The effect of ethidium bromide on the growth of a yeast mutant with an impaired mitochrondrial translocation system of adenine nucleotides (op-1 mutant) was investigated. It was found that the op-1 mutant stops growing both under growing and non-growing conditions after treatment with ethidium bromide and that the growth cannot be restored by adding low-molecular compounds to the growth medium. It was the aim of the experiments to clarify whether the cessation of growth of the op-1 mutant after induction of the rho- mutation can be simulated by inhibitors phenotypically changing the mitochondrial function. It appears likely that the op-1 mutant stops growing only after the rho- mutation has been induced, because the phenotypic simulation of the rho- mutation does not lead the cessation of growth of the op-1 mutant.

• MeSH
• adeninnukleotidy metabolismus   MeSH
• antibakteriální látky farmakologie   MeSH
• buněčné dělení MeSH
• ethidium farmakologie   MeSH
• kultivační média MeSH
• kvasinky účinky léků   růst a vývoj   metabolismus   MeSH
• mitochondrie metabolismus   MeSH
• mutace * MeSH
• mutageny MeSH
• spotřeba kyslíku MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• adeninnukleotidy MeSH
• antibakteriální látky MeSH
• ethidium MeSH
• kultivační média MeSH
• mutageny MeSH