Childbirth is a challenging event that can lead to long-term consequences such as prolapse or incontinence. While computational models are widely used to mimic vaginal delivery, their integration into clinical practice is hindered by time constraints. The primary goal of this study is to introduce an artificial intelligence pipeline that leverages patient-specific surrogate modeling to predict pelvic floor injuries during vaginal delivery. A finite element-based machine learning approach was implemented to generate a dataset with information from finite element simulations. Thousands of childbirth simulations were conducted, varying the dimensions of the pelvic floor muscles and the mechanical properties used for their characterization. Additionally, a mesh morphing algorithm was developed to obtain patient-specific models. Machine learning models, specifically tree-based algorithms such as Random Forest (RF) and Extreme Gradient Boosting, as well as Artificial Neural Networks, were trained to predict the nodal coordinates of nodes within the pelvic floor, aiming to predict the muscle stretch during a critical interval. The results indicate that the RF model performs best, with a mean absolute error (MAE) of 0.086 mm and a mean absolute percentage error of 0.38%. Overall, more than 80% of the nodes have an error smaller than 0.1 mm. The MAE for the calculated stretch is equal to 0.0011. The implemented pipeline allows loading the trained model and making predictions in less than 11 s. This work demonstrates the feasibility of implementing a machine learning framework in clinical practice to predict potential maternal injuries and assist in medical-decision making.

• Klíčová slova
• Finite element simulations, Machine learning, Mesh morphing, Pelvic floor stretch, Real-time biomechanics, Vaginal delivery,
• MeSH
• algoritmy MeSH
• analýza metodou konečných prvků * MeSH
• biomechanika MeSH
• lidé MeSH
• mechanické jevy MeSH
• pánevní dno * fyziologie   MeSH
• počítačové modelování podle konkrétního pacienta MeSH
• strojové učení MeSH
• těhotenství MeSH
• vedení porodu * MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND AND OBJECTIVE: The prevalence of pelvic floor muscle injuries induced by childbirth is higher than 23 % in the general women population. Such injuries can lead to prolapses and other pathologies in future female life. Leveraging computational biomechanics, the study implements an advanced female pelvic floor model for computing the maximum pelvic muscle strain, which serves as an injury risk indicator. The design of experiment method, abbreviated as DoE, is used to compute the maximum strain for boundary values of bony pelvis dimensions, namely the anterior-posterior diameter (abbreviated as APD) and the transverse diameter (abbreviated as TD). This is done in combination with small, medium and large percentiles of fetal head circumference (abbreviated as HC). METHODS: We utilized a previously developed finite element model of a female pelvic floor, as a reference, and enhanced it with new features, including a more detailed tissue geometry and advanced constitutive material models. The APD and TD dimensions were sourced from the set of MRI of 64 nulliparous women. This data was used to estimate the boundary dimensions of the female bony pelvis, combining both small and large values of APD and TD. Together with the 10th and the 95th percentiles for HC, a three-dimensional domain was constructed to assess the maximum pelvic muscle strain. In boundary cases, the maximum pelvic muscle strain was computed across 8 full-factorial design models (each situated at one corner of the domain, thereby combining the minimum and the maximum values of APD, TD and HC). This was done to define a response surface that predicts the maximum pelvic muscle strain within the domain. The accuracy of this response surface prediction was validated using 15 additional intermediate design models. These models were placed at the center of the domain (1 point), the centres of the domain boundary surfaces (6 points), and midway along each domain boundary edge (8 points). RESULTS: The maximum strain results for 8 combinations of APD, TD, and HC were employed to construct a linear response surface as a function of APD, TD, and HC. Tests at an additional 19 domain points served to evaluate the efficiency of the response surface prediction. The response surface demonstrated strong predictability, with an absolute average error of 1.52 %, an absolute median error of 1.52 %, and an absolute maximum error of 11.11 %. HC emerged as the most influencing dimension, accounting for 16 % of influence. CONCLUSIONS: The reference finite element pelvic floor model was scaled to 8 full-factorial female-specific pelvic floor models, which represent the combination of boundary values for APD, TD, and HC. The maximum pelvic floor muscle strain from these 8 models was used to design a response surface. When implementing the DoE approach to construct the response, there was consistent predictability for the maximum perineal muscle strain, as validated by the additional 19 intermediate design models. As a result, the response surface methodology can serve as an initial predictor for potential childbirth-induced pelvic floor muscle injury.

• Klíčová slova
• Childbirth, Computational biomechanics, Design of experiment, Injury,
• MeSH
• kosterní svaly diagnostické zobrazování   MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• pánevní dno diagnostické zobrazování   fyziologie   MeSH
• porod * fyziologie   MeSH
• těhotenství MeSH
• vedení porodu * MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

INTRODUCTION AND HYPOTHESIS: Several studies have assessed birth-related deformations of the levator ani muscle (LAM) and perineum on models that depicted these elements in isolation. The main aim of this study was to develop a complex female pelvic floor computational model using the finite element method to evaluate points and timing of maximum stress at the LAM and perineum in relation to the birth process. METHODS: A three-dimensional computational model of the female pelvic floor was created and used to simulate vaginal birth based on data from previously described real-life MRI scans. We developed three models: model A (LAM without perineum); model B (perineum without LAM); model C (a combined model with both structures). RESULTS: The maximum stress in the LAM was achieved when the vertex was 9 cm below the ischial spines and measured 37.3 MPa in model A and 88.7 MPa in model C. The maximum stress in the perineum occurred at the time of distension by the suboocipito-frontal diameter and reached 86.7 MPa and 119.6 MPa in models B and C, respectively, while the stress in the posterior fourchette caused by the suboccipito-bregmatic diameter measured 36.9 MPa for model B and 39.8 MPa for model C. CONCLUSIONS: Including perineal structures in a computational birth model simulation affects the level of stress at the LAM. The maximum stress at the LAM and perineum seems to occur when the head is lower than previously anticipated.

