OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results. RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients. CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.

• Klíčová slova
• COVID-19, Dp-ucMGP, Elastic fibers, Matrix Gla Protein, Vitamin K,
• MeSH
• biologické markery MeSH
• COVID-19 * MeSH
• extracelulární matrix - proteiny MeSH
• lidé MeSH
• nedostatek vitaminu K * komplikace   MeSH
• proteiny vázající vápník MeSH
• SARS-CoV-2 MeSH
• vitamin K MeSH
• výdaje na zdravotnictví MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• biologické markery MeSH
• extracelulární matrix - proteiny MeSH
• proteiny vázající vápník MeSH
• vitamin K MeSH