A search is presented for the pair production of new heavy resonances, each decaying into a top quark (t) or antiquark and a gluon (g). The analysis uses data recorded with the CMS detector from proton-proton collisions at a center-of-mass energy of 13 Te V at the LHC, corresponding to an integrated luminosity of 138 fb - 1 . Events with one muon or electron, multiple jets, and missing transverse momentum are selected. After using a deep neural network to enrich the data sample with signal-like events, distributions in the scalar sum of the transverse momenta of all reconstructed objects are analyzed in the search for a signal. No significant deviations from the standard model prediction are found. Upper limits at 95% confidence level are set on the product of cross section and branching fraction squared for the pair production of excited top quarks in the t ∗ → tg decay channel. The upper limits range from 120 to 0.8 fb for a t ∗ with spin-1/2 and from 15 to 1.0 fb for a t ∗ with spin-3/2. These correspond to mass exclusion limits up to 1050 and 1700 Ge V for spin-1/2 and spin-3/2 t ∗ particles, respectively. These are the most stringent limits to date on the existence of t ∗ → tg resonances.
- Publikační typ
- časopisecké články MeSH
AIMS: This pilot study aims to present a novel method for quantitatively assessing the decentration of a trifocal intraocular lens (IOL) (Acrysof IQ PanOptix®) relative to three ocular reference points: the visual axis (first Purkinje reflex), the photopic pupil center, and, for the first time, the corneal geometric center. Additionally, the study evaluates the influence of postoperative chord mu, chord alpha, and the distances of the IOL from these reference points on visual outcomes. MATERIALS AND METHODS: This retrospective, observational study included 18 eyes from 12 patients who underwent cataract surgery with PanOptix® IOL implantation. Postoperative IOL positioning was assessed using OPD-Scan III images, applying a novel approach that combines diffuse frontal and retroillumination views. Distances between the IOL center and three ocular reference points, including the corneal geometric center, were measured, and postoperative patient satisfaction was evaluated using the Catquest-9SF survey. Statistical analyses were performed to assess correlations among reference distances, chord measurements, and visual performance. RESULTS: The study found that in 72.2% of cases, the IOL center was closer to the visual axis than to the corneal geometric center. A greater distance between the IOL and the corneal geometric center was associated with an improved near-vision area under the visual acuity defocus curve. However, no significant correlations were found between chord mu or chord alpha and visual outcomes, patient symptoms, or satisfaction. CONCLUSION: This new approach to determining IOL centration proved practical, showing that the PanOptix® IOL tends to remain close to the visual axis over time, aligning with the surgeon's initial placement. No clear associations were found between chord mu, chord alpha, or most IOL distances (except the distance to the corneal geometric center) and visual quality or patient satisfaction. Further studies are needed to confirm these findings and to refine selection criteria for multifocal IOLs to enhance patient satisfaction and visual outcomes.
- Klíčová slova
- IOL decentration, Trifocal intraocular lens, chord alpha, chord mu, corneal geometric center, visual axis,
- MeSH
- extrakce katarakty MeSH
- implantace nitrooční čočky * MeSH
- lidé středního věku MeSH
- lidé MeSH
- multifokální intraokulární čočky MeSH
- nitrooční čočky MeSH
- pilotní projekty MeSH
- posunutí nitrooční čočky patofyziologie diagnostické zobrazování MeSH
- retrospektivní studie MeSH
- senioři MeSH
- spokojenost pacientů MeSH
- zraková ostrost MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
AIMS: To demonstrate the relationship of dependency between the thickness of the retinal nerve fiber layer and the functional sensitivity of the retina in healthy young individuals. We also secondarily investigated the relationship between refractive error and mean retinal thickness in the macula. MATERIAL AND METHODS: The basic cohort contained 30 subjects with an average age of 23.4 ±4.2 years. These were young, generally healthy individuals without serious ocular pathologies. The average value of spherical equivalent in both eyes of all individuals was -1.2 ±2.5 D. We measured the thickness of the retinal nerve fiber layer (RNFL) in the papilla area and the average thickness of the retina in the area of the macula using the device OPKO Spectral OCT SLO Combination Imaging System (Opko Health, USA). We performed a functional examination of the retina within an area up to 30° using a perimeter with a stimulus with a Frequency Doubling Technology (FDT) from the company Humphrey (Carl Ziess Meditec, Inc., Dublin, CA). As a significant variable for comparison, we determined the mean value of retinal sensitivity deviation (MD). RESULTS: In our study, we did not demonstrate a statistically significant relationship between the average thickness of the retinal nerve fiber layer (RNFL) and the average value of retinal functional sensitivity (r = 0.18, p = 0.34) in either right eyes or the left eyes of the examined subjects (r = 0.20, p = 0.29). We also did not find a statistically significant relationship secondarily between the variable called the spherical equivalent of refractive error (SE) and the average retinal thickness in the macula in either the right eyes (r = 0.34, p = 0.06) or the left eyes (r = 0.18, p = 0.32). CONCLUSION: When comparing the average thickness of the nerve fibers in the papilla with the help of OCT examination and the functional sensitivity of the retina measured on an FDT perimeter, we did not find a statistically significant dependence in the group of right eyes or in the group of left eyes. We also achieved a similar result when examining the interdependence of the variables of spherical equivalent of refractive error of the eye and the average thickness of the retina in the macula.
