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5-lipoxygenase, leukotrienes biosynthesis and potential antileukotrienic agents

Jampilek J, Dolezal M, Opletalova V, Hartl J

. 2006 ; 13 (2) : 117-129.

Language English Country Netherlands

Document type Review

E-resources Online

NLK ProQuest Central from 2000-01-01 to 2008-12-31
Health & Medicine (ProQuest) from 2000-01-01 to 2008-12-31

Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.

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