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Detection of proteoglycans in biological fluids is a perspective method for the evaluation of the degree of catabolic processes in articular cartilage. The demand of accuracy and specificity of detection of substructures of the degradation products of the cartilaginous matrix, with the perspective of routine large scale examinations, restricts available possible methods practically only to the use of immunochemical methods. In the present investigation in the inhibitory ELISA test polyclonal antibodies with a double specificity in relation to basic structures of the cartilage--proteoglycans--were used. The highest concentrations of degradation products of proteoglycans in punctates of synovial fluid were found in diseases where the clinical picture is dominated by repeated attacks of the joints with longer remission periods, and where the attack is stimulated, usually by stimuli of an intermittent systemic or exogenous character (gout, reactive arthritis incl. Reiter's syndrome, Lyme disease).

Článek

Prevalence and distribution of cartilage damage at the metacarpal head level in rheumatoid arthritis and osteoarthritis: an ultrasound study

The prevalence and distribution of cartilage damage were analysed. ...

Rheumatology (Oxford, England). 2019 Jul 01 ; 58 (7) : 1206-1213.

Rheumatology (Oxford)
ISSN 1462-0332 | 1462-0324
Zdroj

OBJECTIVES: To determine the prevalence and distribution of US-detected qualitative cartilage damage at metacarpal heads of patients with RA and hand OA. METHODS: Fifty-two RA patients and 34 patients with hand OA were enrolled. US examination of the metacarpal head cartilage from the II to V finger of both hands was performed. A total of 414 MCP joints in RA and 266 MCP joints in OA patients were scanned with a linear probe up to 22 MHz. Qualitative assessments using a previously described scoring system for cartilage damage were performed. The prevalence and distribution of cartilage damage were analysed. Multivariate regression analysis was used to determine the predictive value of age, gender, BMI, disease duration and the presence of RF and anti-CCP antibodies for US-detected cartilage damage. RESULTS: The metacarpal head cartilage was positive for cartilage damage in 35.7% (148/414) of MCP joints in RA and in 43.6% (116/266) of MCP joints in OA patients. In RA, the hyaline cartilage of the II and III metacarpal heads (bilaterally) was the most frequently affected. In OA, cartilage damage was more homogeneously distributed in all MCP joints. Multivariate regression analysis showed that age and disease duration, but not gender, BMI or autoantibody status, were independent predictors of US-detected cartilage damage in RA. CONCLUSION: Cartilage damage was found in more than one-third of the MCP joints in both RA and OA patients, and in RA patients, the II and III MCP joints were the most damaged.

Klíčová slova
OA, RA, cartilage damage, ultrasonography,
MeSH
antirevmatika terapeutické užití MeSH
autoprotilátky krev MeSH
dospělí MeSH
kloubní chrupavka diagnostické zobrazování MeSH
lidé středního věku MeSH
lidé MeSH
metakarpofalangeální kloub diagnostické zobrazování MeSH
nemoci chrupavky diagnostické zobrazování etiologie MeSH
osteoartróza komplikace diagnostické zobrazování farmakoterapie MeSH
rentgendiagnostika MeSH
reprodukovatelnost výsledků MeSH
revmatoidní artritida komplikace diagnostické zobrazování farmakoterapie MeSH
senioři MeSH
sexuální faktory MeSH
stupeň závažnosti nemoci MeSH
ultrasonografie MeSH
věkové faktory MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH
práce podpořená grantem MeSH
Názvy látek
antirevmatika MeSH
autoprotilátky MeSH

Článek

Fluorescent advanced glycation end products in the detection of factual stages of cartilage degeneration

At the initial phase of surgery, a sample of cartilage was taken for laboratory examination. ...

Physiological research. 2007 ; 56 (2) : 235-242. [epub] 20060323

Physiol Res
ISSN 0862-8408
Zdroj

Patients treated for knee disorders were included in this study. They were examined clinically (Lequesne and Tegner scores) and by standard X-ray investigation. Patients underwent a surgical procedure, either arthroscopy or knee replacement. At the initial phase of surgery, a sample of cartilage was taken for laboratory examination. Progression of the disorder and the clinical examination was correlated with the actual state of the cartilage using a novel fluorescence approach. The intrinsic fluorescence of cartilages was shown as a suitable and sensitive method for detection of the actual state of cartilages because the correlation with X-ray examination and clinical status was found. Intrinsic fluorescence properties of cartilages from patients with chondropathy and osteoarthritis were described and found to be age-dependent. We also observed a higher concentration of advanced glycation end products due to inflammatory and/or degenerative processes in the cartilage. In addition, acute pathological changes due to diseases such as meniscal lesions or anterior cruciate ligament rupture caused a significant increase of formation of advanced glycation end products even in the group of young patients. In fact, such an observation could be crucial and important for the detection of knee conditions suspected of early meniscal and/or ACL lesions especially among young patients.

Článek

Study on familial outbreaks of alkaptonuria and articular chondrocalcinosis

Bratislavske lekarske listy. 1962 Aug 15 ; 42 () : 129-35.

Bratisl Lek Listy
ISSN 0006-9248
Zdroj

Klíčová slova
ALKAPTONURIA *, CALCINOSIS *, CARTILAGE *, JOINT DISEASES *,
MeSH
alkaptonurie * MeSH
chondrokalcinóza * MeSH
chrupavka * MeSH
epidemický výskyt choroby * MeSH
kalcinóza * MeSH
lidé MeSH
nemoci kloubů * MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH

Článek

Nové moznosti v lécbe poúrazových defektů kloubní chrupavky
[New options for management of posttraumatic articular cartilage defects]

Articular cartilage trauma, in particular due to its poor healing potential remains a complicated problem ...

Rozhledy v chirurgii. 2008 Jan ; 87 (1) : 42-5.

Rozhl Chir
ISSN 0035-9351
Zdroj

Articular cartilage trauma, in particular due to its poor healing potential remains a complicated problem in both the adult and paediatric traumatology and orthopedics. In older patients, total endoprosthesis of the joint is a method of choice, however, in younger patients, the situation remains more complicated. In case of osteochondral lesions (arthrosis, chondral fractures. osteochoodrosis dissecns) the ideal management should result in complete recovery of the hyaline cartilage on the traumatized joint surface. Contemporary medicine uses some therapeutic procedures resulting in partial recovery of the articular cartilage structure at the lesion site and several techniques of excisionining the articular surface's injured part and of transplantations of biological grafts. Regarding the above first approach, abrasive methods (micro fractures, small drill holes), which are expected to result in recovery of the articular cartilage through progenitor cells that migrate from the bone marrow to the defect site following subchondral fracturing. In case the injury is managed early, the osteochondral fragment may be fixed and the articular congruence be recovered. Mosaicoplasty using osteochondral auto grafts or other autologous grafts, or more recently using transplantations of autologous chond rocytes, which seem to have a major potential in the hyaline cartilage healing process. However, methodology of the transplant retention at the defect site remains a problem. Furthermore, the use of mesenchymal stem cells, so far in the experimental phase, appears prospective. Pivotal articular cartilage treatment research activities have progressed to a level of searching for a suitable scaffold of perfect qualities. This is the task for cooperation with bioengineering. requiring provision of the most exact differentiation protocol for hyline cartilage producing mesenchymal stem cells (MSCs).

Publikováno

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CARTILAGE/diseases Dotaz Zobrazit nápovědu

CARTILAGE/diseases Dotaz Zobrazit nápovědu

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