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Effect of Helicteres isora bark extracts on heart antioxidant status and lipid peroxidation in streptozotocin diabetic rats
Ganesan Kumar, Gani Sharmila Banu, Arunachalam Ganesan Murugesan
Language English Country Czech Republic
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- MeSH
- Diabetes Mellitus, Experimental complications metabolism MeSH
- Catalase pharmacokinetics metabolism MeSH
- Lipid Peroxidation genetics radiation effects MeSH
- Rats, Wistar MeSH
- Reactive Oxygen Species metabolism adverse effects MeSH
- Plant Extracts pharmacokinetics metabolism MeSH
- Malvaceae metabolism drug effects MeSH
- Streptozocin metabolism adverse effects MeSH
- Superoxide Dismutase pharmacokinetics metabolism MeSH
- Tolbutamide pharmacokinetics metabolism MeSH
The present study investigated the effect of the aqueous extract of Helicteres isora L (Sterculiaceae) bark on oxidative stress in the heart of rats during diabetes. The aqueous extract of Helicteres isora bark (100 mg, 200 mg/kg body weight (b.w.)) was screened for its antioxidant effect in streptozotocin (STZ) induced diabetic rats. An appreciable decrease in peroxidation products, thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD), and hydroperoxides (HP) was observed in the heart tissues of Helicteres isora (HI) treated diabetic rats. The decreased activities of key antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-tranferase (GST) and glutathione (GSH) in diabetic rats were brought back to near normal range upon HI treatment. Tolbutamide was used as the standard reference drug. These results suggest that HI possesses promising antioxidative activity in STZ diabetic rats.
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Lit.: 43
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- $a Effect of Helicteres isora bark extracts on heart antioxidant status and lipid peroxidation in streptozotocin diabetic rats / $c Ganesan Kumar, Gani Sharmila Banu, Arunachalam Ganesan Murugesan
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- $a Address: Ganesan Kumar, Head, Faculty of Biochemistry, Selvamm Arts and Science College, Namakkal (DT)-637 003, Tamilnadu, India; pgsvedhakumar@yahoo.com
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- $a Lit.: 43
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- $a The present study investigated the effect of the aqueous extract of Helicteres isora L (Sterculiaceae) bark on oxidative stress in the heart of rats during diabetes. The aqueous extract of Helicteres isora bark (100 mg, 200 mg/kg body weight (b.w.)) was screened for its antioxidant effect in streptozotocin (STZ) induced diabetic rats. An appreciable decrease in peroxidation products, thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD), and hydroperoxides (HP) was observed in the heart tissues of Helicteres isora (HI) treated diabetic rats. The decreased activities of key antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-tranferase (GST) and glutathione (GSH) in diabetic rats were brought back to near normal range upon HI treatment. Tolbutamide was used as the standard reference drug. These results suggest that HI possesses promising antioxidative activity in STZ diabetic rats.
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