Five trisubstituted quinazolones and eight trisubstituted quinazoline-4-thiones have been tested for antibacterial effects by a microdilution method. Four derivatives exerted a significant effect on E. coli, P. aeruginosa, S. aureus and B. subtilis (IC50 < 100 mg/L). In the bacterium P. aeruginosa six quinazolines showed a higher antibacterial effect than ampicillin. The most sensitive to the effects of the quinazolines was S. aureus; a concentration of 100 mg/L of six derivatives induced a bacteriostatic effect on S. aureus. The quinazoline-4-thiones were generally more active than the quinazolones. All the tested concentrations of the four most effective quinazolines influenced the specific growth rate.

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Bacillus subtilis drug effects   MeSH
• Bacteria drug effects   growth & development   MeSH
• Quinazolines chemistry   pharmacology   MeSH
• Escherichia coli drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Staphylococcus aureus drug effects   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Comparative Study MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Quinazolines MeSH

Several dicarbonyl and tricarbonyl sugars were prepared by the use of fungal enzymes and the antimicrobial effects of their N,N-diphenylhydrazine derivatives were tested. G+ bacteria were more sensitive than G- bacteria especially in the group of disubstituted compounds. Peracetyled derivatives were not active. No inhibition of yeast growth was found.

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Bacillus subtilis drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Phenylhydrazines metabolism   pharmacology   MeSH
• Ketoses metabolism   pharmacology   MeSH
• Microbial Sensitivity Tests MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Phenylhydrazines MeSH
• Ketoses MeSH

Antibacterial, antifungal and antiprotozoal effects of nine mono- and bishydrazones of glycolaldehyde, glyoxal, methoxyacetaldehyde and glutaraldehyde were studied using eight model organisms. It was found that bishydrazones are much more efficient antimicrobial agents than monohydrazones in the case of all model microorganisms.

• MeSH
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents pharmacology   MeSH
• Bacillus drug effects   MeSH
• Biotransformation MeSH
• Candida albicans drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Phenylhydrazines biosynthesis   metabolism   MeSH
• Hydrazones metabolism   pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Saccharomyces cerevisiae drug effects   MeSH
• Staphylococcus aureus drug effects   MeSH
• Trichomonas vaginalis drug effects   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents MeSH
• Phenylhydrazines MeSH
• Hydrazones MeSH

Antiprotozoal effects of hydrazones derived from compounds with 1 to 4 carbon atoms were studied on the model organism Trichomonas vaginalis isolated from a female patient with acute urogenital trichomoniasis.

• MeSH
• Antiprotozoal Agents pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Metronidazole pharmacology   MeSH
• Trichomonas vaginalis drug effects   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Antiprotozoal Agents MeSH
• Hydrazones MeSH
• Metronidazole MeSH

The antimicrobial effect of 14 sugar osazones and anhydro sugars was studied with model strains of Micrococcus luteus, Bacillus licheniformis, Escherichia coli and strains Staphylococcus aureus and Pseudomonas aeruginosa isolated from clinical material. The relationship between the structure of these compounds, their solubility in water and 1-octanol and antimicrobial effect was investigated.

• MeSH
• Bacillus drug effects   MeSH
• Bacteria drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Hexoses pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Solubility MeSH
• Staphylococcus aureus drug effects   MeSH
• Structure-Activity Relationship MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Hexoses MeSH
• Hydrazones MeSH

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Bacillus drug effects   MeSH
• Chemical Phenomena MeSH
• Chemistry MeSH
• Escherichia coli drug effects   MeSH
• Hydrazones pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Monosaccharides pharmacology   MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Hydrazones MeSH
• Monosaccharides MeSH