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17 záznamů v PubMed Filtry

Článek

Exprese S-100 proteinu v osteogenních nádorech a tumoriformních osteoplastických lézích
[S-100 protein positivity in osteogenic tumours and tumour-like bone forming lesions]

Ceskoslovenska patologie. 2008 Jul ; 44 (3) : 59-61.

Cesk Patol
ISSN 1210-7875
Zdroj

Various osteogenic tumours and bone producing tumour-like lesions of bone were examined for S-100 protein using the immunostaining methods. The positive reaction for S-100 protein of some bone cells was detected not only in osteoblastic osteosarcomas and osteoblastomas, but also in osteoplastic reactive lesions, fibrous dysplasia, Paget's disease and in the tissue of the bony callus. The positive reaction for osteocalcin in these cells showed, that they may be of osteoblastic and osteocytic lineage. The S-100 protein positive bone cells have to be differentiated from chondrocytes persisting in new-formed bone trabecullae. On the one hand S-100 protein positive osteocytes and osteoblasts may represent transient form of osteocytes histogenetically related to chondrocytes, but we were not able to prove such suggestion. Therefore, S-100 protein positivity can be caused by polyclonal character of the used antibody, that is a mixture of three antibodies, S-100 A1, A6 and anti B2. The specificity of these three components differs depending on the histogenesis of cells and their functional status. Such explanation is supported by the results of our study, because we also observed intense positivity of bone cells in the reaction with monoclonal antibody against S-100A6. In contrast, no staining of bone cells was detected with monoclonal antibodies against S-100 A1 and B2.

MeSH
heterotopická osifikace metabolismus MeSH
imunohistochemie MeSH
kosti a kostní tkáň chemie MeSH
lidé MeSH
nádory kostí chemie MeSH
nemoci kostí metabolismus MeSH
proteiny S100 analýza MeSH
Check Tag
lidé MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
Názvy látek
proteiny S100 MeSH

Článek

Selected markers of bone biochemistry

Advances in clinical chemistry. 2000 ; 35 () : 255-94.

Adv Clin Chem
ISSN 0065-2423
Zdroj

MeSH
biologické markery * MeSH
cytokiny metabolismus MeSH
hormony metabolismus MeSH
kosti a kostní tkáň chemie metabolismus fyziologie MeSH
lidé MeSH
nemoci kostí diagnóza metabolismus MeSH
remodelace kosti fyziologie MeSH
reprodukovatelnost výsledků MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
přehledy MeSH
Názvy látek
biologické markery * MeSH
cytokiny MeSH
hormony MeSH

Článek

Oxalóza u nemocných v pravidelném dialyzacním lécení
[Oxalosis in patients on regular dialysis therapy]

Vnitrni lekarstvi. 1992 Jul ; 38 (7) : 701-6.

Vnitr Lek
ISSN 0042-773X
Zdroj

The authors draw attention to the case of a 46-year-old man who developed after three years of regular dialyzation treatment three times a week the first manifestations of acquired generalized oxalosis. The oxalosis was most marked on the skin, skeleton, heart, and kidneys. Oxalosis was confirmed after eight years of dialysis after death by post-mortem and histological examination and microscopic detection of oxalate crystals. The authors recommend that as part of regular dialyzation treatment patients should not be given more than 100 mg ascorbic acid per day. Oxalates are also the end product of degradation of ascorbic acid and high doses may lead also to hyperoxalosis. Moreover deposits in some visceral organs, in particular the heart may cause clinical manifestations. In the authors patients they caused attacks of auricular flutter. Although these clinical manifestations develop only rarely, the latent form of acquired oxalosis is probably more frequent.