This study examined the effects of a nine-week intervention of four different high-intensity training modalities [high-intensity functional training (HIFT), high-intensity interval training (HIIT), high-intensity power training (HIPT), and high-intensity endurance training (HIET)] on the resting concentration of brain-derived neurotropic factor (BDNF). In addition, we evaluated the BDNF responses to Graded Exercise Test (GXT) and Wingate Anaerobic Test (WAnT) in men. Thirty-five healthy individuals with body mass index 25.55 ± 2.35 kg/m2 voluntarily participated in this study and were randomly assigned into four training groups. During nine-weeks they completed three exercise sessions per week for one-hour. BDNF was analyzed before and after a GXT and WAnT in two stages: (stage 0-before training and stage 9-after nine weeks of training). At stage 0, an increase in BDNF concentration was observed in HIFT (33%; p < 0.05), HIPT (36%; p < 0.05) and HIIT (38%; p < 0.05) after GXT. Even though HIET showed an increase in BDNF (10%) this was not statistically significant (p > 0.05). At stage 9, higher BDNF levels after GXT were seen only for the HIFT (30%; p < 0.05) and HIIT (18%; p < 0.05) groups. Reduction in BDNF levels were noted after the WAnT in stage 0 for HIFT (- 47%; p < 0.01), HIPT (- 49%; p < 0.001), HIET (- 18%; p < 0.05)], with no changes in the HIIT group (- 2%). At stage 9, BDNF was also reduced after WAnT, although these changes were lower compared to stage 0. The reduced level of BDNF was noted in the HIFT (- 28%; p < 0.05), and HIPT (- 19%;p < 0.05) groups. Additionally, all groups saw an improvement in VO2max (8%; p < 0.001), while BDNF was also correlated with lactate and minute ventilation and selected WAnT parameters. Our research has shown that resting values of BDNF after nine weeks of different forms of high-intensity training (HIT) have not changed or were reduced. Resting BDNF measured at 3th (before GXT at stage 9) and 6th day after long lasting HITs (before WAnT at stage 9) did not differed (before GXT), but in comparison to the resting value before WAnT at the baseline state, was lower in three groups. It appears that BDNF levels after one bout of exercise is depended on duration time, intensity and type of test/exercise.

• MeSH
• cvičení fyziologie   MeSH
• dospělí MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• mozkový neurotrofický faktor metabolismus   MeSH
• odpočinek fyziologie   MeSH
• vysoce intenzivní intervalový trénink metody   MeSH
• zátěžový test metody   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• BDNF protein, human MeSH Prohlížeč
• mozkový neurotrofický faktor MeSH

Lifestyle intervention encompassing nutrition and physical activity are effective strategies to prevent progressive lipid deposition in the liver. This study aimed to explore the effect of dietary change, and/or high-intensity interval training (HIIT) on hepatic lipid accumulation in high fat diet (HFD)-induced obese rats. We divided lean rats into lean control (LC) or HIIT groups (LH), and obese rats into obese normal chow diet (ND) control (ONC) or HIIT groups (ONH) and obese HFD control (OHC) or HIIT groups (OHH). We found that dietary or HIIT intervention significantly decreased body weight and the risk of dyslipidemia, prevented hepatic lipid accumulation. HIIT significantly improved mitochondrial fatty acid oxidation through upregulating mitochondrial enzyme activities, mitochondrial function and AMPK/PPARalpha/CPT1alpha pathway, as well as inhibiting hepatic de novo lipogenesis in obese HFD rats. These findings indicate that dietary alone or HIIT intervention powerfully improve intrahepatic storage of fat in diet induced obese rats. Keywords: Obesity, Exercise, Diet, Mitochondrial function, Lipid deposition.

