Due to their bioavailability, glycosylated carotenoids may have interesting biological effects. Sioxanthin, as a representative of this type of carotenoid, has been identified in marine actinomycetes of the genus Salinispora. This study evaluates, for the first time, the effect of cultivation temperature (T) and light intensity (LI) on the total cellular carotenoid content (TC), antioxidant activity (AA) and sioxanthin content (SX) of a crude extract (CE) from Salinispora tropica biomass in its vegetative state. Treatment-related differences in TC and SX values were statistically significantly and positively affected by T and LI, while AA was most significantly affected by T. In the S. tropica CE, TC correlated well (R2 = 0.823) with SX and somewhat less with AA (R2 = 0.777). A correlation between AA and SX was found to be less significant (R2 = 0.731). The most significant protective effect against oxidative stress was identified in the CE extracted from S. tropica biomass grown at the highest T and LI (CE-C), as was demonstrated using LNCaP and KYSE-30 human cell lines. The CE showed no cytotoxicity against LNCaP and KYSE-30 cell lines.

• Keywords
• Salinispora tropica, antioxidant activity, sioxanthin, total cellular carotenoids,
• MeSH
• Antioxidants chemistry   pharmacology   MeSH
• Biphenyl Compounds MeSH
• Biomass MeSH
• Cell Line drug effects   MeSH
• Carotenoids metabolism   pharmacology   MeSH
• Complex Mixtures MeSH
• Humans MeSH
• Micromonosporaceae * MeSH
• Mycelium MeSH
• Oxidative Stress drug effects   MeSH
• Picrates MeSH
• Light MeSH
• Temperature MeSH
• Aquatic Organisms MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• 1,1-diphenyl-2-picrylhydrazyl MeSH Browser
• Antioxidants MeSH
• Biphenyl Compounds MeSH
• Carotenoids MeSH
• Complex Mixtures MeSH
• Picrates MeSH
• sioxanthin MeSH Browser