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5-lipoxygenase, leukotrienes biosynthesis and potential antileukotrienic agents
Jampilek J, Dolezal M, Opletalova V, Hartl J
Jazyk angličtina Země Nizozemsko
Typ dokumentu přehledy
NLK
ProQuest Central
od 2000-01-01 do 2008-12-31
Health & Medicine (ProQuest)
od 2000-01-01 do 2008-12-31
- MeSH
- antagonisté leukotrienů farmakologie MeSH
- antiastmatika farmakologie MeSH
- antiflogistika farmakologie MeSH
- arachidonát-5-lipoxygenasa metabolismus MeSH
- financování organizované MeSH
- inhibitory lipoxygenas MeSH
- kyseliny arachidonové metabolismus MeSH
- leukotrieny biosyntéza MeSH
- lidé MeSH
- substrátová specifita MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
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- $a Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
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