Using supramolecular self-assembled nanocomposite materials made from protein and polysaccharide components is becoming more popular because of their unique properties, such as biodegradability, hierarchical structures, and tunable multifunctionality. However, the fabrication of these materials in a reproducible way remains a challenge. This study presents a new evaporation-induced self-assembly method producing layered hydrogel membranes (LHMs) using tropocollagen grafted by partially deacetylated chitin nanocrystals (CO-g-ChNCs). ChNCs help stabilize tropocollagen's helical conformation and fibrillar structure by forming a hierarchical microstructure through chemical and physical interactions. The LHMs show improved mechanical properties, cytocompatibility, and the ability to control drug release using octenidine dihydrochloride (OCT) as a drug model. Because of the high synergetic performance between CO and ChNCs, the modulus, strength, and toughness increased significantly compared to native CO. The biocompatibility of LHM was tested using the normal human dermal fibroblast (NHDF) and the human osteosarcoma cell line (Saos-2). Cytocompatibility and cell adhesion improved with the introduction of ChNCs. The extracted ChNCs are used as a reinforcing nanofiller to enhance the performance properties of tropocollagen hydrogel membranes and provide new insights into the design of novel LHMs that could be used for various medical applications, such as control of drug release in the skin and bone tissue regeneration.

• MeSH
• Biocompatible Materials * chemistry   MeSH
• Chitin * chemistry   MeSH
• Fibroblasts MeSH
• Hydrogels * chemistry   MeSH
• Imines pharmacokinetics   MeSH
• Protein Conformation, alpha-Helical MeSH
• Delayed-Action Preparations * chemistry   MeSH
• Humans MeSH
• Mechanical Phenomena MeSH
• Membranes chemistry   MeSH
• Cell Line, Tumor MeSH
• Nanoparticles chemistry   MeSH
• Nanocomposites * chemistry   MeSH
• Pyridines pharmacokinetics   MeSH
• Tropocollagen * chemistry   MeSH
• Drug Liberation MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Biocompatible Materials * MeSH
• Chitin * MeSH
• Hydrogels * MeSH
• Imines MeSH
• Delayed-Action Preparations * MeSH
• octenidine MeSH Browser
• Pyridines MeSH
• Tropocollagen * MeSH

We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.

• Publication type
• Journal Article MeSH

The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible alternatives to synthetic materials. Their unique properties and abundance in marine sources make them valuable resources for various biomedical and industrial applications. Due to high biocompatible features and participation in biological processes related to tissue healing, hyaluronic acid has become widely used in tissue engineering applications, especially in the wound healing process. The present review enlightens marine hyaluronan biomaterial providing its sources, extraction process, structures, chemical modifications, biological properties, and biocidal applications, especially for wound healing/dressing purposes. Meanwhile, we point out the future development of wound healing/dressing based on hyaluronan and its composites and potential challenges.

• Keywords
• characterization, composites, extraction process, hyaluronan, marine sources, wound healing applications,
• MeSH
• Biocompatible Materials pharmacology   MeSH
• Wound Healing MeSH
• Hyaluronic Acid * pharmacology   MeSH
• Bandages * MeSH
• Tissue Engineering MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Biocompatible Materials MeSH
• Hyaluronic Acid * MeSH

Wounds are structural and functional disruptions of skin that occur because of trauma, surgery, acute illness, or chronic disease conditions. Chronic wounds are caused by a breakdown in the finely coordinated cascade of events that occurs during healing. Wound healing is a long process that split into at least three continuous and overlapping processes: an inflammatory response, a proliferative phase, and finally the tissue remodeling. Therefore, these processes are extensively studied to develop novel therapeutics in order to achieve maximum recovery with minimum scarring. Several growth hormones and cytokines secreted at the site of lesions tightly regulates the healing processes. The traditional approach for wound management has been represented by topical treatments. Metal nanoparticles (e.g., silver, gold and zinc) are increasingly being employed in dermatology due to their favorable effects on healing, as well as in treating and preventing secondary bacterial infections. In the current review, a brief introduction on traditional would healing approach is provided, followed by focus on the potential of wound dressing therapeutic techniques functionalized with Ag-NPs.

• Keywords
• dermatology, inflammatory response, silver nanoparticles, wound, wound healing,
• MeSH
• Anti-Bacterial Agents therapeutic use   MeSH
• Wound Healing MeSH
• Metal Nanoparticles * chemistry   therapeutic use   MeSH
• Bandages MeSH
• Silver * chemistry   therapeutic use   MeSH
• Gold chemistry   MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Silver * MeSH
• Gold MeSH