- MeSH
- aminofylin farmakologie MeSH
- bronchodilatancia farmakologie MeSH
- inhibitory fosfodiesteras farmakologie MeSH
- králíci MeSH
- respirační sliznice účinky léků ultrastruktura MeSH
- trachea účinky léků ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- aminofylin MeSH
- bronchodilatancia MeSH
- inhibitory fosfodiesteras MeSH
The ultrastructure of the rabbit tracheal epithelium was studied 30 minutes after intratracheal administration of two puffs of salbutamol and ipratropium bromide, respectively. The injury to the tracheal epithelium due to the treatment with both bronchospasmolytic drugs was considered moderate to severe. In both experimental groups, the degree of goblet cells' stimulation did not differ significantly, the ciliated cells were less damaged compared with the goblet ones and the morphological signs of the impaired self-cleaning ability were revealed.
- MeSH
- agonisté adrenergních beta-receptorů toxicita MeSH
- albuterol toxicita MeSH
- epitel účinky léků ultrastruktura MeSH
- ipratropium toxicita MeSH
- králíci MeSH
- parasympatolytika toxicita MeSH
- trachea účinky léků ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- agonisté adrenergních beta-receptorů MeSH
- albuterol MeSH
- ipratropium MeSH
- parasympatolytika MeSH
The authors investigated 10 men aged 30 to 60 years who developed repeatedly attacks of atrial fibrillation. In all patients previous alcohol consumption was recorded in the case-history. In none of the patients organic heart disease was detected. In previous experiments the authors induced by alcohol administration to rats in the tracheal cells and paratracheal myelinated nerves an increased occurrence of lamellar bodies which is consistent with data in the literature which confirmed the presence of lamellar bodies in the human heart muscle in idiopathic cardiomyopathy. The authors assume therefore that alcohol induced increased presence of lamellar bodies in the myocardium which are formed during dystrophic changes, in particular from mitochondria, can lead due to reduced energy release to impaired conduction of excitation in the myocardium. This condition may be enhanced also by impaired calcium metabolism in alcoholic dystrophy.
- MeSH
- alkoholická kardiomyopatie komplikace patologie MeSH
- dospělí MeSH
- ethanol toxicita MeSH
- fibrilace síní etiologie patologie MeSH
- krysa rodu Rattus MeSH
- lidé středního věku MeSH
- lidé MeSH
- nervová vlákna myelinizovaná účinky léků ultrastruktura MeSH
- trachea účinky léků inervace ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- krysa rodu Rattus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- ethanol MeSH
The ciliostatic activity of exo- and endometabolites of 243 filamentous fungal strains was evaluated by in vitro bioassay using tracheal organ cultures of 1-d-old chicks. Chloroform-extractable metabolites produced in the cultivation medium (25 degrees C/10 d) by 30 out of 72 (41%) investigated strains displayed the ciliostatic activity as did metabolites from the biomass of the spores and the mycelium of 46 other strains (26%). This result could contribute to the clarification of the correlation between fungi and respiratory disorders in some working places and in damp dwellings.
- MeSH
- chemická deprese MeSH
- chloroform MeSH
- cilie účinky léků fyziologie MeSH
- epitel účinky léků patofyziologie ultrastruktura MeSH
- houby chemie MeSH
- kur domácí MeSH
- lidé MeSH
- mykotoxiny izolace a purifikace farmakologie MeSH
- pohyb MeSH
- rozpouštědla MeSH
- syndrom nezdravých budov mikrobiologie MeSH
- trachea účinky léků patofyziologie ultrastruktura MeSH
- vystavení vlivu životního prostředí MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- chloroform MeSH
- mykotoxiny MeSH
- rozpouštědla MeSH
The ultrastructure of rabbit tracheal epithelium was studied 20 min after injection of 0.04 and 0.5 mg of atropin. The tracheae were lined with altered ciliated pseudostratified columnar epithelium. The degree of damage to the epithelial cells was dose dependent. The injury to the tracheal epithelium due to treatment with 0.04 mg of atropin was considered mild. The administration of the higher dose of atropin caused moderately severe epithelial damage. Both experimental groups exhibited morphological signs of impaired self-cleaning ability.
