MXene-based nanozymes have garnered considerable attention because of their potential environmental and biomedical applications. These materials encompass alluring and manageable catalytic performances and physicochemical features, which make them suitable as (bio)sensors with high selectivity/sensitivity and efficiency. MXene-based structures with suitable electrical conductivity, biocompatibility, large surface area, optical/magnetic properties, and thermal/mechanical features can be applied in designing innovative nanozymes with area-dependent electrocatalytic performances. Despite the advances made, there is still a long way to deploy MXene-based nanozymes, especially in medical and healthcare applications; limitations pertaining the peroxidase-like activity and sensitivity/selectivity may restrict further practical applications of pristine MXenes. Thus, developing an efficient surface engineering tactic is still required to fabricate multifunctional MXene-based nanozymes with excellent activity. To obtain MXene-based nanozymes with unique physicochemical features and high stability, some crucial steps such as hybridization and modification ought to be performed. Notably, (nano)toxicological and long-term biosafety analyses along with clinical translation studies still need to be comprehensively addressed. Although very limited reports exist pertaining to the biomedical potentials of MXene-based nanozymes, the future explorations should transition toward the extensive research and detailed analyses to realize additional potentials of these structures in biomedicine with a focus on clinical and industrial aspects. In this perspective, therapeutic, diagnostic, and theranostic applications of MXene-based nanozymes are deliberated with a focus on future perspectives toward more successful clinical translational studies. The current state-of-the-art biomedical advances in the use of MXene-based nanozymes, as well as their developmental challenges and future prospects are also highlighted. In view of the fascinating properties of MXene-based nanozymes, these materials can open significant new opportunities in the future of bio- and nanomedicine.

• Keywords
• Diagnostics, MXene-based nanozymes, MXenes, Theranostics, Therapeutics,
• Publication type
• Journal Article MeSH

The functionalization of nanomaterials with suitable capping ligands or bioactive agents is an interesting strategy in designing nanosystems with suitable applicability and biocompatibility; the physicochemical and biological properties of these nanomaterials can be highly improved for biomedical applications. In this context, numerous explorations have been conducted in the functionalization of silver (Ag) and gold (Au) nanomaterials using suitable functional groups or agents to design nanosystems with unique physicochemical properties such as excellent biosensing capabilities, biocompatibility, targeting features, and multifunctionality for biomedical purposes. Future studies should be undertaken for designing novel functionalization tactics to improve the properties of Au- and Ag-based nanosystems and reduce their toxicity. The possible release of cytotoxic radicals or ions, the internalization of nanomaterials, the alteration of cellular signaling pathways, the translocation of these nanomaterials across the cell membranes into mitochondria, DNA damages, and the damage of cell membranes are the main causes of their toxicity, which ought to be comprehensively explored. In this study, recent advancements in diagnostic and therapeutic applications of functionalized Au and Ag nanomaterials are deliberated, focusing on important challenges and future directions.

• Keywords
• biosensing, cancer theranostics, drug delivery, functionalization, gold nanomaterials, silver nanomaterials,
• Publication type
• Journal Article MeSH
• Review MeSH

Today, MXenes with fascinating electronic, thermal, optical, and mechanical features have been broadly studied for biomedical applications, such as drug/gene delivery, photothermal/photodynamic therapy, antimicrobials/antivirals, sensing, tissue engineering, and regenerative medicine. In this context, various MXene-polymer composites have been designed to improve the characteristics such as physiological stability, sustained/controlled release behaviors, biodegradability, biocompatibility, selectivity/sensitivity, and functionality. Chitosan with advantages of ease of modification, biodegradability, antibacterial activities, non-toxicity, and biocompatibility can be considered as attractive materials for designing hybridized composites together with MXenes. These hybrid composites ought to be further explored for biomedical applications because of their unique properties such as high photothermal conversion efficiency, improved stability, selectivity/sensitivity, stimuli-responsiveness behaviors, and superior antibacterial features. These unique structural, functional, and biological attributes indicate that MXene-chitosan composites are attractive alternatives in biomedical engineering. However, several crucial aspects regarding the surface functionalization/modification, hybridization, nanotoxicological analyses, long-term biosafety assessments, biocompatibility, in vitro/in vivo evaluations, identification of optimization conditions, implementation of environmentally-benign synthesis techniques, and clinical translation studies are still need to be examined by researchers. Although very limited studies have revealed the great potentials of MXene-chitosan hybrids in biomedicine, the next steps should be toward the extensive research and detailed analyses in optimizing their properties and improving their functionality with a clinical and industrial outlook. Herein, recent developments in the use of MXene-chitosan composites with biomedical potentials are deliberated, with a focus on important challenges and future perspectives. In view of the fascinating properties and multifunctionality of MXene-chitosan composites, these hybrid materials can open significant new opportunities in the future for bio- and nano-medicine arena.

