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5-lipoxygenase, leukotrienes biosynthesis and potential antileukotrienic agents
Jampilek J, Dolezal M, Opletalova V, Hartl J
Language English Country Netherlands
Document type Review
NLK
ProQuest Central
from 2000-01-01 to 2008-12-31
Health & Medicine (ProQuest)
from 2000-01-01 to 2008-12-31
- MeSH
- Leukotriene Antagonists pharmacology MeSH
- Anti-Asthmatic Agents pharmacology MeSH
- Anti-Inflammatory Agents pharmacology MeSH
- Arachidonate 5-Lipoxygenase metabolism MeSH
- Financing, Organized MeSH
- Lipoxygenase Inhibitors MeSH
- Arachidonic Acids metabolism MeSH
- Leukotrienes biosynthesis MeSH
- Humans MeSH
- Substrate Specificity MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Review MeSH
Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
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- $a Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
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