• MeSH
• dieta s vysokým obsahem tuků * škodlivé účinky   MeSH
• játra * metabolismus   MeSH
• kondiční příprava zvířat fyziologie   MeSH
• krysa rodu Rattus MeSH
• metabolismus lipidů * MeSH
• obezita * metabolismus   terapie   MeSH
• potkani Sprague-Dawley * MeSH
• vysoce intenzivní intervalový trénink * MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

High-intensity interval training (HIIT) is frequently utilized as a method to reduce body mass. Its intensity of work results in a number of beneficial adaptive changes in a relatively short period of time. Irisin is a myokine and adipokine secreted to the blood during exercise and it takes part in the regulation of energy metabolism. It is a vital issue from the prophylaxis point of view as well as treatment through exercise of different diseases (e.g., obesity, type-2 diabetes). The aim of this study was to evaluate changes in irisin concentration, body composition, and aerobic and anaerobic performance in men after HIIT. Eight weeks of HIIT following the Tabata protocol was applied in the training group (HT) (n = 15), while a sedentary group (SED) (n = 10) did not participate in fitness activities within the same time period. Changes of irisin, body composition, and aerobic and anaerobic performance were evaluated after graded exercise test (GXT) and Wingate anaerobic test (WAnT) before and after eight weeks of training. Training resulted in an increased of blood irisin concentration (by 29.7%) p < 0.05), VO2max increase (PRE: 44.86 ± 5.74 mL·kg-1·min-1; POST: 50.16 ± 5.80 mL kg-1·min-1; p < 0.05), reduction in percent body fat (PRE: 14.44 ± 3.33%; POST: 13.61 ± 3.16%; p < 0.05), and increase of WAnT parameters (p < 0.05) in the HT group. No changes were observed in the SED group. HIIT resulted in beneficial effects in the increase in blood irisin concentration, physical performance, and reduced fat content. The HIIT may indicate an acceleration of base metabolism. This effect can be utilized in the prevention or treatment of obesity.

• Klíčová slova
• HIIT, basal metabolism, fat reduction, fitness, health, irisin, lean body mass, power output,
• MeSH
• cvičení MeSH
• fibronektiny krev   MeSH
• lidé MeSH
• obezita prevence a kontrola   MeSH
• sedavý životní styl MeSH
• složení těla * MeSH
• tělesná a funkční výkonnost * MeSH
• vysoce intenzivní intervalový trénink * MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• fibronektiny MeSH
• FNDC5 protein, human MeSH Prohlížeč

Structural neuroplasticity such as neurite extension and dendritic spine dynamics is enhanced by brain-derived neurotrophic factor (BDNF) and impaired by types of inhibitory molecules that induce growth cone collapse and actin depolymerization, for example, myelin-associated inhibitors, chondroitin sulfate proteoglycans, and negative guidance molecules. These inhibitory molecules can activate RhoA/rho-associated coiled-coil containing protein kinase (ROCK) signaling (known to restrict structural plasticity). Intermittent hypoxia (IH) and high-intensity interval training (HIIT) are known to upregulate BDNF that is associated with improvements in learning and memory and greater functional recovery following neural insults. We investigated whether the RhoA/ROCK signaling pathway is also modulated by IH and HIIT in the hippocampus, cortex, and lumbar spinal cord of male Wistar rats. The gene expression of 25 RhoA/ROCK signaling pathway components was determined following IH, HIIT, or IH combined with HIIT (30 min/day, 5 days/wk, 6 wk). IH included 10 3-min bouts that alternated between hypoxia (15% O2) and normoxia. HIIT included 10 3-min bouts alternating between treadmill speeds of 50 cm·s-1 and 15 cm·s-1. In the hippocampus, IH and HIIT significantly downregulated Acan and NgR2 mRNA that are involved in the inhibition of neuroplasticity. However, IH and IH + HIIT significantly upregulated Lingo-1 and NgR3 in the cortex. This is the first time IH and HIIT have been linked to the modulation of plasticity-inhibiting pathways. These results provide a fundamental step toward elucidating the interplay between the neurotrophic and inhibitory mechanisms involved in experience-driven neural plasticity that will aid in optimizing physiological interventions for the treatment of cognitive decline or neurorehabilitation.NEW & NOTEWORTHY Intermittent hypoxia (IH) and high-intensity interval training (HIIT) enhance neuroplasticity and upregulate neurotrophic factors in the central nervous system (CNS). We provide evidence that IH and IH + HIIT also have the capacity to regulate genes involved in the RhoA/ROCK signaling pathway that is known to restrict structural plasticity in the CNS. This provides a new mechanistic insight into how these interventions may enhance hippocampal-related plasticity and facilitate learning, memory, and neuroregeneration.

