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Chiral separation of tamsulosin by capillary electrophoresis
Maier V, Horáková J, Petr J, Tesarová E, Coufal P, Sevcík J.
Language English Country Great Britain
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Acetonitriles analysis MeSH
- Adrenergic alpha-Antagonists analysis chemistry MeSH
- beta-Cyclodextrins analysis chemistry MeSH
- Time Factors MeSH
- Models, Chemical MeSH
- Electrophoresis, Capillary methods instrumentation MeSH
- Electrophoresis MeSH
- Electrolytes MeSH
- Financing, Organized MeSH
- Furans analysis chemistry MeSH
- Calibration MeSH
- Acetic Acid chemistry MeSH
- Osmosis MeSH
- Reproducibility of Results MeSH
- Sulfur chemistry MeSH
- Stereoisomerism MeSH
- Sulfonamides analysis chemistry MeSH
- Chromatography, High Pressure Liquid MeSH
- Dose-Response Relationship, Drug MeSH
Enantiomers of (+/-) 5-[2 (R,S)-{[2-(o-ethoxyphenoxy) ethyl] amino} propyl]-2-methoxy-benzenesulfonamide (tamsulosin, drug frequently used in the treatment of prostate diseases) were separated by capillary electrophoresis (CE). An acidic background electrolyte (BGE) with sulfated-beta-cyclodextrin (S-beta-CD) was used to create a chiral separation environment. Baseline separation of the isomers was achieved during 5 min using cathodic electro-osmotic flow (EOF) (countercurrent mode). The quantification limits were 5.3 x 10(-6) moll(-1) for R-isomer and 5.7 x 10(-6) moll(-1) for S-isomer. The R.S.D. values of peak area were 0.54% for R-isomer and 0.75% for S-isomer. The results achieved enable determination of 0.5% of optical impurity.
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- $a Maier, Vítězslav, $d 1979- $7 mzk2006356017
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- $a Chiral separation of tamsulosin by capillary electrophoresis / $c Maier V, Horáková J, Petr J, Tesarová E, Coufal P, Sevcík J.
- 314 __
- $a Department of Analytical Chemistry, Palacký University, Trída Svobody 8, CZ-77146 Olomouc, Czech Republic. maierv@email.cz
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- $a Enantiomers of (+/-) 5-[2 (R,S)-{[2-(o-ethoxyphenoxy) ethyl] amino} propyl]-2-methoxy-benzenesulfonamide (tamsulosin, drug frequently used in the treatment of prostate diseases) were separated by capillary electrophoresis (CE). An acidic background electrolyte (BGE) with sulfated-beta-cyclodextrin (S-beta-CD) was used to create a chiral separation environment. Baseline separation of the isomers was achieved during 5 min using cathodic electro-osmotic flow (EOF) (countercurrent mode). The quantification limits were 5.3 x 10(-6) moll(-1) for R-isomer and 5.7 x 10(-6) moll(-1) for S-isomer. The R.S.D. values of peak area were 0.54% for R-isomer and 0.75% for S-isomer. The results achieved enable determination of 0.5% of optical impurity.
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