Interferon (IFN)-related DNA damage resistant signature (IRDS) genes are a subgroup of interferon-stimulated genes (ISGs) found upregulated in different cancer types, which promotes resistance to DNA damaging chemotherapy and radiotherapy. Along with briefly discussing IFNs and signalling in this review, we highlighted how different IRDS genes are affected by viruses. On the contrary, different strategies adopted to suppress a set of IRDS genes (STAT1, IRF7, OAS family, and BST2) to induce (chemo- and radiotherapy) sensitivity were deliberated. Significant biological pathways that comprise these genes were classified, along with their frequently associated genes (IFIT1/3, IFITM1, IRF7, ISG15, MX1/2 and OAS1/3/L). Major upstream regulators from the IRDS genes were identified, and different IFN types regulating these genes were outlined. Functional interfaces of IRDS proteins with DNA/RNA/ATP/GTP/NADP biomolecules featured a well-defined pharmacophore model for STAT1/IRF7-dsDNA and OAS1/OAS3/IFIH1-dsRNA complexes, as well as for the genes binding to GDP or NADP+. The Lys amino acid was found commonly interacting with the ATP phosphate group from OAS1/EIF2AK2/IFIH1 genes. Considering the premise that targeting IRDS genes mediated resistance offers an efficient strategy to resensitize tumour cells and enhances the outcome of anti-cancer treatment, this review can add some novel insights to the field.

• Klíčová slova
• ATP, DNA, DNA damage, IRDS genes, RNA, chemotherapy and radiotherapy, functional site, interferon, protein interfaces, receptors, resistance, upstream regulator, viruses,
• MeSH
• adaptorové proteiny signální transdukční fyziologie   MeSH
• aktivace transkripce MeSH
• chemorezistence genetika   fyziologie   MeSH
• dvouvláknová RNA MeSH
• interferonový regulační faktor 7 MeSH
• interferony metabolismus   fyziologie   MeSH
• intracelulární signální peptidy a proteiny MeSH
• lidé MeSH
• nádorové buněčné linie MeSH
• poškození DNA genetika   fyziologie   MeSH
• proteiny vázající RNA MeSH
• signální transdukce MeSH
• transkripční faktor STAT1 MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• adaptorové proteiny signální transdukční MeSH
• dvouvláknová RNA MeSH
• IFIT1 protein, human MeSH Prohlížeč
• IFIT3 protein, human MeSH Prohlížeč
• interferonový regulační faktor 7 MeSH
• interferony MeSH
• intracelulární signální peptidy a proteiny MeSH
• IRF7 protein, human MeSH Prohlížeč
• proteiny vázající RNA MeSH
• STAT1 protein, human MeSH Prohlížeč
• transkripční faktor STAT1 MeSH