• Klíčová slova
• exercise, inhibitory molecules, intermittent hypoxia, neuroplasticity, treadmill training,
• MeSH
• hipokampus * metabolismus   MeSH
• hypoxie metabolismus   patofyziologie   MeSH
• kinázy asociované s Rho * metabolismus   genetika   MeSH
• krysa rodu Rattus MeSH
• mícha metabolismus   fyziologie   MeSH
• mozková kůra metabolismus   fyziologie   MeSH
• neuroplasticita fyziologie   MeSH
• potkani Wistar * MeSH
• Rho proteiny vázající GTP MeSH
• rhoA protein vázající GTP metabolismus   MeSH
• signální transdukce * fyziologie   MeSH
• vysoce intenzivní intervalový trénink * MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• kinázy asociované s Rho * MeSH
• Rho proteiny vázající GTP MeSH
• rhoA protein vázající GTP MeSH
• RhoA protein, rat MeSH Prohlížeč

We aimed to determine the persisting effects of various exercise modalities and intensities on functional capacity after periods of training cessation in older adults. A comprehensive search was conducted across the Cochrane Library, PubMed/MEDLINE, Scopus, and Web of Science Core Collection up to March 2024 for randomized controlled trials examining residual effects of physical exercise on functional capacity in older adults ≥ 60 years. The analysis encompassed 15 studies and 21 intervention arms, involving 787 participants. The exercise and training cessation periods ranged from 8 to 43 weeks and 4 to 36 weeks, respectively. Meta-analyses were performed using change scores from before the physical exercise to after the training cessation. The effect sizes (ES) were calculated as the standardized mean differences between the intervention and control groups' change scores. Subgroup analyses and meta-regressions explored the influence of participant characteristics, the magnitude of the effect produced by the initial training program, various exercise modalities (resistance and multicomponent training) and intensities (high and low), and subdomains of functional capacity (agility, balance, standing ability, walking ability, and stair walking). The findings revealed that exercise interventions had a significant effect on preserving functional capacity after training cessation (ES = 0.87; p < 0.01). This protective effect was consistent across various exercise modalities and intensities (ES ≥ 0.67; p ≤ 0.04). The benefits obtained during the training program were positively associated with the residual effects observed after training cessation (β = 0.73; p < 0.01), while age negatively influenced the persisting adaptations (β = -0.07; p < 0.01). Current evidence suggests that exercise-based interventions, irrespective of modality and intensity, are highly effective in preventing functional declines after training cessation among older adults.

• Klíčová slova
• deconditioning, functional impairments, long‐term effects, physical inactivity,
• MeSH
• cvičení * fyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• odporový trénink metody   MeSH
• posturální rovnováha fyziologie   MeSH
• randomizované kontrolované studie jako téma MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• metaanalýza MeSH
• přehledy MeSH
• systematický přehled MeSH

BACKGROUND: Examination of pelvic floor muscle function is very important before starting exercises in patients with urine leakage and other pelvic floor dysfunctions. Perineometer and palpation examination is currently being used. A new trend in physiotherapy is the ultrasound examination of pelvic floor muscles. The examination can be performed by abdominal approach or perineal approach. We evaluate 2D and 3/4D images of pelvic floor muscles. METHODS: The International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form (ICIQ-UI SF). OAB-q - overactive bladder questionnaire - short form. The Urinary Incontinence Quality of Life scale (I-QoL) - self-assessment scale for assessing the quality of life of patients with urinary incontinence. Adjusted Oxford scale to assess pelvic floor muscle strength. PERFECT scheme by Laycock and Jerwood. Pelvic floor examination by perineometer (Peritron-Ontario, L4V, Canada). Pelvic floor examination by 2D and 3/4D ultrasound examination (Volunson-i BT 11 Console, VCI volume contrast imaging software, (GE Healthcare Austria GmbH & Co OG, Zipf, Austria, RAB4-8-RS 3D/4D 4-8 MHz probe). High intensity exercise of pelvic floor muscles with stabilization elements. CONCLUSION: The effect of pelvic floor muscle training was objectively proved by the above mentioned objectivization methods with subjective improvement of quality of life. There was also a significant effect of education in USG exercise.

