By the April 12, 2022, the COVID-19 pandemic had resulted in over half a billion people being infected worldwide. There have been 6.1 million deaths directly due to the infection, but the pandemic has had many more short- and long-term pervasive effects on the physical and mental health of the population. Allergic diseases are among the most prevalent noncommunicable chronic diseases in the pediatric population, and health-care professionals and researchers were seeking answers since the beginning of pandemic. Children are at lower risk of developing severe COVID-19 or dying from infection. Allergic diseases are not associated with a higher COVID-19 severity and mortality, apart from severe/poorly controlled asthma. The pandemic disrupted routine health care, but many mitigation strategies, including but not limited to telemedicine, were successfully implemented to continue delivery of high-standard care. Although children faced a multitude of pandemic-related issues, allergic conditions were effectively treated remotely while reduction in air pollution and lack of contact with outdoor allergens resulted in improvement, particularly respiratory allergies. There is no evidence to recommend substantial changes to usual management modalities of allergic conditions in children, including allergen immunotherapy and use of biologicals. Allergic children are not at greater risk of multisystem inflammatory syndrome development, but some associations with Long COVID were reported, although the data are limited, and further research is needed. This statement of the EAACI Section on Pediatrics provides recommendations based on the lessons learnt from the pandemic, as available evidence.

• Klíčová slova
• COVID-19, MIS-C, SARS-CoV-2, allergic diseases, allergy, asthma, care, children, eczema, food allergy, immunodeficiencies, lockdown, long covid, pandemic, post-covid-19 condition, vaccination,
• MeSH
• alergie * MeSH
• bronchiální astma * epidemiologie   MeSH
• COVID-19 * epidemiologie   MeSH
• dítě MeSH
• lidé MeSH
• pandemie MeSH
• postakutní syndrom COVID-19 MeSH
• syndromy imunologické nedostatečnosti * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.

• Klíčová slova
• COVID-19, SARS-CoV-2, allergy, coronavirus disease 2019, severe acute respiratory syndrome-related coronavirus 2,
• MeSH
• alergie komplikace   imunologie   terapie   MeSH
• Betacoronavirus imunologie   MeSH
• COVID-19 MeSH
• koronavirové infekce komplikace   diagnóza   terapie   MeSH
• lidé MeSH
• pandemie MeSH
• SARS-CoV-2 MeSH
• virová pneumonie komplikace   diagnóza   terapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.

• Klíčová slova
• COVID-19, PIMS-TS, SARS-CoV-2, hemophagocytic lymphohistiocytosis, innate immunity, macrophage activation syndrome, neutrophil, pediatric,
• MeSH
• Betacoronavirus * imunologie   metabolismus   MeSH
• COVID-19 MeSH
• dítě MeSH
• hormony kůry nadledvin aplikace a dávkování   MeSH
• imunosupresivní léčba * MeSH
• intravenózní imunoglobuliny aplikace a dávkování   MeSH
• koronavirové infekce * krev   diagnóza   farmakoterapie   imunologie   MeSH
• lidé MeSH
• lymfohistiocytóza hemofagocytární * diagnóza   farmakoterapie   imunologie   MeSH
• neutrofily MeSH
• pandemie * MeSH
• SARS-CoV-2 MeSH
• syndrom aktivovaných makrofágů * diagnóza   farmakoterapie   imunologie   MeSH
• virová pneumonie * krev   diagnóza   farmakoterapie   imunologie   MeSH
• zánět diagnóza   farmakoterapie   imunologie   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• hormony kůry nadledvin MeSH
• intravenózní imunoglobuliny MeSH