We have prepared photoactive multifunctional nanofiber membranes via the simple electrospinning method. The antibacterial and photocatalytic properties of these materials are based on the generation of singlet oxygen formed by processes photosensitized by the tetraphenylporphyrin encapsulated in the nanofibers. The addition of magnetic features in the form of magnetic maghemite (γ-Fe2O3) nanoparticles stabilized by polyethylenimine enables additional functionalities, namely, the postirradiation formation of hydrogen peroxide and improved photothermal properties. This hybrid material allows for remote manipulation by a magnetic field, even in hazardous and/or highly microbial contaminant environments.

• Publikační typ
• časopisecké články MeSH

We prepared antibacterial polystyrene nanoparticles (NPs) with natural photosensitizers from chlorophyll (Chl) extract via a simple nanoprecipitation method using the same solvent for dissolution of the polystyrene matrix and extraction of Chls from spinach leaves. A high photo-oxidation and antibacterial effect was demonstrated on Escherichia coli and was based on the photogeneration of singlet oxygen O2(1Δg), which was directly monitored by NIR luminescence measurements and indirectly verified using a chemical trap. The photoactivity of NPs was triggered by visible light, with enhanced red absorption by Chls. To reduce the quenching effect of carotenoids (β-carotene, lutein, etc.) in the Chl extract, diluted and/or preirradiated samples, in which the photo-oxidized carotenoids lose their quenching effect, were used for preparation of the NPs. For enhanced photo-oxidation and antibacterial effects, a sulfonated polystyrene matrix was used for preparation of a stable dispersion of sulfonated NPs, with the quenching effect of carotenoids being suppressed.

• Publikační typ
• časopisecké články MeSH

Novel biomaterials based on hydrophilic polycaprolactone and polyurethane (Tecophilic®) nanofibers with an encapsulated 5,10,5,20-tetraphenylporphyrin photosensitizer were prepared by electrospinning. The doped nanofiber textiles efficiently photo-generate O(2)((1)Δ(g)), which oxidize external chemical and biological substrates/targets. Strong photo-virucidal effects toward non-enveloped polyomaviruses and enveloped baculoviruses were observed on the surface of these textiles. The photo-virucidal effect was confirmed by a decrease in virus infectivity. In contrast, no virucidal effect was detected in the absence of light and/or the encapsulated photosensitizer.

• MeSH
• anthraceny chemie   MeSH
• antivirové látky farmakologie   MeSH
• Baculoviridae účinky léků   MeSH
• fotosenzibilizující látky farmakologie   MeSH
• inaktivace viru účinky léků   MeSH
• kapsida chemie   MeSH
• myši MeSH
• nanovlákna chemie   ultrastruktura   MeSH
• oxidace-redukce MeSH
• polyestery chemie   MeSH
• Polyomavirus účinky léků   MeSH
• polyurethany chemie   MeSH
• porfyriny farmakologie   MeSH
• rekombinace genetická genetika   MeSH
• singletový kyslík metabolismus   MeSH
• textilie * MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• anthraceny MeSH
• antivirové látky MeSH
• fotosenzibilizující látky MeSH
• polycaprolactone MeSH Prohlížeč
• polyestery MeSH
• polyurethany MeSH
• porfyriny MeSH
• singletový kyslík MeSH
• tetraphenylporphyrin MeSH Prohlížeč