A complex toxicological study was carried out in relation to the hygienic standardization of the fungicide preparation Ridomil, whose forthcoming production in this country will be under the name Metalaxyl. The study was performed on sexually mature white rats of both sexes, at oral, dermal and inhalation exposure, acute, subacute and chronic experiments, according to the Bulgarian State Standard. Besides the routine toxicological studies were carried also studies for establishing the long-term effects of the preparation (gonadotropic, embryotoxic and teratogenic, cardiovascular). The results from the study permitted the Agromet preparation to be put in III class--moderately toxic according to limiting index LD50 oral. On the basis of data from the authors study on the general toxicity and long-term effects of Metalaxyl a temporary MAC 4 mg/m3 was proposed.

• MeSH
• alanin analogy a deriváty   farmakokinetika   toxicita   MeSH
• embryo savčí účinky léků   MeSH
• gonády účinky léků   MeSH
• inbrední kmeny potkanů MeSH
• kardiovaskulární systém účinky léků   MeSH
• krysa rodu Rattus MeSH
• LD50 MeSH
• průmyslové fungicidy toxicita   MeSH
• teratogeny MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• alanin MeSH
• metalaxyl MeSH Prohlížeč
• průmyslové fungicidy MeSH
• teratogeny MeSH

The azido derivatives of alcohols (3-azido-1,2-propandiol and 1,3-diazido-2-propanol) and monosaccharides (6-azido-6-deoxy-beta-D-glucose and 6-azido-6-deoxy-beta-D-galactose), as well as the proximal mutagenic product of sodium azide metabolism beta-azido-L-alanine, exhibited a high mutagenic activity in a higher plant Arabidopsis thaliana and in Salmonella typhimurium. In contrast, 11 N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines (adenine, thymine, uracil, cytosine, 2-amino-6-chloropurine, 6-chloropurine, 2,6-diaminopurine, 6-methylthiopurine, 4-O-methylthymine, 4-O-methyluracil and 7-deaza-8-azaadenine) were mutagenic in the Ames assay but ineffective in the Arabidopsis mutagenicity assay.

• MeSH
• 1-propanol toxicita   MeSH
• alanin analogy a deriváty   toxicita   MeSH
• alkoholy toxicita   MeSH
• azidy toxicita   MeSH
• deoxyglukosa analogy a deriváty   toxicita   MeSH
• fukosa analogy a deriváty   toxicita   MeSH
• monosacharidy toxicita   MeSH
• mutace * MeSH
• propylenglykoly toxicita   MeSH
• puriny toxicita   MeSH
• pyrimidiny toxicita   MeSH
• rostliny genetika   MeSH
• Salmonella typhimurium genetika   MeSH
• testy genotoxicity * MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• 1-propanol MeSH
• alanin MeSH
• alkoholy MeSH
• azidoalanine MeSH Prohlížeč
• azidy MeSH
• deoxyglukosa MeSH
• fukosa MeSH
• monosacharidy MeSH
• propylenglykoly MeSH
• puriny MeSH
• pyrimidiny MeSH