• Klíčová slova
• high intensity, objectivization, pelvic floor exercise, stress urinary incontinence,
• MeSH
• inkontinence moči diagnóza   psychologie   rehabilitace   MeSH
• kvalita života MeSH
• lidé MeSH
• pánevní dno diagnostické zobrazování   fyziologie   MeSH
• stresová inkontinence moči diagnóza   psychologie   rehabilitace   MeSH
• terapie cvičením metody   MeSH
• ultrasonografie MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

This interventional study examined the effect of a four-week vegan diet (VegD) during a four-week high-intensity functional training (HIFT) on performance, training results and blood biochemical indices in female (n = 12) and male (n = 8) moderate-trained CrossFit participants. The whole study group performed the maximum number of repetitions with a load of 70% one repetition-maximum (1RM) and a modified Fight Gone Bad (FGBMod) test before and after a dietary intervention (the group was divided to follow a VegD or a traditional mixed diet (MixD)) in a randomised and parallel design. Pre-exercise resting blood samples were also analysed. There was a significant improvement in the number of repetitions performed at a load corresponding to 70% of 1RM in the classic squat in the MixD group (p < 0.001), and in the classic deadlift in the VegD group (p = 0.014). Furthermore, there was a significant improvement in the results of the FGBMod performance test after a MixD. Moreover, an improvement in some exercises in the modified FGBMod test (Wall Ball after the VegD and the MixD, and rowing after the MixD) was also observed. However, differences between the MixD and the VegD groups were not clinically relevant. In conclusion, the short-term study conducted here indicated that a VegD in HIFT training positively affects strength endurance in the classic deadlift but is unlikely to be more beneficial in improving performance than a MixD.

• Klíčová slova
• exercise performance, high-intensity functional training, nutritional support, sports nutrition, strength, vegetarianism,
• MeSH
• cvičení MeSH
• dieta veganská * MeSH
• kosterní svaly MeSH
• lidé MeSH
• odporový trénink * MeSH
• svalová síla MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH

In the past, older adults were traditionally deemed too weak or fragile to participate in high-intensity exercise, but more recent research indicates that not only is high-intensity exercise not dangerous in this population, but it may in fact be a preferable form of exercise over other, less-intense alternatives. However, many seniors still do not participate in high-intensity exercise despite the mounting evidence that it can improve a number of physiological functions and ultimately increase quality of life. As health, sport, and medical professionals, we must continuously ask ourselves how we can apply our lab-based findings in real-life scenarios, and in the case of older adults, we must find a way to circumvent some of their most common reasons for not exercising, which can include a lack of time, a lack of know-how, a lack of motivation, a fear that high-intensity exercise is unsafe, and a perception that high-intensity exercise is too difficult. Therefore, introducing quick, simple, safe, and perceptually easy exercises may result in immediate health and functional benefits and may serve as a gateway exercise to usher older adults into the realm of high-intensity training. Specifically, assisted jumping could serve this purpose. In this article, the ideas behind the theory and practice of assisted jumping are set forth, providing an evidence-based hypothesis from which future researchers can build on to implement high-speed, high-power, high-intensity exercise in older populations in both research and practical settings.

