Nejvíce citovaný článek - PubMed ID 37336550
Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture of early eukaryotic cellular complexity requires provision of analytical resources and a commitment to data sharing. Here, we summarise progress towards understanding the biology of LECA and outline a community approach to inferring its wider gene repertoire. Once assembled, a robust LECA gene set will be a useful tool for evaluating alternative hypotheses about the origin of eukaryotes and understanding the evolution of traits in all descendant lineages, with relevance in diverse fields such as cell biology, microbial ecology, biotechnology, agriculture, and medicine. In this Consensus View, we put forth the status quo and an agreed path forward to reconstruct LECA's gene content.
The mitochondria contain their own genome derived from an alphaproteobacterial endosymbiont. From thousands of protein-coding genes originally encoded by their ancestor, only between 1 and about 70 are encoded on extant mitochondrial genomes (mitogenomes). Thanks to a dramatically increasing number of sequenced and annotated mitogenomes a coherent picture of why some genes were lost, or relocated to the nucleus, is emerging. In this review, we describe the characteristics of mitochondria-to-nucleus gene transfer and the resulting varied content of mitogenomes across eukaryotes. We introduce a 'burst-upon-drift' model to best explain nuclear-mitochondrial population genetics with flares of transfer due to genetic drift.
- Klíčová slova
- CoRR hypothesis, Endosymbiont gene transfer, Evolutionary cell biology, Mitochondrial DNA, Mitochondrial evolution, Mitochondrial mutation rates,
- MeSH
- Eukaryota genetika MeSH
- fylogeneze MeSH
- genom mitochondriální * MeSH
- mitochondrie genetika MeSH
- molekulární evoluce MeSH
- sekvence nukleotidů MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