- MeSH
- atropin aplikace a dávkování farmakologie MeSH
- časové faktory MeSH
- elektronová mikroskopie MeSH
- epitel účinky léků ultrastruktura MeSH
- epitelové buňky MeSH
- králíci MeSH
- trachea cytologie účinky léků ultrastruktura MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- atropin MeSH
An abnormally high occurrence of malformed kinocilia containing axonemes with different number or arrangement of microtubules compared with the typical 9+2 pattern of motile cilia was encountered in the tracheal epithelium of one clinically healthy rabbit. The malformed cilia amounted to 6.87% of all kinocilia. Individual types of ciliary malformations were further classified. The frequency of ciliary malformations was compared with that in all other rabbits the ciliary border of which has been quantitatively evaluated in our laboratory. Using Grubbs test the extremely low probability of occurrence of such a high number of malformed kinocilia in the rabbits' population was verified. The studied rabbit suffered from a mild form of the immotile cilia syndrome, but the loss of less than 10% of moving cilia did not lead to the expression of the clinical signs of the impaired function of cilia in the organism.
- MeSH
- cilie ultrastruktura MeSH
- epitel ultrastruktura MeSH
- králíci anatomie a histologie MeSH
- trachea ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- králíci anatomie a histologie MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The ultrastructure of the tracheal epithelium after the application of 1 ml of Hexabrix (a hexaiodated contrast agent for tracheobronchography) into the airways was studied. Severely altered pseudostratified columnar epithelium was found in the trachea. Eighty-one +/- 5% of the goblet cells had been stimulated to discharged mucus. Forty-three +/- 3% of them were completely exhausted and had degenerated. The ciliated cells displayed marked signs of pathological alteration up to vacuolar degeneration. The ciliary border above the epithelium was severely damaged. The mean number of cilia per micron 2 fell to 3.3 +/- 0.5, but the proportion of intact cilia did not drop below 95%. As morphological signs of impaired self-cleaning ability of the airway epithelium, a large amount of inspissated mucus and numerous bacteria were found in the area of the impaired ciliary border. Coarse grained contrast substance of supreme electron density was intermingled with the condensed mucus. The most pronounced damage to the cells was observed at the sites of direct contact of the contrast agent with the cell membranes.
- MeSH
- cilie účinky léků ultrastruktura MeSH
- epitel účinky léků ultrastruktura MeSH
- kontrastní látky MeSH
- králíci MeSH
- kyselina joxaglová farmakologie MeSH
- trachea účinky léků ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kontrastní látky MeSH
- kyselina joxaglová MeSH
Serious damage to the tracheal epithelium due to bronchoalveolar lavage (BAL) was recorded. Immediately after BAL 99 +/- 2% of goblet cells were exhausted and degenerated. Their regeneration began 24 h after BAL resulting in hyperplasia of goblet cells with the formation of endoepithelial mucous glands. The most pronounced injury to the ciliated cells was apparent 2 h after BAL. BAL markedly impaired the ciliary border. The mean number of cilia/microns 2 fell to 1.5 +/- 0.3/microns 2, then gradually rose to 7.5 +/- 0.5/microns 2 (controls 9.7 +/- 0.5/microns 2). The morphological signs of impairment of the self-cleaning ability of the epithelium were the most pronounced after 24 h and were still present at the end of the experiment.
- MeSH
- bronchoalveolární lavážní tekutina * MeSH
- časové faktory MeSH
- epitel ultrastruktura MeSH
- králíci MeSH
- trachea ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
There are considerable differences in the reactivity of tracheobronchial muscles to bronchoconstricting substances in guinea pigs and rats. The aim of the present investigation was to assess whether these functional differences have a morphological or biochemical background. Therefore specimens of this tissue were taken for histological and biochemical examination i. e. assessment of cyclic nucleotides. While in the nucleotide content no interspecific differences were found, there were some morphological differences which may explain the less marked response of smooth muscles of the rat to bronchoconstricting stimuli.
- MeSH
- bronchy účinky léků metabolismus ultrastruktura MeSH
- druhová specificita MeSH
- hladké svalstvo účinky léků metabolismus ultrastruktura MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- morčata MeSH
- svalová kontrakce účinky léků MeSH
- techniky in vitro MeSH
- trachea účinky léků metabolismus ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- morčata MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- srovnávací studie MeSH
