UNLABELLED: Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is a brief, standardized assessment of cognitiveimpairment inamyotrophic lateral sclerosis. OBJECTIVE: We aimed to createa normative dataset for the ECAS Czech version (ECAS-CZ) in order to make the assessment applicable for clinical settings. METHOD: Included were 102 healthy participants (mean age: 54.92 ± 14.55; education: 14.52 ± 2.44; 54:48 females/males) that fulfilled rigorous exclusion criteria and controlled for depressive symptoms. RESULTS: The internal consistency of ECAS-CZ was acceptable (Cronbach's α = .69). We found medium correlations (rho ≈ .5) of age and education with ECAS-CZ Total score but not with gender. Cut-offs with -2 SD's threshold are presented for the differentiation of cognitive impairment. We report percentile values for ECAS-CZ Total including all subscales. CONCLUSION: We provide normative values for ECAS-CZ that are well suited for the detection of cognitive impairment in clinical settings especially for patients with ALS.Supplemental data for this article is available online at https://doi.org/10.1080/13854046.2021.1978553 .
- Keywords
- Cognition, ECAS, behaviour, normative data, screen,
- MeSH
- Amyotrophic Lateral Sclerosis * diagnosis MeSH
- Adult MeSH
- Cognition MeSH
- Cognitive Dysfunction * MeSH
- Cognition Disorders * diagnosis etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Keywords
- Ablation, Anticoagulation, Arrhythmia, Atrial fibrillation, Atrial flutter, Atrial tachycardia, Catheter ablation, Stroke, Surgical ablation,
- MeSH
- Ablation Techniques standards MeSH
- Atrial Fibrillation surgery MeSH
- Cardiology * MeSH
- Catheter Ablation standards MeSH
- Consensus Development Conferences as Topic * MeSH
- Humans MeSH
- Heart Conduction System surgery MeSH
- Societies, Medical * MeSH
- Check Tag
- Humans MeSH
- Publication type
- News MeSH
- Keywords
- Ablation, Anticoagulation, Arrhythmia, Atrial fibrillation, Atrial flutter, Atrial tachycardia, Catheter ablation, Stroke, Surgical ablation,
- MeSH
- Atrial Fibrillation diagnosis physiopathology surgery MeSH
- Catheter Ablation adverse effects standards MeSH
- Consensus MeSH
- Cryosurgery adverse effects standards MeSH
- Humans MeSH
- Risk Factors MeSH
- Cardiac Catheterization adverse effects standards MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Practice Guideline MeSH
- Keywords
- Ablation, Anticoagulation, Arrhythmia, Atrial fibrillation, Atrial flutter, Atrial tachycardia, Catheter ablation, Stroke, Surgical ablation,
- MeSH
- Atrial Fibrillation diagnosis physiopathology surgery MeSH
- Catheter Ablation adverse effects standards MeSH
- Consensus MeSH
- Cryosurgery adverse effects standards MeSH
- Humans MeSH
- Risk Factors MeSH
- Cardiac Catheterization adverse effects standards MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Practice Guideline MeSH
- Keywords
- AAD, antiarrhythmic drug, AF, atrial fibrillation, AFL, atrial flutter, Ablation, Anticoagulation, Arrhythmia, Atrial fibrillation, Atrial flutter, Atrial tachycardia, CB, cryoballoon, CFAE, complex fractionated atrial electrogram, Catheter ablation, LA, left atrial, LAA, left atrial appendage, LGE, late gadolinium-enhanced, LOE, level of evidence, MRI, magnetic resonance imaging, OAC, oral anticoagulation, RF, radiofrequency, Stroke, Surgical ablation,
- Publication type
- Journal Article MeSH
- Keywords
- Ablation, Anticoagulation, Arrhythmia, Atrial fibrillation, Atrial flutter, Atrial tachycardia, Catheter ablation, Stroke, Surgical ablation,
- MeSH
- Atrial Fibrillation diagnosis physiopathology surgery MeSH
- Cardiac Surgical Procedures standards MeSH
- Catheter Ablation standards MeSH
- Consensus MeSH
- Humans MeSH
- Risk Factors MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Keywords
- Ablation, Anticoagulation, Arrhythmia, Atrial fibrillation, Atrial flutter, Atrial tachycardia, Catheter ablation, Stroke, Surgical ablation,
- Publication type
- Journal Article MeSH