• Keywords
• MXene-based nanosystems, MXene-chitosan composites, MXenes, biomedicine, chitosan,
• Publication type
• Journal Article MeSH
• Review MeSH

Graphene-based materials have shown immense pertinence for sensing/imaging, gene/drug delivery, cancer therapy/diagnosis, and tissue engineering/regenerative medicine. Indeed, the large surface area, ease of functionalization, high drug loading capacity, and reactive oxygen species induction potentials have rendered graphene- (G-) and graphene oxide (GO)-based (nano)structures promising candidates for cancer therapy applications. Various techniques namely liquid-phase exfoliation, Hummer's method, chemical vapor deposition, chemically reduced GO, mechanical cleavage of graphite, arc discharge of graphite, and thermal fusion have been deployed for the production of G-based materials. Additionally, important criteria such as biocompatibility, bio-toxicity, dispersibility, immunological compatibility, and inflammatory reactions of G-based structures need to be systematically assessed for additional clinical and biomedical appliances. Furthermore, surface properties (e.g., lateral dimension, charge, corona influence, surface structure, and oxygen content), concentration, detection strategies, and cell types are vital for anticancer activities of these structures. Notably, the efficient accumulation of anticancer drugs in tumor targets/tissues, controlled cellular uptake properties, tumor-targeted drug release behavior, and selective toxicity toward the cells are crucial criteria that need to be met for developing future anticancer G-based nanosystems. Herein, important challenges and future perspectives of cancer therapy using G- and GO-based nanosystems have been highlighted, and the recent advancements are deliberated.

• Keywords
• cancer nanotherapy, graphene, graphene oxide, graphene‐based nanomaterials,
• Publication type
• Journal Article MeSH
• Review MeSH

The supply of safe drinking and clean water is becoming increasingly challenging proposition throughout the world. The deployment of environmentally sustainable nanomaterials with unique advantages namely high efficiency and selectivity, earth-abundance, recyclability, low-cost of production processes, and stability, has been a priority although several important challenges and constraints still remained unresolved. Carbon nanomaterials namely activated carbon, multi-walled- and single-walled carbon nanotubes, have been developed and applied as adsorbents for wastewater treatment and purification; graphene and graphene oxide-based nanomaterials as well as carbon and graphene quantum dots-derived nanomaterials have shown significant promise for water and wastewater treatment and purification, especially, for industrial- and pharmaceutical-laden wastes. This review encompasses advanced carbonaceous nanomaterials and methodologies that are deployed for the elimination of contaminants and ionic metals in aqueous media, and as novel nanosorbents for wastewater, drinking and ground water treatment. Additionally, recent trends and challenges pertaining to the sustainable carbon and graphene quantum dots-derived nanomaterials and their appliances for treating and purifying wastewater are highlighted.

• Keywords
• Carbon dots, Carbon nanotubes, Graphene, Quantum dots, Sustainable nanomaterials, Wastewater treatment,
• MeSH
• Water Purification * MeSH
• Nanostructures * MeSH
• Nanotubes, Carbon * MeSH
• Wastewater MeSH
• Water MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Nanotubes, Carbon * MeSH
• Waste Water MeSH
• Water MeSH