• Klíčová slova
• Birth, Delivery, Levator, Modeling, Muscle, Partum, Perineal, Stress, Tension,
• MeSH
• analýza metodou konečných prvků MeSH
• lidé MeSH
• pánevní dno * diagnostické zobrazování   MeSH
• perineum MeSH
• těhotenství MeSH
• vedení porodu * MeSH
• zubní porcelán MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• finesse MeSH Prohlížeč
• zubní porcelán MeSH

Current industrial trends bring new challenges in energy absorbing systems. Polymer materials as the traditional packaging materials seem to be promising due to their low weight, structure, and production price. Based on the review, the linear low-density polyethylene (LLDPE) material was identified as the most promising material for absorbing impact energy. The current paper addresses the identification of the material parameters and the development of a constitutive material model to be used in future designs by virtual prototyping. The paper deals with the experimental measurement of the stress-strain relations of linear low-density polyethylene under static and dynamic loading. The quasi-static measurement was realized in two perpendicular principal directions and was supplemented by a test measurement in the 45° direction, i.e., exactly between the principal directions. The quasi-static stress-strain curves were analyzed as an initial step for dynamic strain rate-dependent material behavior. The dynamic response was tested in a drop tower using a spherical impactor hitting a flat material multi-layered specimen at two different energy levels. The strain rate-dependent material model was identified by optimizing the static material response obtained in the dynamic experiments. The material model was validated by the virtual reconstruction of the experiments and by comparing the numerical results to the experimental ones.

• Klíčová slova
• LLDPE, constitutive material model, impact energy absorption, material parameter identification, quasi-static and dynamic experimental tests, simulation, validation,
• Publikační typ
• časopisecké články MeSH

INTRODUCTION AND HYPOTHESIS: During vaginal delivery, the levator ani muscle (LAM) undergoes severe deformation. This stress can lead to stretch-related LAM injuries. The objective of this study was to develop a sophisticated MRI-based model to simulate changes in the LAM during vaginal delivery. METHODS: A 3D finite element model of the female pelvic floor and fetal head was developed. The model geometry was based on MRI data from a nulliparous woman and 1-day-old neonate. Material parameters were estimated using uniaxial test data from the literature and by least-square minimization method. The boundary conditions reflected all anatomical constraints and supports. A simulation of vaginal delivery with regard to the cardinal movements of labor was then performed. RESULTS: The mean stress values in the iliococcygeus portion of the LAM during fetal head extension were 4.91-7.93 MPa. The highest stress values were induced in the pubovisceral and puborectal LAM portions (mean 27.46 MPa) at the outset of fetal head extension. The last LAM subdivision engaged in the changes in stress was the posteromedial section of the puborectal muscle. The mean stress values were 16.89 MPa at the end of fetal head extension. The LAM was elongated by nearly 2.5 times from its initial resting position. CONCLUSIONS: The cardinal movements of labor significantly affect the subsequent heterogeneous stress distribution in the LAM. The absolute stress values were highest in portions of the muscle that arise from the pubic bone. These areas are at the highest risk for muscle injuries with long-term complications.

• Klíčová slova
• Levator ani muscle, MRI modeling, Vaginal delivery,
• MeSH
• analýza metodou konečných prvků * MeSH
• anatomické modely * MeSH
• biomechanika MeSH
• distorze a distenze etiologie   MeSH
• dospělí MeSH
• hlava anatomie a histologie   MeSH
• kosterní svaly zranění   MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• novorozenec MeSH
• pánevní dno anatomie a histologie   diagnostické zobrazování   fyziologie   MeSH
• plod anatomie a histologie   MeSH
• pružnost MeSH
• těhotenství MeSH
• vedení porodu škodlivé účinky   MeSH
• zobrazování trojrozměrné metody   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

INTRODUCTION AND HYPOTHESIS: Comparison of the modifications of the Viennese method of manual perineal protection (VMPP) and hands-off delivery techniques by applying basic principles of mechanics with assessments of tensions within perineal structures using a novel biomechanical model of the perineum. Evaluation of the role of the precise placements of the accoucheur's posterior (dominant) thumb and index finger in perineal tissue tension when performing a modified Viennese method of MPP. METHODS: We carried out an experimental study on a biomechanical model of the perineum at NTIS (New Technologies for Information Society, Pilsen, Czech Republic). Hands-off and 38 variations of VMPP were simulated during vaginal delivery with the finite element model imitating a clinical lithotomy position. RESULTS: The main outcome measures were quantity and extent of strain/tension throughout the perineal body during vaginal delivery. Stress distribution between modifications of VMPP showed a wide variation in peak perineal tension from 72 to 102 % compared with 100 % for the "hands-off" technique. Extent of reduction depended on the extent of finger movement across a horizontal, transverse x-axis, and on final finger position on a vertical, antero-posterior y-axis. The most effective modification of VMPP was initial position of fingers 12 cm apart (x = ±6) on the x-axis, 2 cm anteriorly from the posterior fourchette (y = +2) on the y-axis with 1cm movement of both finger and thumb toward the midline on the x-axis (Δx = 1) with no movement on the y-axis (Δy = 0). CONCLUSIONS: In a biomechanical assessment with simulation of vaginal delivery, exact placement of fingertips on the perineal skin, together with their co-ordinated movement, plays an important role in the extent of reduction of perineal tension.

• MeSH
• biologické modely MeSH
• biomechanika MeSH
• lidé MeSH
• perineum zranění   MeSH
• počítačová simulace MeSH
• porod MeSH
• prsty ruky * MeSH
• rány a poranění prevence a kontrola   MeSH
• vedení porodu metody   MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH