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Transkarbams with terminal branching as transdermal permeation enhancers
J. Klimentová, P. Kosák, K. Vávrová, T. Holas, J. Novotný, A. Hrabálek
Jazyk angličtina Země Velká Británie
NLK
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
- MeSH
- aplikace kožní MeSH
- financování organizované MeSH
- karbamáty farmakokinetika chemie MeSH
- kožní absorpce účinky léků MeSH
- kůže MeSH
- permeabilita MeSH
- prasata MeSH
- theofylin aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.
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- $a Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.
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