- Klíčová slova
- FDT perimeter, OCT, RNFL, SE, macula, papilla, surgical treatment,
- MeSH
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- nervová vlákna * fyziologie patologie MeSH
- optická koherentní tomografie * MeSH
- refrakční vady patofyziologie MeSH
- retina * diagnostické zobrazování MeSH
- testy zrakového pole MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
AIM: Retinal detachment is an acute sight-threatening condition that requires immediate surgical intervention. The aim of this study is to compare the outcomes of pars plana vitrectomy (PPV) for uncomplicated rhegmatogenous retinal detachment (RRD) between the different types of gases used, the position, and the number of tears. MATERIAL AND METHODS: This is a retrospective non-randomized comparative study of patients with uncomplicated RRD treated at the Department of Ophthalmology from March 2018 to April 2021 using PPV. A total of 494 evaluated eyes were included in the study. The anatomical success of the surgery was monitored with regard to the extent of retinal detachment, the number and position of tears, and the tamponade used. RESULTS: The success rate of retinal reattachment with a single operation was 90.7% (448 eyes), and the final anatomical success rate was 100%. A very weak paired relationship was found between the success of the surgery for tears in the 4-8 hours region and the 9-3 hours region (89.1% vs. 92%). Similarly, no significant differences were observed between procedures using SF6 and C3F8 gases for RRD with a tear in the 4-8 hours region (success rate 93.4% for SF6 vs. 89.1% for C3F8). The average postoperative improvement of best corrected visual acuity was 29.6 ETDRS letters, and a gain of 15 letters was recorded in 55.1% (272 eyes). Overall, the complication rate was very low. CONCLUSION: PPV is a safe and effective method for treating RRD. Extensive experience with this method allows the use of short-acting tamponades in selected patients.
- Klíčová slova
- Pars plana vitrectomy, Retinal detachment, gas tamponade, vitrectomy,
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- odchlípení sítnice * chirurgie MeSH
- perforace sítnice * chirurgie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- vitrektomie * metody MeSH
- výsledek terapie MeSH
- zraková ostrost MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
AIM: The aim of the article is to summarize observations on cytomegalovirus (CMV) anterior uveitis, and in short case reports present cases of patients treated at our Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague. MATERIAL AND METHODS: Retrospective analysis of patients at the Centre for diagnosis and treatment of uveitis from 2003 to 2024. Presentation of our experiences with CMV anterior uveitis confirmed by polymerase chain reaction (PCR) in aqueous humor in case reports. RESULTS: From a cohort of 3844 patients with uveitis, 3 patients were diagnosed with CMV anterior uveitis, confirmed by PCR in the aqueous humor. The clinical presentation was as acute recurrent hypertensive anterior uveitis in all patients, with a switch to chronic form with elevated intraocular pressure (IOP). Despite local anti-inflammatory and antiglaucomatous therapy, there was high recurrence of uveitis with decompensation of IOP when the medication was reduced. Patients underwent antiglaucoma surgery because of persistent high IOP despite maximal local antiglaucomatous therapy. An anterior chamber tap was taken for PCR analysis, with a CMV-positive result. After the initiation of antiviral therapy with local ganciclovir, patients manifested compensated IOP and a pronounced reduction of recurrences of uveitis and progression of glaucoma. CONCLUSIONS: CMV anterior uveitis is a rare pathology in our geographic region, but it is important to consider this etiology in cases of recurrent anterior hypertensive uveitis with a low response to local anti-inflammatory medication. Timely verification of the etiological agent with prompt diagnosis and treatment is essential in order to achieve a favorable prognosis. Long-term, low maintenance doses of antiviral therapy with local ganciclovir for several months reduce relapses of uveitis and lead to compensation of IOP.
- Klíčová slova
- anterior uveitis, cytomegalovirus, ganciclovir, plasmapheresis, secondary glaucoma,
- MeSH
- antivirové látky terapeutické užití MeSH
- cytomegalovirové infekce * diagnóza farmakoterapie komplikace virologie MeSH
- Cytomegalovirus izolace a purifikace genetika MeSH
- dospělí MeSH
- komorová voda virologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- přední uveitida * virologie diagnóza farmakoterapie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antivirové látky MeSH
AIMS: To investigate the concordance between the corneal power determined by various approaches with two tomographers (MS-39® and Galilei G6®) and the clinical history method (CHM) in patients undergoing photorefractive surgery with excimer laser for myopic errors. MATERIAL AND METHODS: Prospective cohort study. Patients undergoing keratorefractive surgery, and having pre- and postoperative keratometries, and tomographies, were included. RESULTS: In 90 eyes, the differences in the power estimated by the CHM and the one determined by four approaches with the corneal tomographers, which included measurements of the posterior cornea, did not show statistically significant differences in their averages. However, the 95% limits of agreement were very wide. After obtaining regression formulas to adjust the values of these four variables, the results of the agreement analysis were similar. CONCLUSION: Although certain values either directly determined or derived from measurements with the Galilei® and MS-39®corneal tomographers, approximated the estimated value of postoperative corneal power according to the CHM, due to the amplitude of their limits of agreement, these calculations must be taken with care, because they may not be accurate in a given eye.
