The current study investigates and compares the biological effects of ultrathin conformal coatings of zirconium dioxide (ZrO2) and vanadium pentoxide (V2O5) on osteoblastic MG-63 cells grown on TiO2 nanotube layers (TNTs). Coatings were achieved by the atomic layer deposition (ALD) technique. TNTs with average tube diameters of 15, 30, and 100 nm were fabricated on Ti substrates (via electrochemical anodization) and were used as primary substrates for the study. The MG-63 cell growth and proliferation after 48 h of incubation on hybrid TNTs/ZrO2 and TNTs/V2O5 surfaces was evaluated in comparison to the uncoated TNTs of each diameter. The density of viable MG-63 cells was assessed for all the TNT surfaces, along with the cell morphology and the spreading behavior (i.e., the cell length). The ultrathin coatings retained the original morphology of the TNTs but changed the surface chemical composition, wettability, and cell behavior, whose interplay is the subject of the present investigation. These findings offer interesting views on the influence of the composition of biomedical implant surfaces, triggered by ALD ultrathin coatings on them. The outcomes of this work shed light on the assessment of the biocompatibility of the two different ALD coatings.

• Klíčová slova
• MG-63, TiO2 nanotube layers, ZrO2, V2O5, atomic layer deposition, cell viability.,
• MeSH
• biokompatibilní potahované materiály * chemie   farmakologie   MeSH
• buněčné linie MeSH
• elektrody MeSH
• lidé MeSH
• nanotrubičky * chemie   MeSH
• osteoblasty * účinky léků   cytologie   MeSH
• povrchové vlastnosti MeSH
• proliferace buněk * účinky léků   MeSH
• sloučeniny vanadu chemie   farmakologie   MeSH
• titan * chemie   farmakologie   MeSH
• zirkonium * chemie   farmakologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• biokompatibilní potahované materiály * MeSH
• sloučeniny vanadu MeSH
• titan * MeSH
• titanium dioxide MeSH Prohlížeč
• vanadium pentoxide MeSH Prohlížeč
• zirconium oxide MeSH Prohlížeč
• zirkonium * MeSH

In this study, crystallization of amorphous TiO2 nanotube (TNT) layers upon optimized laser annealing is shown. The resulting anatase TNT layers do not show any signs of deformation or melting. The crystallinity of the laser annealed TNT layers was investigated using X-ray diffraction, Raman spectroscopy, and high-resolution transmission electron microscopy (HRTEM). The study of the (photo-)electrochemical properties showed that the laser annealed TNT layers were more defective than conventional TNT layers annealed in a muffle oven at 400 °C, resulting in a higher charge recombination rate and lower photocurrent response. However, a lower overpotential for hydrogen evolution reaction was observed for the laser annealed TNT layer compared to the oven annealed TNT layer.

• Publikační typ
• časopisecké články MeSH