• MeSH
• bezpečnost pacientů MeSH
• biomechanika MeSH
• geriatrie MeSH
• kondiční příprava metody   MeSH
• kvalita života MeSH
• lidé MeSH
• senioři MeSH
• sportovci MeSH
• sporty MeSH
• teoretické modely MeSH
• terapie cvičením metody   MeSH
• zdravotní služby pro seniory MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: The purpose was to examine the energy cost and cardiorespiratory demands of nunchaku exercise, one of the martial arts performed with an instrument. METHODS: Nine male martial art practitioners (age 26.4 (+/-SD) 3.4 years, VO2max 54.1+/-9.0 ml x kg(-1)x min(-1)) completed three nunchaku exercise trials, lasting 20 sec, 1 min and 5 min. Cardiorespiratory response was followed by the Cosmed K4 portable respiratory analysis system. MEASURES: Oxygen consumption (VO2) was determined during pre-exercise rest, the exercise period and the recovery phase (10-15 min), and energy release from lactate (La) production was calculated assuming that an increase of 1 mmol x l(-1) corresponds to aVO2 of 3 ml O2 (di Prampero 1981). RESULTS: The overall energy cost of nunchaku exercise attained 76+/-16 kJ (229+/-48 kJ x min(-1)), 98+/-23 kJ and 271+/-72 kJ (54+/-14 kJ x min(-1)) for the 20 sec, 1 min and 5 min nunchaku exercise, respectively. From the point of view of the energy sources (alactic, lactic and oxidative), 20-sec performance was essentially "anaerobic alactic" (69:15:16%), 1 min exercise "alactic-oxidative" (49:16:35%) and 5-min performance an "oxidative" exercise workload (17% alactic: 6% lactic: 77% oxidative, respectively). The intensity of the exercise, on the average, corresponded to 43, 49 and 56% of VO2max and 69, 72 and 76% of HRmax, for the 20 sec, 1 min and 5 min exercises, respectively. CONCLUSIONS: Nunchaku exercise elicits high alactic and oxidative energy sources, but its demand for anaerobic glycolytic pathway seem to be relatively low, regardless the duration of the exercise. The energy cost (EC) for 20-sec to 5-min lasting exercise may be described by power function EC=10.84.t(-0.522) (n=24, r2=0.95), where EC is in kJ x min(-1) x kg(-1) and t in seconds.

• MeSH
• anaerobní práh fyziologie   MeSH
• analýza rozptylu MeSH
• bojové sporty fyziologie   MeSH
• časové faktory MeSH
• dospělí MeSH
• energetický metabolismus * fyziologie   MeSH
• glykolýza fyziologie   MeSH
• kyslík krev   MeSH
• laktáty krev   MeSH
• lidé MeSH
• oxid uhličitý krev   MeSH
• plíce fyziologie   MeSH
• plicní ventilace fyziologie   MeSH
• regresní analýza MeSH
• sportovní vybavení MeSH
• spotřeba kyslíku fyziologie   MeSH
• srdce fyziologie   MeSH
• srdeční frekvence fyziologie   MeSH
• výměna plynů v plicích fyziologie   MeSH
• zátěžový test MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• kyslík MeSH
• laktáty MeSH
• oxid uhličitý MeSH

The randomized trials showed that the addition of training resistance program to androgen-deprivation therapy (ADT) had many beneficial effects for prostate cancer (PC) patients (significant protective effect on the volume of muscle mass) and the studies have revealed a panel of miRNAs, which are deregulate in PC and may serve as promising biomarkers of PC risk. The primary aim of our present study was to investigate the effect of exercise training to changes in body composition (muscle strength) and the secondary endpoint was to investigate the impact of an exercise training program on plasma levels of selected myogenic microRNAs (miRNAs) (miRNA-1, miRNA-29b, and miRNA-133) in PC patients undergoing the ADT. Effect of ADT and exercise intervention showed significant increase (experimental group vs. control group) the changes in body composition, free testosterone levels, IL-6 and plasma levels of myogenic miRNAs and significant reduced insulin serum levels. In conclusion, resistance training with ADT in the treatment of PC significantly changed the physical and metabolic function and the plasma levels of specific myogenic miRNAs. Our data support with the other publicized results.

• MeSH
• antagonisté androgenů terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mikro RNA krev   MeSH
• nádory prostaty krev   terapie   MeSH
• odporový trénink * MeSH
• prospektivní studie MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• antagonisté androgenů MeSH
• mikro RNA MeSH