- Klíčová slova
- corneal power, corneal tomography, clinical history method, refractive surgery,
- MeSH
- dospělí MeSH
- fotorefrakční keratektomie MeSH
- lasery excimerové terapeutické užití MeSH
- lidé MeSH
- mladý dospělý MeSH
- myopie * chirurgie patofyziologie diagnostické zobrazování MeSH
- prospektivní studie MeSH
- refrakce oka MeSH
- rohovka * diagnostické zobrazování chirurgie patologie patofyziologie MeSH
- rohovková topografie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Grape pomace, a winemaking byproduct, is nutrient- and polyphenol-rich, but research on its use in beef cattle is limited. This study explored the impact of grape pomace-based complete pellet feed on growth, serum biochemistry, fatty acid profile, and rumen microbiota in beef cattle. Fifteen healthy Simmental cattle were randomly divided into three groups (G0, G15, and G20) and fed a complete pelleted ration containing 0%, 15%, and 20% of grape pomace, respectively, for 60 days. The results showed that the addition of grape pomace to the ration markedly increased the average daily feed intake and average daily weight gain in beef cattle. In terms of biochemistry, the levels of total protein (TP) and albumin (ALB) in the G20 group were higher than in the G0 group (p > 0.05). The levels of oleic acid, linoleic acid, and behenic acid were higher in the G20 group than in the G0 group. Grape pomace had no significant effect on rumen fungal diversity and total volatile fatty acids (TVFAs) in beef cattle. The pH and ammonia nitrogen content in the G15 and G20 groups were significantly higher than that in the G0 group. This indicates that grape pomace can be used as feed raw material for beef cattle.
- Klíčová slova
- beef cattle, fatty acid traits, feed efficiency, non-conventional feed resources, rumen digestive characteristics,
- Publikační typ
- časopisecké články MeSH
Dynamin superfamily proteins mediate mitochondrial fusion in fungi and animals. A new study expands the taxonomic reach of this superfamily and provides insights into the roles these proteins play by investigating MfnL, a family member involved in trypanosomal mitochondrial dynamics. Importantly, MfnL occurs widely in eukaryotes and prokaryotes.
- MeSH
- dynaminy * metabolismus genetika MeSH
- mitochondriální dynamika * fyziologie MeSH
- mitochondriální proteiny metabolismus genetika MeSH
- mitochondrie metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dynaminy * MeSH
- mitochondriální proteiny MeSH
The semi-synthetic cannabinoid hexahydrocannabinol (HHC) has become a highly discussed topic in forensic toxicology since 2022 due to its legal availability at this time and its psychoactive effects. This study aimed to investigate the pharmacokinetics, effects, and immunological detectability of HHC after oral (25 mg HHC fruit gum) and inhalative (three puffs from HHC vape) consumption with three participants per group. Serum (up to 48 h), urine (up to five days), and saliva (up to 48 h) samples were collected at different relevant time points and analyzed by HPLC-MS/MS for (9R)/(9S)-HHC, 11-hydroxy-HHC, and (9R)/(9S)-HHC carboxylic acid with a fully validated method. Additionally, immunological detectability was investigated with three different commercially available tests. To address the psychoactive effects, the subjective "high" feeling (scale 0-10) was monitored and different psychophysical tests (e.g. modified Romberg test, walk and turn) were conducted. Overall, the pharmacokinetics and effects of HHC were comparable to tetrahydrocannabinol (THC). However, the route of administration as well as inter-individual factors played a crucial role regarding maximum concentrations, pharmacokinetic profiles, and psychoactive effects.
- Klíčová slova
- Cannabinoids, Forensic toxicology, Hexahydrocannabinol, Pharmacokinetics, Psychophysical tests,
- MeSH
- agonisté kanabinoidních receptorů farmakokinetika farmakologie MeSH
- aplikace inhalační * MeSH
- aplikace orální * MeSH
- dospělí MeSH
- emoce účinky léků MeSH
- farmakokinetika * MeSH
- imunologické testy MeSH
- kanabinoidy * analýza krev farmakokinetika farmakologie moč MeSH
- kapalinová chromatografie-hmotnostní spektrometrie MeSH
- lidé MeSH
- psychofyziologie * MeSH
- psychotropní léky * analýza krev farmakokinetika farmakologie moč MeSH
- sliny chemie MeSH
- tetrahydrokanabinol farmakokinetika farmakologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- agonisté kanabinoidních receptorů MeSH
- kanabinoidy * MeSH
- psychotropní léky * MeSH
- tetrahydrokanabinol MeSH
