduction * MeSH
• Oxidative Stress physiology   MeSH
• Proteins chemistry   MeSH
• Reactive Nitrogen Species metabolism   MeSH
• Reactive Oxygen Species metabolism   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH
• Names of Substances
• Amino Acids MeSH
• Oxygen MeSH
• Proteins MeSH
• Reactive Nitrogen Species MeSH
• Reactive Oxygen Species MeSH