PURPOSE: The 2018 International Federation of Gynecology and Obstetrics (FIGO) update on cervical cancer staging eliminated horizontal tumor extent (HZTE) as a staging parameter in stage IA (microscopic) disease. We aimed to determine whether HZTE correlates with outcomes in early stage ECAs and FIGO should reinstate HZTE as a staging parameter in futures updates. METHODS: We retrospectively analyzed 416 FIGO 2009 stage I ECAs from 17 institutions and re-assigned stage using FIGO 2018. Correlation between HZTE, overall (OS) and recurrence free survival (RFS) was performed using univariable and multivariable analyses. RESULTS: Re-staging 416 cases resulted in 126 (30.3%) IA and 290 (69.7%) IB cases; 85 (67.5%) IA tumors had HZTE ≤ 7 mm, while 41 (32.5%) were > 7 mm; 32 (11%) IB tumors had HZTE ≤ 7 mm, while 258 (89%) were > 7 mm (p = 0.0001). Four (3.2%) IA (1 IA1, 3 IA2) patients developed recurrence (3 ≤ 7 mm, 1 > 7 mm) compared to 41 (14.1%) IB patients (p = 0.002). Fourteen IB and no IA patients died of disease (8 IB1, 1 ≤ 7 mm). Cox univariate analysis demonstrated that only RFS is significantly influenced by HZTE (p = 0.01), while OS and RFS were not influenced by HZTE on multivariate analysis. CONCLUSION: HZTE has limited prognostic value in early stage ECAs and is only associated with RFS on univariate but not multivariate analysis. HZTE does not improve prognostication of patients with stage I ECAs as per 2018 FIGO staging. Consequently, the rationale to remove this variable from FIGO staging is justified for ECAs.
- Keywords
- Endocervical adenocarcinoma, FIGO, Horizontal tumor extent, Management, Prognostic significance, Stage,
- MeSH
- Adenocarcinoma pathology surgery MeSH
- Adult MeSH
- Hysterectomy methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Survival Rate MeSH
- Uterine Cervical Neoplasms pathology surgery MeSH
- Follow-Up Studies MeSH
- Prognosis MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
In the period from 2000 to 2005, with support of several grants, a unique multi-media center for teaching endoscopic techniques was established at the Department of Anatomy, 3rd Faculty of Medicine, Charles University in Prague. This conditions have been provided for the repeated use of cadavers preserved by a special embalming method of Professor Thiel of the Institute for Anatomy, University of Graz, for simulation of surgical procedures. One room of the Department has been converted into a small operating theatre and an audio-visual network with wireless Internet connection covers the whole dissection unit of the Department. A graphic studio for production of teaching materials has also been set up. The course in dissection for the first- and second-year medical students also includes demo arthroscopy. In addition to the courses for students, postgraduate courses for young surgeons are organized. These provide an opportunity to learn about techniques and instruments employed in a broad range of arthroscopic procedures, using appropriate cadaver materials.
- MeSH
- Arthroscopy * MeSH
- Audiovisual Aids MeSH
- Humans MeSH
- Cadaver MeSH
- Education, Medical, Undergraduate * MeSH
- Check Tag
- Humans MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Geographicals
- Czech Republic MeSH
The study aimed to investigate the influence of obesity on cellular features of equine endometrial progenitor cells (Eca EPCs), including viability, proliferation capacity, mitochondrial metabolism, and oxidative homeostasis. Eca EPCs derived from non-obese (non-OB) and obese (OB) mares were characterized by cellular phenotype and multipotency. Obesity-induced changes in the activity of Eca EPCs include the decline of their proliferative activity, clonogenic potential, mitochondrial metabolism, and enhanced oxidative stress. Eca EPCs isolated from obese mares were characterized by an increased occurrence of early apoptosis, loss of mitochondrial dynamics, and senescence-associated phenotype. Attenuated metabolism of Eca EPCs OB was related to increased expression of pro-apoptotic markers (CASP9, BAX, P53, P21), enhanced expression of OPN, PI3K, and AKT, simultaneously with decreased signaling stabilizing cellular homeostasis (including mitofusin, SIRT1, FOXP3). Obesity alters functional features and the self-renewal potential of endometrial progenitor cells. The impaired cytophysiology of progenitor cells from obese endometrium predicts lower regenerative capacity if used as autologous transplants.
- Keywords
- cellular metabolism, endometrial progenitor cells, obesity, self-renewal potential,
- MeSH
- Endometrium metabolism MeSH
- Endothelial Progenitor Cells * metabolism MeSH
- Phenotype MeSH
- Stem Cells metabolism MeSH
- Horses MeSH
- Obesity metabolism MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
